Clinical trials: Heart; Disease, Functional
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Atrial Fibrillation
Changes of Left Atrial Function and Quality of Life After Transcatheter Closure of Left Atrial Appendage in Patients With Atrial Fibrillation
A total of 105 (AF) patients with atrial fibrillation are scheduled to undergo surgery and will be divided into three groups. Left atrial appendage occlusion ((LAAC)), radiofrequency ablation guided by three-dimensional mapping…
- Trial name
- NCT04376606
- Testing
- Left atrial appendage closure, Radiofrequency ablation, LAAC combined with radiofrequency ablation group
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Ruiqin xie
Coronary Artery Bypass Grafting, Coronary Artery Disease
Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Background: Coronary artery bypass grafting (CABG) due to coronary artery disease (CAD) is one of the main surgical procedures performed in the area of cardiology.
- Conditions
- Coronary Artery Bypass Grafting, Coronary Artery Disease, Cardiac Rehabilitation
- Trial name
- CEFREET (NCT03096158)
- Testing
- Ventilatory Muscle Training (TREMVEN), Aerobic Training (AERO), Isometric Handgrip Training (ISO)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Cardiovascular Diseases, Heart Diseases
Sociodemographic Regulation of Cardiovascular Function and Structure
To establish the aspects of ethnicity that are associated with the differential expression of cardiovascular disease processes in African Americans and Caucasian Americans twin children.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005476
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Aerobic Exercise
Effects of Rehabilitation in Patients With Stable Chronic Heart Failure
Heart failure (HF) is a major public health problem. This is the first cause of hospitalization and mortality of about 65 years old. This syndrome is characterized by a poor prognosis and a high cost of care.
- Conditions
- Heart Failure, Aerobic Exercise, Quality of Life, Respiratory Muscle Training
- Trial name
- NCT03538249
- Testing
- Aerobic training, Inspiratory muscle training, Resistance Training
- Volunteers
- 60 people
- Sponsor
- Lebanese University
Hypothyroidism, CHD
Hypothyroidism With Congenital Heart Disease (CHD)
Congenital hypothyroidism is one of the most preventable causes of neurocognitive impairment because early treatment is possible in neonates. The thyroid hormone is important for normal growth and development in infancy.
- Trial name
- NCT03496363
- Testing
- TSH , T4
- Volunteers
- 50 people
- Sponsor
- Assiut University
Coronary Artery Disease
Effect of Cranberry Juice on Endothelial Function
A pilot study of 15 subjects will be completed to determine whether acute consumption of cranberry juice has an effect on endothelial function.
- Trial name
- NCT00553904
- Testing
- Cranberry juice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Pregnancy, Obesity
The Impact of Obesity on Cardiac Function in Pregnancy
The purpose of this study is to determine the impact of obesity in pregnancy on maternal cardiac function. For this, morbidly obese term pregnant women (study group) and term pregnant women of normal weight are assessed by…
- Trial name
- CFOP (NCT02677558)
- Testing
- Transthoracic Echocardiography
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Cape Town
Cardiovascular Disease, Renal Insufficiency, Acute
Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.
- Conditions
- Cardiovascular Disease, Renal Insufficiency, Acute, Cardiopulmonary Bypass
- Trial name
- NCT00190034
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Endothelial Dysfunction, Vascular Stiffness
Sodium Lowering Vascular Effects Trial
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension.
- Conditions
- Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction
- Trial name
- SOLVE (NCT05388032)
- Testing
- Sodium Reduction Intervention
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Tulane University
Bradycardia, Syncope, Vasovagal
Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the…
- Conditions
- Bradycardia, Syncope, Vasovagal, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- CRYO-CNA vs RF (NCT07671898)
- Testing
- Focal Cryoablation, Radiofrequency Catheter Ablation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Disease
Magnetic Resonance Imaging of the Blood Vessels of the Heart
This study is directed at evaluating patients with "myocardial ischemia" or poor blood supply to the heart muscle due to coronary artery disease.
- Trial name
- NCT00001638
- Where
- 2 sites in United States
- Volunteers
- 2,916 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
Left Atrial Mechanical Function Improvement After Atrial Fibrillation Catheter Ablation
The objective of the study was to estimate the efficacy of telmisartan and amlodipine combination on the restoration of left atrial mechanical function after atrial fibrillation catheter ablation.
- Trial name
- NCT02734355
- Testing
- Telmisartan 80 mg and amlodipine 5 mg
- Volunteers
- 64 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Type 1 Diabetes, T1D Heart Failure
Precision T1D Platform - New Therapies for Cardio-Renal Complications
Breakthrough T1D has awarded support for a joint University of Michigan-Oregon Health \& Science University Center of Excellence (CoE) to address cardio-renal complications in T1D.
- Conditions
- Type 1 Diabetes, T1D Heart Failure, Cardio-renal Vascular Function and Failure, Diabetic Chronic Kidney Disease
- Trial name
- NCT07594145
- Testing
- Finerenone, Sotagliflozin
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Oregon Health and Science University
Primary Aldosteronism, Adrenal Tumor
Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors
The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.
- Conditions
- Primary Aldosteronism, Adrenal Tumor, Cushing s Syndrome, Pheochromocytoma/Paraganglioma (PPGL)
- Trial name
- NCT07182175
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Aging, Heart Failure
The COmPLETE Study
The project is designed as a large scale, cross-sectional study. This research seeks to identify physical fitness and cardiovascular parameters that best resemble underlying cardiovascular risk with age.
- Trial name
- COmPLETE (NCT03986892)
- Testing
- Physical Activity
- Where
- Switzerland
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- Arno Schmidt-Trucksäss
Stroke
Tai Chi Training in Stroke Survivors
People with stroke suffer from different impairments, including the ability to dual-tasking, increased arterial stiffness, and dysfunction of the autonomic nervous system.
- Trial name
- NCT03252236
- Testing
- Tai Chi, Conventional exercise
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University
Fibromyalgia Syndrome
Unilateral and Bilateral taVNS in Fibromyalgia
This randomized controlled trial aimed to compare the effects of unilateral (left-sided) and bilateral transcutaneous auricular vagus nerve stimulation (taVNS) combined with a home exercise program on clinical outcomes, autonomic…
- Trial name
- taVNS-FMS (NCT07577102)
- Testing
- taVNS, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Gelisim University
Myocardial Infarct, Hyperglycemia
Impact of Tight Glycaemic Control in Acute Myocardial Infarction
To determine whether tight glycaemic control with insulin improves myocardial function and myocardial perfusion (measured by myocardial contrast echocardiography) and novel vascular risk factors in patients with acute myocardial…
- Trial name
- NCT00237471
- Testing
- Insulin (tight blood glucose control)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Melbourne Health
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited