Clinical trials: Heart Arrest, Out-Of-Hospital
Out-Of-Hospital Cardiac Arrest, In-hospital Cardiac Arrest
RIAC - Registro Italiano Arresti Cardiaci (Italian Registry of Cardiac Arrest)
RIAC - An Observational, Prospective, Multi-centre, Study of Epidemiology, Treatment, and Outcome of Cardiac Arrest in Italy.
- Trial name
- RIAC (NCT03220269)
- Testing
- Out-of-hospital cardiac arrest (OHCA), In-hospital cardiac arrest (IHCA)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Italian Resuscitation Council
Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac
The Use of Mobile Phones in Out of Hospital Cardiac Arrest to Increase Bystander CPR
Death from cardiac disease is one of the most common causes of death in the western world. The majority of these deaths takes place outside hospital as sudden cardiac death.
- Conditions
- Out-of-Hospital Cardiac Arrest, Death, Sudden, Cardiac, Heart Diseases, Ventricular Fibrillation
- Trial name
- RUMBA (NCT01789554)
- Testing
- MLS dispatch for bystander CPR
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest, Resuscitation
Out-of-hospital Cardiopulmonary Resuscitation and AED Feedback
The purpose of this study is to determine whether an online automatic feedback improved CPR quality (No-flow time, compression depth, short-term survival and one year follow up) in this prospective randomised study of…
- Trial name
- NCT00449969
- Testing
- Zoll AED pro
- Where
- Germany
- Volunteers
- 312 people
- Sponsor
- University Hospital Muenster
Out-of-hospital Cardiac Arrest
Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes
Out-of-hospital cardiac arrest (OHCA) is a public health problem, affecting 50,000 people per year in France. Intervention time (initiation of cardiopulmonary resuscitation (CPR) and advanced CPR) are associated with a better…
- Trial name
- CASCADE (NCT04993716)
- Testing
- observational
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Stephane Sanchez
Pain, Out-of-hospital Cardiac Arrest (OHCA)
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest.
- Trial name
- PAINCARE (NCT07564778)
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
The TAME Cardiac Arrest trial will study the ability of higher arterial carbon dioxide (PaCO2) levels to reduce brain damage, comparing giving patients 'normal' to 'slightly higher than normal' blood PaCO2 levels and assessing…
- Trial name
- TAME (NCT03114033)
- Testing
- Targeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 1,700 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiac Arrest
Phase 1 Study of HBN-1
Phase 1 First-in Human randomized, open-label, active control standard of care study of the safety of HBN-1 administered as pharmacologically induced hypothermia as an adjunct to standard of care targeted temperature management…
- Trial name
- NCT04094857
- Testing
- HBN-1
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Hibernaid, Inc
Out of Hospital Cardiac Arrest
Initiation of Cooling by EMS to Promote Adoption of In-hospital Hypothermia in Cardiac Arrest Survivors
This is a large pragmatic, randomized controlled trial comparing pre-hospital initiation of therapeutic hypothermia by Emergency Medical Services (EMS) providers to conventional post-resuscitation care.
- Trial name
- NCT01528475
- Testing
- Pre-hospital cooling
- Where
- 3 sites in Canada
- Volunteers
- 585 people
- Sponsor
- Sunnybrook Health Sciences Centre
Out-of Hospital Cardiac Arrest
Hyperinvasive Approach in Cardiac Arrest
Prague out-of Hospital Cardiac Arrest (OHCA) study is a prospective randomized multicenter clinical study comparing use of prehospital intraarrest hypothermia, mechanical chest compression device, extracorporeal life support…
- Trial name
- NCT01511666
- Testing
- Prehospital mechanical compressions, intraarrest cooling and in hospital ECLS, Standard care
- Where
- Czechia
- Volunteers
- 256 people
- Sponsor
- Charles University, Czech Republic
Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome
Pre-hospital Post ROSC Care: Are we Achieving Our Targets?
Rational: Out of hospital cardiac arrest is a devastating event with a high mortality. Survival rates have increased over the last years, with the availability of AED's and public BLS.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Post Cardiac Arrest Syndrome, Emergency Medical Services
- Trial name
- POP-ROC (NCT04339257)
- Volunteers
- 175 people
- Sponsor
- University Medical Center Groningen
Out-of-Hospital Cardiac Arrest
EMERGEncy Versus Delayed Coronary Angiogram in Survivors of Out-of-hospital Cardiac Arrest
Sudden cardiac death (SCD) remains a major public health issue with a low survival rate. The most common cause of SCD is acute coronary artery occlusion.
- Trial name
- EMERGE (NCT02876458)
- Testing
- Immediate coronary angiogram, Delayed coronary angiogram
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Out-of-Hospital Cardiac Arrest
POHCA Resuscitation: Evaluation of IM Epinephrine
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac…
- Trial name
- PRIME (NCT05166343)
- Testing
- Epinephrine Injection
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Arrest (CA)
The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front…
- Trial name
- VECTORS (NCT07818785)
- Testing
- defibrillator electrode pads
- Volunteers
- 1,500 people
- Sponsor
- Oregon Health and Science University
Emergency Medical Service, Out-of-Hospital Cardiac Arrest
Venous Injection Compared To intraOsseous Injection During Resuscitation of Patients With Out-of-hospital Cardiac Arrest
Overall survival of patients after out-of-hospital cardiac arrest (*OHCA*) is less than 10% worldwide and in Taiwan. Interventions provided by the emergency medical system (*EMS*) before arrival at the hospital are of paramount…
- Conditions
- Emergency Medical Service, Out-of-Hospital Cardiac Arrest, Vascular Access, Intraosseous Access
- Trial name
- VICTOR (NCT04135547)
- Testing
- intra-osseous access vs. intra-venous access
- Where
- Taiwan
- Volunteers
- 1,732 people
- Sponsor
- National Taiwan University Hospital
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Out-of-hospital Cardiac Arrest
Save Hearts in Arizona Registry and Education (SHARE) Project
Evaluation of the impact of bystander CPR, prehospital resuscitation protocols, and hospital post-resuscitation protocols for out-of-hospital cardiac arrest patients in the state of Arizona.
- Trial name
- SHARE (NCT01999036)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- University of Arizona
Out-Of-Hospital Cardiac Arrest
Epidemiological Study of Out-of-hospital Cardiac Arrest in Shenzhen
The epidemiology of out-of-hospital cardiac arrest (OHCA) is a significant public health issue, and large-sample studies on such events within China are relatively limited.
- Trial name
- NCT06896006
- Volunteers
- 19,672 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Cardiac Arrest Due to Trauma (Disorder)
Ultrasound-guidance for Intraosseous Access During Earthquake
The aim of this field report is to describe as the use ultrasound guidance can facilitate the insertion of intraosseous access, during the resuscitation, in the victims of out-of hospital traumatic cardiac arrest
- Trial name
- NCT03491787
- Testing
- Ultrasound guidance
- Volunteers
- 31 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Out-Of-Hospital Cardiac Arrest
AED-delivery Using Drones in Out-of-hospital Cardiac Arrest
Time to defibrillation is the most important predictor of survival in cardiac arrest. Traditional emergency medical system response is often to slow.
- Trial name
- NCT04415398
- Testing
- Automated flying Drone carrying an Automated external defibrillator (AED)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet