Clinical trials: Heart Attack Patients
ST Segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
In STEMI patients undergoing PPCI there is a delayed onset of action of oral P2Y12 receptor inhibitors, including prasugrel and ticagrelor.
- Trial name
- CANTIC (NCT03247738)
- Testing
- Cangrelor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Myocardial Infarction, Acute
Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction
Cardiac-enriched micro-RNAs (miRNAs), micro RNA 208b and 133a(MiR-208b, MiR-133a)) corresponds to the health and disorders of the cardiovascular system. An intron of the cardiac myosin heavy chain gene MYH7 encodes miR-208b.
- Trial name
- NCT05692752
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Islamia University of Bahawalpur
Cardiac Infarct, Cardiac Valve Disease
Frailty, Physical Capacity and Lung Function in Postoperative Cardiac Surgery Patients
The goal of this observational and prospective study is to investigate changes in physical performance, lung function, and respiratory and peripheral muscle strength in patients during the postoperative period following coronary…
- Conditions
- Cardiac Infarct, Cardiac Valve Disease, Fragility, Physical Disability
- Trial name
- NCT06247358
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Coronary Syndromes, Acute Myocardial Infarction
Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in…
- Conditions
- Acute Coronary Syndromes, Acute Myocardial Infarction, Reperfusion Injury
- Trial name
- NCT00627809
- Testing
- Streptokinase, primary percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Acute Coronary Syndrome, Recurrent Myocardial Infarction
Primary Prevention With Statin and Incidence of Recurrent MI and Cardiogenic Shock in Post-ACS Patients
This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of recurrent myocardial infarction, cardiogenic shock and mortality in ACS patients.
- Conditions
- Acute Coronary Syndrome, Recurrent Myocardial Infarction, Cardiogenic Shock
- Trial name
- NCT03596944
- Testing
- Statin
- Where
- Indonesia
- Volunteers
- 145 people
- Sponsor
- Tarumanagara University
Atherosclerosis, Coronary Artery Disease
ARISE - Aggressive Reduction of Inflammation Stops Events
To assess the safety and efficacy of AGI-1067, as compared to placebo, in the treatment of vascular inflammation and atherosclerosis by assessing the reduction in cardiovascular events.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Myocardial Infarction, Unstable Angina
- Trial name
- NCT00066898
- Testing
- AGI-1067
- Where
- 219 sites in United States, Canada and 2 more
- Volunteers
- 6,000 people
- Sponsor
- AtheroGenics
Cardiogenic Shock, ECMO
Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation
Midazolam and propofol are the most used intravenous (IV) sedative agents, but their use is associated with well-known adverse effects such as accumulation, myotoxicity, tachyphylaxis, and unpredictable wake-up time.
- Trial name
- INSEPTION (NCT07099014)
- Testing
- Inahled Isoflurane, Propofol, midazolam
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ST Elevation Myocardial Infarction
Cardiovascular Patient Outcomes and Research Team Primary PCI Registry
The proposed study is a registry of patients treated with primary angioplasty for acute myocardial infarction. The aim of this registry is to define the outcomes of patients treated for acute, ST-segment myocardial infarction…
- Trial name
- CPORT (NCT02201264)
- Where
- 14 sites in United States
- Volunteers
- 6,726 people
- Sponsor
- Johns Hopkins University
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
Acute Myocardial Infarction
COOL AMI EU Pilot Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction
COOL AMI EU Pilot Trial: A Multicenter, Prospective, Randomized Controlled Trial to Assess Cooling as an adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction.
- Trial name
- NCT02509832
- Testing
- Cooling + PCI, PCI only
- Where
- 13 sites in Austria, Estonia and 6 more
- Volunteers
- 100 people
- Sponsor
- ZOLL Circulation, Inc., USA
Myocardial Infarction
The Impact of Text Messaging on Medication Adherence and Exercise Regimen Among Post-myocardial Infarction Patients
The purpose of this study is to assess the impact of text message reminders on adherence to medications and exercise in patients recently discharged from the hospital after a myocardial infarction (MI).
- Trial name
- NCT02783287
- Testing
- Text message reminder for medication adherence, Text message reminder for exercise regimen
- Volunteers
- 84 people
- Sponsor
- Brigham and Women's Hospital
Post MI Left Ventricular Dysfunction
IdeNtifying High riSk Patients Post Myocardial Infarction With REduced Left Ventricular Function Using External Loop Recorders (INSPIRE-ELR Study)
The purpose of the INSPIRE-ELR study is to characterize arrhythmias in post MI low EF (≤35%) patients in the acute phase (at discharge from hospital after index MI) and chronic phase (at 8-10 weeks after index MI) and to…
- Trial name
- INSPIRE-ELR (NCT01995552)
- Testing
- External Loop Recorder
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Medtronic BRC
Acute Myocardial Infarction
To Investigate the Role of Upstream High Dose Statin in STEMI
This is a double-blinded randomized placebo controlled trial investigating the role of upstream 80mg Atorvastastin-calcium in patients undergoing percutaneous intervention for acute STEMI.
- Trial name
- IMPRES (NCT01050348)
- Testing
- Atorvastatin calcium
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- The Western Pennsylvania Hospital
Patent Foramen Ovale, Stroke
Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA
This study is a prospective, multicenter, randomized, controlled, single-blind, investigator-driven, non-profit clinical trial designed to compare the safety and efficacy of the Cocoon PFO Occluder with the Amplatzer PFO Occluder…
- Conditions
- Patent Foramen Ovale, Stroke, Transient Ischemic Attack (TIA)
- Trial name
- SAFE-PFO (NCT07380490)
- Testing
- PFO Closure procedure
- Where
- Germany
- Volunteers
- 1,260 people
- Sponsor
- Giuseppe Tarantini
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Coronary Artery Disease, Myocardial Infarction
Foundation Model for Post-MI Cardiovascular Event Alert Using Huawei Watch
The goal of this randomized controlled trial is to evaluate whether a HUAWEI smartwatch integrated with a foundation model can enhance daily monitoring and management of AMI patients during outpatient cardiac rehabilitation after…
- Trial name
- NCT07395648
- Testing
- Smartwatch + AI assisted, Smartwatch only, Conventional care
- Volunteers
- 1,050 people
- Sponsor
- Tongji Hospital
Myocardial Infarction
Value of Abciximab in Patients With AMI Undergoing Primary PCI After Clopidogrel Pretreatment (BRAVE 3)
The purpose of this study is to assess whether abciximab is associated with additional benefit in patients with AMI treated with PCI after high dose clopidogrel loading.
- Trial name
- NCT00133250
- Testing
- Abciximab
- Where
- 5 sites in Austria, Germany
- Volunteers
- 800 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Myocardial Infarction, Acute Coronary Syndrome
Impact at One Year of a Secondary Prevention Educational Program on Cardiovascular Risk Factors
In secondary prevention, the beneficial role of cardiac rehabilitation programs after myocardial infarction, percutaneous coronary intervention or coronary artery bypass is now well established.
- Trial name
- OLIMPIC (NCT00758810)
- Where
- 4 sites in France
- Volunteers
- 354 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Coronary Syndrome (ACS)
Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL
CTQJ230A1US13 is a randomized, double-blind, placebo-controlled, multicenter phase IIIb study designed to evaluate the efficacy, safety, tolerability, and coronary plaque effects of early pelacarsen (TQJ230) initiation in…
- Trial name
- NCT07625306
- Testing
- Pelacarsen
- Sponsor
- Novartis Pharmaceuticals
Calcified Atheroma, Coronary Artery Disease
ShOckwave ballooN or Atherectomy With Rotablation in Calcified Coronary Artery Lesions, the SONAR Trial
Percutaneous coronary interventions (PCI) is intended to relieve myocardial ischemia by improving blood flow in the epicardial coronary arteries.
- Trial name
- SONAR (NCT05208749)
- Testing
- Rotablation of shockwave
- Where
- Belgium
- Volunteers
- 170 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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