Clinical trials: Heart Diseases, Coronary
Aortic Valve Stenosis
X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development
Background: Computed tomography (CT) creates three-dimensional images based on X-ray imaging. CT is useful for determining treatment approaches for certain diseases, such as calcific aortic stenosis (narrowing of the aorta…
- Trial name
- NCT00965679
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke
PERIOP 2 - A Safety and Effectiveness of LMWH vs Placebo Bridging Therapy for Patients on Long Term Warfarin Requiring Temporary Interruption of Warfarin.
The purpose of the study is to determine the effectiveness and safety of LMWH postoperative bridging therapy (standard of care) versus postoperative placebo bridging therapy (experimental arm)for patients with mechanical heart…
- Trial name
- NCT00432796
- Testing
- Dalteparin
- Where
- 8 sites in Canada, India
- Volunteers
- 1,473 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease
ABSORB PHYSIOLOGY Clinical Investigation
The target enrollment goal for the trial was to enroll 36 subjects. However due to a challenging protocol inclusion/ exclusion criteria, only one subject was enrolled since the trial was initiated in June 2011.
- Trial name
- NCT01308346
- Testing
- Bioabsorbable Vascular Solutions Everolimus Eluting Coronary Stent System (BVS EECSS), XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
- Where
- 6 sites in Australia, China and 2 more
- Volunteers
- 1 people
- Sponsor
- Abbott Medical Devices
Chronic Heart Failure, Hypertension
Nebivolol Versus Carvedilol in Patients With Heart Failure
BACKGROUND Beta-blockers improve left ventricular (LV) systolic function and prognosis in patients with chronic heart failure. Both carvedilol and nebivolol have hemodynamic and clinical benefits in chronic heart failure (CHF)…
- Trial name
- NCT00511888
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- IRCCS San Raffaele
Atrial Flutter, Atrial Fibrillation
Cryoballoon Pulmonary Venous Isolation in Patients Referred for Typical Atrial Flutter Ablation
Background: Atrial fibrillation is frequently associated with typical atrial flutter in clinical practice. If the radical treatment of atrial flutter by radiofrequency catheter is achieved in most cases without recurrence, it…
- Trial name
- PAF CRIOBLAF (NCT01521988)
- Testing
- Atrial flutter ablation, Atrial flutter ablation and pulmonary vein isolation
- Where
- 15 sites in France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Rouen
Acute Myocardial Infarction
Study of Rehabilitation Therapy on Patients After Acute Myocardial Infarction
The purpose of this study is to determine whether exercise rehabilitation can reduce mortality, reinfarction or heart failure of patients after acute myocardial infarction.
- Trial name
- NCT00725088
- Testing
- Exercise training
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Heart Failure
BAROSTIM THERAPY™ In Heart Failure With Preserved Ejection Fraction
The purpose of this registry (NCT02876042) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO system in the commercial setting in subjects recently implanted under the CE-Marked indication for resistant…
- Trial name
- HFpEF (NCT02876042)
- Testing
- BAROSTIM NEO™ System
- Where
- 13 sites in Germany
- Volunteers
- 11 people
- Sponsor
- CVRx, Inc.
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University
Depression Disorder, fMRI Research
Modulatory Effects of Personalized Transcranial Magnetic Stimulation (TMS) on Heart-Brain Coupling in Individuals With Depressive Tendencies
This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in…
- Conditions
- Depression Disorder, fMRI Research, Heart-Brain Coupling
- Trial name
- NCT07753473
- Testing
- DLPFC-insula TMS, DLPFC-sgACC TMS, 10-20 F3 TMS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xidian University
Atherosclerosis
Study Of The Effects Of SB 480848 (Darapladib) On The Electrical Conduction Of The Heart
This is a study to assess the effects of darapladib on the cardiac conduction of the heart as compared to placebo and moxifloxacin. This a four period crossover design with each period lasting about 10 days.
- Trial name
- NCT00411073
- Testing
- Darapladib
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease, Angina Pectoris
An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery
The primary objective of this study is to evaluate sternal bone healing following a full median sternotomy versus standard of care for sternal closure with wire cerclage.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Cardiac Valve Disease
- Trial name
- SB (NCT01783483)
- Testing
- SternaLock Blue closure system, Suture Wire
- Where
- 12 sites in United States
- Volunteers
- 236 people
- Sponsor
- Zimmer Biomet
POAF, Atrial Fibrillation
CardiaMend and Amiodarone for the Prevention of POAF
The principal purpose of this investigator-initiated trial is to study the use of the CardiaMend device soaked in the anti-arrhythmic drug amiodarone, and how it may decrease the development of atrial fibrillation in patients…
- Trial name
- NCT05641883
- Testing
- CardiaMend with antiarrhythmic
- Volunteers
- 30 people
- Sponsor
- Saint Alphonsus Regional Medical Center
Atrial Fibrillation
STOP Persistent AF
To demonstrate safety and effectiveness of the Arctic Front Advance™ and Freezor MAX® Cardiac CryoAblation Catheters for the treatment of drug refractory recurrent symptomatic persistent atrial fibrillation (AF).
- Trial name
- NCT03012841
- Testing
- Arctic Front Advance Cardiac CryoAblation Catheter
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 186 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Adherence to Personalized EBM Anticoagulant Treatment in Patients at High Risk for Stroke
Personalized Evidence-based Medicine in Patients With Atrial Fibrillation
A retrospective analysis
- Trial name
- NCT04774341
- Testing
- anticoagulation treatment
- Where
- Russia
- Volunteers
- 4,200 people
- Sponsor
- Center of Personalized Medicine, Pirogova
Angina Pectoris, Coronary Microvascular Disease
Comprehensive Treatment of Angina in Women With Microvascular Dysfunction
Angina is the most common symptom of coronary heart disease among women but unlike men most women do not have stenosis of the coronary arteries.
- Trial name
- CORA (NCT02910154)
- Testing
- Diet, Training, Medication (with statin and ACE-inhibition)
- Where
- 2 sites in Denmark
- Volunteers
- 62 people
- Sponsor
- Bispebjerg Hospital
Cardiovascular Disease
Smart Heart Study: Cognitive Benefits of Cardiac Rehabilitation
The proposed study will be the first to examine whether changes in blood flow patterns within the brain account for the possible cognitive benefits of CR.
- Trial name
- NCT00320905
- Testing
- Observational
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Summa Health System
Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction
The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main…
- Trial name
- REDEFINE-CMD (NCT07337005)
- Testing
- Invasive coronary physiological measurements
- Volunteers
- 100 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Artery Disease
Cangrelor Ticagrelor Transition Study
To demonstrate that patients treated with cangrelor can be directly switched to oral ticagrelor and that patients treated with ticagrelor can be switched to cangrelor without a significant decrease in the extent of inhibition of…
- Trial name
- NCT01766466
- Testing
- cangrelor, Ticagrelor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Medicines Company
Cardiovascular Diseases, Hypertension
Clinical Trial of Dietary Protein and Blood Pressure
The purpose of this study is to examine the effect of dietary protein supplements on high blood pressure (BP).
- Conditions
- Cardiovascular Diseases, Hypertension, Heart Diseases
- Trial name
- ProBP (NCT00046566)
- Testing
- Soy protein-milk protein-carbohydrate, Milk protein-carbohydrate-soy protein, Carbohydrate-soy protein-milk protein
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Tulane University
Atrial Fibrillation, Heart Failure
NT-proBNP Measurements to Rule-out Heart Failure Among Patients With Atrial Fibrillation: A Prospective Clinical Study
This study aims to investigate N-terminal pro brain natriuretic peptide (NT-proBNP) as a biomarker to rule out heart failure in patients with atrial fibrillation. Atrial fibrillation and heart failure often co-exist.
- Trial name
- ProAF (NCT04125966)
- Where
- Denmark
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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