Clinical trials: Heart Failure，Congestive
Cardiogenic Shock
Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac Output
This is a prospective, randomized, non-blinded, single-center efficacy study of acutely decompensated heart failure patients with reduced ejection fraction (HFrEF), low cardiac index (<2.2) as determined by pulmonary artery…
- Trial name
- PARAVLO-HF (NCT04206865)
- Testing
- Sacubitril-Valsartan, Standard Oral Vasodilators
- Where
- United States
- Sponsor
- The Cleveland Clinic
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Sleep Apnea, Mixed, Heart Failure
Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability
Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a condition where the upper airway partially collapses and closes. This can lead to sleep problems including low oxygen levels, poor sleep, elevated carbon dioxide levels in…
- Trial name
- NCT03890939
- Testing
- BiPAP AutoSV Advanced System One, Dreamstation BiPaP AutoSV, ResMed S7 VPAP Adapt Device
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Chronic Heart Failure
Effects of Amlodipine in the Management of Chronic Heart Failure
Patients with congestive heart failure are usually treated with a combination of an ACE inhibitor (or an AT1 blocking agent), a diuretic and a beta-blocker.
- Trial name
- NCT00151619
- Testing
- Amlodipine
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Rennes University Hospital
Heart Failure
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
Working Hypothesis: a treatment with thiamine improves functional status and heart function of patients with congestive heart failure when on a diuretic treatment.
- Trial name
- NCT00770107
- Testing
- Thiamine
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Luzerner Kantonsspital
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Heart Failure
Mobile Health Monitoring Solution for Heart Failure Patients
Heart Failure (HF) affects 5.7 million Americans and is the only major cardiovascular disorder on the rise. The primary aim of this study is to formally study the combined effects of several different tele-health modalities, all…
- Trial name
- NCT02594007
- Testing
- SEEQ, Cardiocom, DocView
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Atlantic Health System
Heart Failure, Diastolic
Optimized Management of Comorbidity in Heart Failure With Preserved Ejection Fraction in the Elderly (>60 Years)
Growing recognition of the importance of co-morbidities in Heart Failure with Preserved Ejection Fraction (HFPEF) has led to the realization that rather than being a distinct disease entity, HFPEF may represent a spectrum of…
- Trial name
- OPTIMIZE-HFPEF (NCT02425371)
- Testing
- Screening and treatment of comorbidities
- Where
- Sweden
- Volunteers
- 410 people
- Sponsor
- Göteborg University
ST Elevation Myocardial Infarction
Shanghai ST-segment Elevation Myocardial Infarction Cohort
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and…
- Trial name
- NCT05450757
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Acute Heart Failure
Acute Heart Failure - COngestion Discharge Evaluation
Acute heart failure (AHF) is a major public health problem, associated with a 40% risk of death or re-hospitalisation at 3 months.
- Trial name
- AHF-CODE (NCT04332692)
- Testing
- Clinical examination centered on congestion, Cardiac, pulmonary, peritoneal, jugular, renal Doppler ultrasounds and liver elastography, Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Cardiogenic Shock
Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
The aim of the study is to demonstrate the superiority of early intra-aortic balloon pump implantation at admission over local clinical practice (pharmacological only) in acute decompensated heart failure patients with…
- Trial name
- Altshock-2 (NCT04369573)
- Testing
- Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Cardiovascular Diseases, Delirium
Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
Patients are part of a family network. When any person in a family becomes critically unwell and requires the assistance of an Intensive Care Unit (ICU), this has an impact on all members of that family.
- Conditions
- Cardiovascular Diseases, Delirium, Critical Illness, Intensive Care Unit Delirium
- Trial name
- VINCI (NCT04538469)
- Testing
- COVID visitation restrictions
- Volunteers
- 1,000 people
- Sponsor
- University of Glasgow
Heart Failure
A Study Designed to Assess the Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD5462 and the Absolute Bioavailability of AZD5462
A study to investigate how the body breaks down and gets rid of the test medicine, AZD5462. To help investigate this, the test medicine is radiolabelled, which means that the test medicine has a radioactive component (carbon-14)…
- Trial name
- NCT06989983
- Testing
- AZD5462 film-coated tablet, [14C]AZD5462 Solution for Infusion, [14C]AZD5462 Oral Solution
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Heart Failure
Rivaroxaban Once Daily Versus Dose-adjusted Vitamin K Antagonist on the Biomarkers in Acute Decompensated Heart Failure and Atrial Fibrillation (ROAD HF-AF)
Vitamin K antagonists (VKAs) are used to reduce the risk of stroke (cerebral vascular dysfunction) in AF patients. However, VKAs interact with drugs/food and the drug level is influenced by worsening of renal function, liver…
- Trial name
- NCT03490994
- Testing
- Rivaroxaban, Warfarin + LMWH
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
Heart Failure, Diastolic Heart Failure
Heart Failure and Postoperative Outcome in Surgery - a National Registry Study
The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure.
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure
- Trial name
- NCT07634822
- Where
- 2 sites in Sweden
- Volunteers
- 2,200,000 people
- Sponsor
- Umeå University
Coronary Heart Disease, Stroke
The Copenhagen City Heart Study
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population.
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer
- Trial name
- CCHS (NCT02993172)
- Volunteers
- 23,891 people
- Sponsor
- Bispebjerg Hospital
Heart Failure, Atrial Fibrillation
CONTAK RENEWAL 3 AVT
The RENEWAL 3 AVT device is designed to treat patients suffering from HF, with a history of or at risk of developing atrial and ventricular arrhythmias
- Trial name
- NCT00158977
- Testing
- CONTAK RENEWAL 3 AVT
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Boston Scientific Corporation
Congestive Heart Failure
Paced And Sensed Electrical Delay in CRT Therapy (PASED CRT)
Cardiac resynchronization therapy (CRT) is a well established clinical therapy for patients with symptomatic left ventricular systolic dysfunction and electrocardiographic QRS duration of 120 ms or greater.
- Trial name
- PASED (NCT02803775)
- Testing
- CRT Algorithm
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Deborah Heart and Lung Center
Ventricular Arrythmia, Lead
Safety and Electrical Performance Evaluation of INVICTA Leads Models Equipped With DF4 Connector
The primary objective of this study is to assess the safety and key electrical performance of the INVICTA leads equipped with DF4 connector: ACTIVE fixation type models (single and dual coil: INVICTA 1CR, INVICTA 2CR) and PASSIVE…
- Conditions
- Ventricular Arrythmia, Lead, ICD, Heart Failure
- Trial name
- FRIENDS (NCT03766919)
- Testing
- Implant of the INVICTA lead
- Where
- 10 sites in France, Italy and 2 more
- Volunteers
- 33 people
- Sponsor
- MicroPort CRM
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