Clinical trials: Heart Failure
Vascular Disease, Cardiovascular
A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action.
A preventive, multidisciplinary primary care intervention organized around a therapeutic garden: Acceptability to patients suffering from cardio-neurovascular pathology and to those involved in the action.
- Conditions
- Vascular Disease, Cardiovascular, Atrial Fibrillation (AF), Heart Failure NYHA Class II
- Trial name
- ArTERRE (NCT06646601)
- Testing
- Intervention of prevention
- Where
- France
- Volunteers
- 157 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pulmonary Hypertension
Screening and Phenotyping of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction .
Left-sided heart failure (HF) is known to cause pulmonary hypertension (PH), but the development and severity of PH in HF is highly variable, and contributing factors are not fully understood.
- Trial name
- NCT07082400
- Testing
- right heart catheter
- Volunteers
- 100 people
- Sponsor
- Sohag University
Heart Failure, Systolic, Depression
Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Depression is highly prevalent among patients with heart failure (HF) and associated with lower levels of health-related quality of life and physical functioning, and higher risk of rehospitalization and mortality, and higher…
- Conditions
- Heart Failure, Systolic, Depression, Cardiovascular Disease
- Trial name
- NCT02044211
- Testing
- Collaborative Care for Heart Failure, Collaborative Care for Depression
- Where
- United States
- Volunteers
- 756 people
- Sponsor
- University of Pittsburgh
Heart Failure
Quantifying Congestion by Ultrasound
The investigators will determine the feasibility of identifying and quantifying changes in interstitial and intravascular congestion by imaging in participants with heart failure.
- Trial name
- QUEST-HF (NCT05090137)
- Testing
- Diuretics
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Heart Failure, Cardiac Failure
Blood Pressure Reduction in Heart Failure
Previous studies have demonstrated a direct association between blood pressure level and cardiovascular risk. However in patients with heart failure this association is considered controversial.
- Conditions
- Heart Failure, Cardiac Failure, Congestive Heart Failure
- Trial name
- REPIC (NCT01255475)
- Testing
- Hydralazine/amlodipine
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Heart Failure
Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients
The purpose of this trial is to obtain a pharmacokinetic profile (i.e. amount of drug in the blood over time) of Omecamtiv mecarbil in patients with stable heart failure.
- Trial name
- NCT01077167
- Testing
- Omecamtiv mecarbil
- Sponsor
- Cytokinetics
Heart Failure
Hemodynamic Effects of Modulating Circulating Ketone Bodies With 1,3-butanediol
Heart Failure (HF) is a major public health issue affecting 1-2% of the Western population and the lifetime risk of HF is 20%. Despite major improvements in the management and care of patients with HF, the 1-year mortality in…
- Trial name
- KETO-BD (NCT05768100)
- Testing
- 1,3-Butanediol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Congestive
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00328692
- Testing
- rolofylline
- Volunteers
- 932 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Cardiovascular Disease, Heart Failure
Integration of Chronic Disease Rehabilitation Services Into Primary Care
The aim of PR1MaC is to establish a clinical intervention that will adapt and permanently integrate rehabilitation services into primary care settings, which would be the reference point in the health care system for people with…
- Conditions
- Cardiovascular Disease, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- PR1MaC (NCT01319656)
- Testing
- Support, management, educational, counselling, follow-up
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- Martin Fortin
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Heart Failure
Assessment and Monitoring of Patients in Medium-term Heart Transplant Candidates Undergoing Low-intensity Exercise
Objectives: To study the behavior and cardiovascular safety protocol to the front low-intensity exercise in patients with heart failure (HF) severe, awaiting heart transplantation.
- Trial name
- NCT01160939
- Testing
- low intensity exercise
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- Federal University of São Paulo
Kidney Failure
FREquent DIalysis & Markers of Cardiac Strain and Injury, Physical Fitness, Habitual Physical Activity & Quality of Life
Individuals with kidney failure are kept alive using dialysis machines designed to remove toxic substances and excess fluid from the blood.
- Trial name
- FREDI-CAL (NCT03925454)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Obstructive Sleep Apnea, Heart Failure
Mandibular Advancement Device for Treatment of Obstructive Sleep Apnea and Its Impact on Cardiac Remodeling
Primary aim: The MOSAIC trial aims to assess the impact of a mandibular advancement device (MAD) on Apnea-Hypopnea Index (AHI) in Asian patients with Heart Failure with reduced Ejection Fraction (HFrEF) and obstructive sleep…
- Trial name
- MOSAIC (NCT02948894)
- Testing
- Mandibular advancement device
- Where
- 2 sites in Singapore
- Volunteers
- 100 people
- Sponsor
- National University of Singapore
Cardiomyopathies
Outcome of Cardiomyopathic Adults Admission in ICU.
To study the outcome of the cardiac function, and clinical status of the patiants with cardiomyopathy who are admitted in the I.C.U.
- Trial name
- NCT05567445
- Testing
- Echocardiography, CBC, Liver function, kideny function
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure
Heart Failure and Sleep Disordered Breathing
The purpose of this study is to analyze and summarize the characteristics of arrhythmia and heart rate variability of Chinese patients with three different types of heart failure combined with sleep disordered breathing based on…
- Trial name
- NCT05892172
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yihui Kong
Heart Failure, Heart Failure NYHA Class III
HEart fAiluRe evaluaTion Questionnaire
The "four-point" questionnaire by Severo and his associates was weighted in 2011 in the Portuguese population and aims to characterize the severity of the symptoms of heart failure by providing a way to minimize the reliability…
- Conditions
- Heart Failure, Heart Failure NYHA Class III, Heart Failure NYHA Class II, Heart Failure NYHA Class I
- Trial name
- HEART (NCT03895073)
- Testing
- healthy volunteers
- Where
- Greece
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- John Parissis
Heart Failure, Right Ventricular Dysfunction
Mitigating Post-Op RV Dysfunction After LVAD Implantation
This project evaluates right ventricle (RV) protective strategies after left ventricular assist device (LVAD) implantation.
- Conditions
- Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- NCT05758194
- Testing
- Standardized RV Management, Usual Care RV Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Shock, Cardiogenic, Heart Failure
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
- Conditions
- Shock, Cardiogenic, Heart Failure, Acute Myocardial Infarction
- Trial name
- NCT00604331
- Testing
- Pyruvate
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Herzzentrum Goettingen
Heart Failure, Congestive, Heart Decompensation
A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels
The purpose of this safety study is to evaluate NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure), in subjects with worsening congestive heart failure…
- Trial name
- NCT00271557
- Testing
- nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.