Clinical trials: Heart Failure with Reduced Ejection Fraction HFrEF
Heart Failure With Reduced Ejection Fraction
Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients
This pilot study will test the feasibility of a novel digital health technology-enabled platform, HekaHeart, developed to facilitate comprehensive medical management, including medication initiation, titration, e-prescription…
- Trial name
- HekaHeart POC (NCT06433687)
- Testing
- HekaHeart platform medication management and remote monitoring
- Where
- 2 sites in United States
- Sponsor
- Yale University
Chronic Heart Failure With Reduced Ejection Fraction
A Study of LY3461767 in Participants With Chronic Heart Failure With Reduced Ejection Fraction
The main purpose of this study is to determine the tolerability and safety of LY3461767 with any side effects that might be associated with it.
- Trial name
- NCT04840914
- Testing
- LY3461767
- Where
- 7 sites in United States, Japan
- Volunteers
- 44 people
- Sponsor
- Eli Lilly and Company
Defibrillators, Implantable, Heart Failure With Reduced Ejection Fraction
Multi-centre Observational Registry on Patients With Implantable Devices Remotely Monitored
Multicentric, observational, retrospective registry including patients underwent implantable device implantation (pacemaker or ICD) for any indication in the period from 2009 to 2016, followed by remote monitoring.
- Conditions
- Defibrillators, Implantable, Heart Failure With Reduced Ejection Fraction, Arrythmia, Pacemaker
- Trial name
- IMPLANTED (NCT03061747)
- Testing
- Assesment of outcome of implantable device patients
- Where
- 6 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Heart Failure With Reduced Ejection Fraction
Finding Gab in the Treatment of Heart Failure in Assiut University Hospital
Analyze the epidemiology and outcome of all patients with heart failure with reduced ejection fraction (HFrEF) presented to Asyut university hospital (AUH) and to identify factors associated with mortality and all-cause…
- Trial name
- NCT03877887
- Testing
- echo cardiogram
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Failure, Heart Failure With Preserved Ejection Fraction
Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE)
Acute heart failure (AHF) is defined as rapid onset or rapid worsening of typical signs and symptoms of heart failure (HF) according to the 2016 European Society of Cardiology Guidelines.
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- FUTURE-HIT (NCT05204238)
- Testing
- Transthoracic Echocardiography
- Where
- 31 sites in Australia, Belgium and 10 more
- Volunteers
- 998 people
- Sponsor
- University of Siena
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases
- Trial name
- The PULSE-LHD (NCT07214376)
- Testing
- Pulmonary Artery Denervation (PADN)
- Where
- 18 sites in United States, China
- Volunteers
- 750 people
- Sponsor
- Pulnovo Medical, Inc.
HFrEF - Heart Failure With Reduced Ejection Fraction, Myocardial Infarction (MI)
Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
The effects of vericiguat on cardiac remodeling in patients with chronic stable heart failure after myocardial infarction have not been reported.
- Trial name
- HFrEF (NCT06717204)
- Testing
- Vericiguat Oral Tablet [Verquvo], Prescription Drugs
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
This was a retrospective observational cohort study using patient data from the Get With The Guideline-Heart Failure (GWTG-HF) registry linked to Medicare Fee-for-Service (FFS) claims.
- Trial name
- NCT06671314
- Where
- United States
- Volunteers
- 42,494 people
- Sponsor
- Novartis
Chronic Heart Failure With Reduced Ejection Fraction
Efficacy and Safety of QiShen YiQi Dripping Pills in Chronic Heart Failure
This study will evaluate the efficacy and safety and the best effective dose of QiShen YiQi Dripping Pills in the treatment of chronic heart failure with decreased ejection fraction of CHD (Qi deficiency and blood stasis…
- Trial name
- NCT04983043
- Testing
- Low dose QiShen YiQi Dripping Pills 3 bags, High dose QiShen YiQi Dripping Pills 3 bags
- Where
- 23 sites in China
- Volunteers
- 228 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Heart Failure With Reduced Ejection Fraction
Immediate Release Versus Slow Release Carvedilol in Heart Failure
Assessment of clinical effect and treatment quality of immediate release carvedilol (IR) versus slow release carvedilol (SR) in patients with HFrEF
- Trial name
- SLOW-HF (NCT03209180)
- Testing
- CarVeDilol-SR (Slow Release), Carvedilol IR (Immediate Release)
- Where
- 13 sites in South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Bundang Hospital
Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-Defibrillators
This prospective observational study evaluates whether circulating small non-coding RNAs, particularly microRNAs, are associated with ventricular arrhythmias in patients with post-myocardial infarction heart failure who have an…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Ventricular Arrhythmia, Ischemic Cardiomyopathy
- Trial name
- NCT07795892
- Testing
- Circulating Small RNA Profiling
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- University of Rzeszow
Heart Failure With Reduced Ejection Fraction, Renal Insufficiency
Safety and Efficacy of High Protein Diet Versus GFR Based Protein Diet in Heart Failure Patients With Renal Insufficiency
Effect of high calorie high protein diet versus high calorie,glomerular filtration rate (GFR) based protein intake in non-obese advanced HF patients will be assessed.
- Trial name
- GFR (NCT03213821)
- Testing
- protein intake
- Volunteers
- 100 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Heart Failure With Reduced Ejection Fraction
EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot
Evolocumab has been able to reduce the incidence of cardiovascular events in patients that had at least one cardiovascular risk factor [28].
- Trial name
- EVO-HF (NCT03791593)
- Testing
- Evolocumab
- Where
- 3 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
Congenital Heart Disease, Heart Failure
" Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "
The treatment of adult patients with congenital heart disease (ACHD) and heart failure (HF) represents a great challenge since, to date, there is no standardized guideline for this specific population.
- Conditions
- Congenital Heart Disease, Heart Failure, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT05580510
- Testing
- Sacubitril 49 MG / Valsartan 51 MG [Entresto] BID, Empagliflozin 10 MG OD
- Where
- Mexico
- Volunteers
- 160 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Heart Failure With Reduced Ejection Fraction
Exercise and NO in HFrEF
Heart disease is the leading cause of death in the United States, accounting for one in every four deaths in 2010 and costing over $300 billion annually in health care, medication, and lost productivity.
- Trial name
- NCT03136029
- Testing
- Antioxidant, Tetrahydrobiopterin (BH4), Exercise training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- VA Office of Research and Development
Heart Failure With Reduced Ejection Fraction
Benefits of Empagliflozin in Patients With Heart Failure and Reduced Ejection Fraction Without Diabetes Mellitus
The study is a short to mid-term randomized single-blind placebo controlled study that aimed to detect the effects of empagliflozin (a sodium-glucose cotransporter-2 inhibitor) compared to placebo on LV end-diastolic and…
- Trial name
- HFrEF (NCT06632561)
- Testing
- Empagliflozin 10 mg
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Ashraf Wasfy Beshay Aziz
Heart Failure With Reduced Ejection Fraction, Renal Insufficiency, Chronic
SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency
In the treatment of heart failure (HF), SGLT-2 inhibitor (SGLT-2i) can significantly improve the clinical outcome and quality of life related to HF.
- Trial name
- NCT05737186
- Testing
- SGLT-2 inhibitor
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Peking University People's Hospital
Patient Engagement, Medication Optimization
Electronic Health Record-leveraged, Patient-centered, Intensification of Chronic Care for HF
The EPIC-HF study will test the effectiveness of a patient empowerment and activation for optimization of Heart Failure with reduced Ejection Fraction (HFrEF) medication plans.
- Conditions
- Patient Engagement, Medication Optimization, Heart Failure With Reduced Ejection Fraction, Patient Activation
- Trial name
- EPIC-HF (NCT03334188)
- Testing
- Patient engagement materials, No Intervention--Usual Care
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- University of Colorado, Denver
Heart Failure With Reduced Ejection Fraction
Home Outpatient Monitoring and Engagement to Predict HF Exacerbation
The HOME PREDICT HF study looks at new ways to predict hospitalizations for heart failure. We will use a set of devices at home and surveys to collect information about patient's health.
- Trial name
- Home Predict (NCT03479424)
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of Sacubitril/Valsartan (Sac/Vals) compared to no initiation of the drug in patients with transthyretin cardiac amyloidosis…
- Trial name
- SAVA-TTR (NCT06712030)
- Testing
- Sacubitril / Valsartan
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Puerta de Hierro University Hospital