Clinical trials: Heart Infarction
Myocardial Infarction
A Study of NP-011 in Healthy Volunteers
This is a Phase 1, randomised, double-blind, placebo-controlled, single ascending dose (SAD) and multiple ascending dose (MAD) study to evaluate the safety, tolerability, and pharmacokinetic of NP-011 in healthy volunteers.
- Trial name
- NCT05387499
- Testing
- NP-011 (Single Ascending Dose Phase), NP-011 (Multiple Ascending Dose Phase)
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nexel Co., Ltd.
Diagnoses Disease
Reference Interval Validation of High-Sensitivity Cardiac Troponin T Assay in Thai Population
The investigators aimed to study the cut-off of high sensitivity troponin T using SYSMEX HLSCL Machine in Thai population at percentile 99.
- Trial name
- NCT03968016
- Testing
- SYSMEX HLSCL
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
HIV/AIDS, Myocardial Infarction
Inflammation and Cardiovascular Health in Women
Systemic immune activation and inflammation are believed to play a significant role in the development and clinical course of myocardial infarction (MI).
- Trial name
- NCT04224181
- Testing
- Cardiac PET, 99mTc-tilmanocept SPECT/CT, Contrast Enhanced Coronary and Aortic Computed Tomography Angiography
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
STEMI - ST-segment Elevation Myocardial Infarction
Metabolic Characteristics of Plasma OxPLs in STEMI Patients.
The goal of this observational study is to investigate the structural composition and metabolic characteristics of OxPLs in ST-segment elevation myocardial infarction(STEMI) patients.
- Trial name
- NCT07382700
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Myocardial Infarction
Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness
is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients
- Trial name
- NCT03308539
- Testing
- echocardiography and cardiac magnetic resonance
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Osama Fekry
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Corronary Death, Intracerebral Haemorrhage
- Trial name
- IP4 (NCT01937065)
- Testing
- No treatment
- Where
- United Kingdom
- Volunteers
- 1,937,360 people, healthy volunteers welcome
- Sponsor
- University College, London
Myocardial Infarction, Thrombosis
CES1 Crossover Trial of Clopidogrel and Ticagrelor
The purpose of this investigation is to evaluate when genetic variation in the carboxylesterase 1 (CES1) gene influences antiplatelet therapy response, as assessed by ex vivo platelet aggregometry, in healthy participants treated…
- Conditions
- Myocardial Infarction, Thrombosis, Platelet Dysfunction
- Trial name
- NCT03161678
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Premature Myocardial Infarction in Young Egyptian Patients
SIRT1 Gene Polymorphism With Premature Myocardial Infarction in Young Egyptian Patients
This is an observertional study aimed at Study the association of SIRT1(rs7069102 ) Gene polymorphism with premature myocardial infarction in young Egyptian patients
- Trial name
- SIRT1 (NCT05160844)
- Where
- Egypt
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Sohag University
Stroke, Acute Myocardial Infarction
Stroke Prediction Through Internet Search Queries
Cerebrovascular disease (stroke) is a leading cause of mortality and disability. Common risk assessment tools for stroke are based on the Framingham equation, which relies on traditional cardiovascular risk factors (e.g.…
- Trial name
- NCT04755959
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Heart Disease, Acute Myocardial Infarction
Research on the Diagnostic Value of Machine Learning Model Based on Clinical Data in Patients With Coronary Heart Disease
Based on the clinical data of patients, a machine learning model for coronary heart disease diagnosis was established to evaluate whether the model could improve the accuracy of coronary heart disease diagnosis, and to evaluate…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Angina
- Trial name
- NCT05018715
- Testing
- Machine learning model diagnosis
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xiang Ma
Cardiovascular Diseases, Myocardial Infarction
Subclinical Cardiovascular Disease in Psoriatic Disease
This study will look at how chronic inflammation seen in psoriatic disease translates into the increased atherosclerotic and thrombotic risk and how treatment reduces this CVD risk.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Atherosclerotic Cardiovascular Disease, Thrombotic Vascular Disease
- Trial name
- NCT03228017
- Testing
- Aspirin and/or Atorvastatin
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Ischemic Heart Disease
Door-to-door Survey of Cardiovascular Health, Stroke and Ischemic Heart Disease in Atahualpa
The aim of the Atahualpa project is to evaluate the cardiovascular (CVH) status of the inhabitants of a rural village of coastal Ecuador as well as to determine the prevalence and retrospective incidence of stroke and ischemic…
- Trial name
- TAP (NCT01627600)
- Where
- 2 sites in Ecuador
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Myocardial Infarction
Anxiety, Stress and Pain & Myocardial Infarction
People often experience the acute phase of a myocardial infarction as a stressful and traumatic event that seems lifethreatening.
- Trial name
- NCT04130269
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction
The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction
300 STIMI patients with LV systolic dysfunction will be divided into two equal groups (Group I (Study arm, n=150); will receive dapagliflozin plus conventional therapy and group (II) Control arm (n=150); will receive conventional…
- Trial name
- NCT05045274
- Testing
- Dapagliflozin 10Mg Tab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ear/*Abnormalities, Risk Factor
Earlobe Crease as Risk Factors of Acute Myocardial Infarction in Chinese Population
The purpose of this study is to explore the earlobe crease as a risk factor of acute myocardial infarction (AMI)in the Chinese population, combined with other risk factors, to predict high risk patients with coronary heart…
- Trial name
- ELC-AMI-CHN (NCT02637661)
- Testing
- earlobe crease positive, earlobe crease negative
- Where
- China
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Jing Qi
Myocardial Infarction, Inflammation
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
Oxygen treatment is widely used in acutely ill patients. In particular, oxygen treatment is routinely used in acute coronary syndrome (ACS) patients with suspected acute myocardial infarction and variably recommended in…
- Conditions
- Myocardial Infarction, Inflammation, Acute Coronary Syndrome (ACS), Reperfusion Injury
- Trial name
- NCT02286544
- Testing
- Salmonella typhi vaccine (Typhim Vi®), Oxygen (Oxymask®), Atorvastatin
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Acute Myocardial Infarction, STEMI
Delivery SSO2 Therapy for 60 Min in Anterior MI Patients With PCI ≤ 6 Hours of Symptoms Onset Compared to Standard.
A multi-center randomized post-approval evaluation of delivery of intracoronary hyperoxemic supersaturated Oxygen therapy for 60 minutes in anterior AMI patients with successful reperfusion (via PCI) within 6 hours after onset of…
- Trial name
- NCT04743245
- Testing
- TherOx DownStream System, PCI
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- TherOx
Heart Failure, Myocardial Infarction
Incidence of and Prognostic Factors Associated With Heart Failure Following Myocardial Infarction: a CALIBER Study
The main objectives of this study are: i) to investigate the incidence and prevalence of fatal and non-fatal heart failure (HF) following myocardial infarction (MI) and its evolution over time in men and in women; ii) to identify…
- Trial name
- iHF (NCT02384213)
- Where
- United Kingdom
- Volunteers
- 55,000 people, healthy volunteers welcome
- Sponsor
- University College, London