Clinical trials: Heart and Blood Disease
Anticoagulation, Atrial Fibrillation
AntiCoagulation Tracking InterVention and Evaluation
Anticoagulants are a leading cause of acute injury from adverse drug events, leading to ~20,000 serious injuries reported to the Food and Drug Administration per year and more than 220,000 emergency department visits annually.
- Conditions
- Anticoagulation, Atrial Fibrillation, Atrial Flutter, Pulmonary Embolus/Emboli
- Trial name
- ACTIVE (NCT04059965)
- Testing
- Panel Management for Anticoagulation Therapy, Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Coronary Artery Spasm, Hypertension
The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering…
- Trial name
- NCT01882790
- Where
- 3 sites in South Korea
- Volunteers
- 1,933 people
- Sponsor
- Korea University
Acute Coronary Syndrome, Chronic Coronary Syndrome
A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc.
- Trial name
- NCT06955143
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Physiological Monitoring, Critically Ill
Comparative in Patient, Non-intervention Study of the Remote Physiological Monitoring System (RPM™) vs Standard Physiological Monitoring Devices
The Remote Physiological Monitoring System (RPM™) is a wireless technology for physiological monitoring. The RPM™ is designed to capture, transmit and remotely monitor the vital signs of a patient or group of patients.
- Trial name
- NCT00664924
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Heart Failure, Congestive
Ursodeoxycholic Acid in Chronic Heart Failure
This is a double-blind, placebo-controlled, cross-over study evaluating the effects of UDCA on peripheral blood flow and immune function in patients with stable chronic heart failure (CHF).
- Trial name
- NCT00285597
- Testing
- Ursodeoxycholic Acid
- Where
- United Kingdom
- Sponsor
- National Heart and Lung Institute
Essential Hypertension, High Blood Pressure
Intensive Vasodilator Therapy in Patients With Essential Hypertension
The purpose of this study is to determine whether add-on of intensive vasodilator therapy can improve the coronary perfusion and reduce the total peripheral resistance in patients with ongoing treatment for essential hypertension.
- Trial name
- Vasomore (NCT01180413)
- Testing
- Amlodipine, Ramipril, Lercanidipine
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Aarhus University Hospital
Thalassemia
T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients
The purpose of this study is to provide accurate prognostic data linking cardiac complications to myocardial T2* values (A measure of iron levels in the heart using MRI)in patients predisposed to heart iron overload.
- Trial name
- NCT00520559
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Hot Flashes, Heart Rate
Influence of Nebivolol on Postmenopausal Women
After menopause the coronary artery disease (CAD) risk increases rapidly to an equivalent risk of men with the same age. The rising incidence of CAD could be a subsequent decline of endogenous estrogen blood levels after the…
- Conditions
- Hot Flashes, Heart Rate, Blood Pressure, Endostatin
- Trial name
- NCT01161823
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Infective Endocarditis (IE), Severe Anemia
Anemia Therapy in Patients With Infective Endocarditis
Infective endocarditis (IE) is a bacterial infection of the heart valves, inserted material or surrounding struc-tures and is associated with a high morbidity and mortality.
- Trial name
- POET-IRON (NCT07523646)
- Testing
- Adjunctive anemia therapy
- Where
- Denmark
- Volunteers
- 74 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Anemia, Iron Deficiency
Effects of Ferinject® on Anemia and Transfusion Rates After Cardiac Surgery
Several studies using new forms of intravenous iron showed that it is effective in treating perioperative anemia in orthopedic and digestive surgery.
- Trial name
- FCAACS (NCT03759964)
- Testing
- Ferric carboxymaltose
- Where
- Lebanon
- Volunteers
- 194 people
- Sponsor
- St Joseph University, Beirut, Lebanon
Acute Coronary Syndrom, Chronic Obstructive Pulmonary Syndrom
Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen
In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD).
- Trial name
- PAPA (NCT02587481)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Heart Diseases, Acquired Immunodeficiency Syndrome
AIDS-Associated Heart Disease -- Incidence and Etiology
To detect by Doppler echocardiography the incidence of cardiac abnormalities in HIV-positive patients in a prospective, longitudinal study.
- Conditions
- Heart Diseases, Acquired Immunodeficiency Syndrome, Myocardial Diseases, HIV Infections
- Trial name
- NCT00005228
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome
Platelets Count Alterations in Patients With Acute Coronary Syndrome
Platelet count alterations (thrombocytopenia and thrombocytosis) are a common condition in patients hospitalised for acute coronary syndrome (ACS), both at disease onset and in the following recovery phase.1-3 Different factors…
- Trial name
- NCT03583411
- Testing
- Epidemiological data collection
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Niguarda Hospital
Anemia, Aortic Stenosis
Erythropoietin + Iron Therapy for Anemic Patients Undergoing Aortic Valve Replacement
The objective of the study is to evaluate the efficacy of Erythropoietin (EPO) (+ iron) in reducing the rate of red blood cell transfusion requirements in patients with aortic stenosis undergoing transcatheter aortic valve…
- Trial name
- EPICURE (NCT02390102)
- Testing
- Erythropoietin
- Where
- Canada
- Volunteers
- 117 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Spinal Cord Injury
Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury.
- Trial name
- NCT06691165
- Testing
- Low oxygen therapy (LOT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Glen Foster
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Atrial Fibrillation, Acute Coronary Syndrome
Antithrombotic Triple Therapy in Humans
Background:The acute coronary syndrome (ACS) is a complication of coronary artery disease (CAD) and associated with increased mortality.
- Trial name
- NCT01812200
- Testing
- Dabigatran, Ticagrelor, ASA, Rivaroxaban, Ticagrelor, ASA, Phenprocoumon, Ticagrelor, ASA
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiovascular Diseases, Heart Diseases
Adolescent Blood Pressure Variation and Ventricular Mass
To evaluate possible early neurogenic influence in essential hypertension by monitoring heart growth in adolescents over a two year interval.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005200
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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