Clinical trials: Heat Effect
Hyperthermia, Thermoregulation
Enhancing Heat Resiliency in Older Adults During Indoor Overheating Via Heat Acclimation by Warm Water Immersion
As overheating in buildings is expected to increase as global warming continues, proactive measures to increase heat resiliency in heat-vulnerable older people are needed, especially for those without access to home cooling or…
- Conditions
- Hyperthermia, Thermoregulation, Aging, Heat Acclimation and Thermotolerance
- Trial name
- NCT06670365
- Testing
- Heat acclimation by warm-water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Muscle Force, Hyperthermia
Dopamine and Muscle Function in the Heat
our goal is to study the effects of dopamine activity, using Ritalin ingestion, on neuromuscular function over the course of a progressive heating and cooling protocol developed in our lab.
- Trial name
- NCT03515668
- Testing
- Ritalin 20 mg Tablet
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brock University
Healthy Subjects/Volunteers
Effects of Combined Heat Application and Acupressure to the Carotid Artery Region on Cerebral Blood Flow in Healthy Adults
The aim of this study is to investigate the effects of combined heat application and acupressure to the carotid artery region on cerebral blood flow in healthy adults
- Trial name
- NCT07324226
- Testing
- Combined heat and acupressure
- Where
- South Korea
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Diarrhea, Infantile
Human Challenge Model With ST-only Enterotoxigenic Escherichia Coli
Heat stable toxin (ST) producing ETEC strains are important causes of childhood diarrhea in many countries. Vaccine candidates targeting ST are in development.
- Trial name
- ETECvacWP2 (NCT02870751)
- Testing
- TW11681 or TW10722
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Diabetes, Heat
Transcutaneous Electrical Stimulation and Controlled Heat in People With and Without Diabetes
The investigators would like to see if the combination of TENS and controlled heat in a boot increases blood flow to the foot more than baseline or heat alone in people with and without diabetes.
- Conditions
- Diabetes, Heat, Perfusion; Complications
- Trial name
- TENS (NCT07063524)
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western Michigan University
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Healthy
Anesthetics and Auditory, Visceral, and Heat Evoked Potentials
The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.
- Trial name
- NCT00534586
- Testing
- Propofol, Remifentanil, S-Ketamine
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Pain, Hyperalgesia
Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models
MOR-NRI like Tapentadol are expected to reduce signs and symptoms of central sensitisation besides effectively reducing pain intensity in pain.
- Conditions
- Pain, Hyperalgesia, Allodynia
- Trial name
- NCT01615510
- Testing
- Tapentadol immediate release
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Establishing Normative Values of Cold and Contact Heat-evoked Potentials
Clinical Use of Cold and Contact Heat-evoked Potentials: Normative Values
This prospective interventional study aims at recording contact heat evoked potentials (CHEPs) and cold evoked potentials (CEPs) in a healthy population sample in an aim to derive normative values which could be used to evaluate…
- Trial name
- NCT05699317
- Testing
- Thermal stimuli
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Hyperthermia
Cold Water Immersion Stirring in Hyperthermic Individuals
The best way to cool a very hot person is using cold water immersion, however, the optimization of this technique has not been established.
- Trial name
- NCT04613843
- Testing
- Water Stirring, No Water Stirring
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Heat Stress, Physiological Stress
Physiological Strain in Young Adults During a Simulated Heat Wave
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events.
- Trial name
- NCT06618352
- Testing
- Simulated indoor overheating exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Hyperthermia
Semiconductor Heat Extraction Cooling
Heat-related injuries and other physiological stresses continue to be a significant threat to the health and operational effectiveness of the US Armed Forces (Armed Forces Health Surveillance 2011).
- Trial name
- SHE-Cool (NCT04915859)
- Testing
- Hand Cooling at 12-15 degrees celsius, Hand Cooling at 16-20 degrees celsius, hand and back cooling at 12-15 or 16-20 degrees celsius
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Heat Acclimation and Thermotolerance
Chronic Exercise With Overdressing
The purpose of this study is to determine if five training sessions of exercise with overdressing can induce heat acclimation.
- Trial name
- Chronic-XO (NCT07099872)
- Testing
- Control, Overdressing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Effect of Superstarch on Soccer Performance
Superstarch and Physical/Cognitive Performance Following a Simulated Soccer Game
To assess the efficacy of a hydrothermally modified starch supplement (Superstarch made byGeneration UCAN) vs isoenergetic placebo (glucose) on exercise performance, execution of specific soccer skills, and on cognitive function…
- Trial name
- NCT02667340
- Testing
- Superstarch
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Heat Stroke, Healthy
The Development Of A Novel Biomarker For Early Identification Of The Individual's State Of Tolerance To Heat
Today, the level of tolerance to heat is based on physiological strain indices, with no correlates to any relevant biomarker. We hypothesize that oxidative stress (OS) and the formation of reactive oxygen and nitrogen species…
- Trial name
- NCT01290159
- Testing
- heat tolerance test (HTT)
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Heat Illness, Quality of Life
Structural Heat Adaptation and Education in Rural Setting
This study aims to understand whether simple, low-cost interventions, such as improved home cooling, practical advice, and minor home modifications, can help protect people's health and quality of life during periods of extreme…
- Trial name
- SHAPES (NCT06983483)
- Testing
- Community education and awareness, Participatory local structural and environmental heat mitigation solutions
- Where
- Pakistan
- Volunteers
- 7,128 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Neck Pain
Effects of Neck Stabilization Exercise With Heat Therapies
In this study, we aimed to determine the effects of heat therapies and neck stabilization exercises on pain, disability, range of motion, and mood of NP patients.
- Trial name
- NCT05771441
- Testing
- neck stabilization exercise (nse), NSE + HOT PACK THERAPY, NSE + infrared therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hilal Yeşil
Obesity, Type 2 Diabetes Mellitus
The Heat Study: 2 Year Lifestyle Intervention in Overweight Women to Encourage Weight Management
The purpose of this trial is to determine the most cost effective programme for overweight and obese individuals to maintain weight loss over a 2 year period.
- Trial name
- NCT00128336
- Testing
- Lifestyle: diet and exercise intervention
- Where
- New Zealand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Otago
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Pain, Anxiety
Impact of Passive VR Versus Active VR on Heat Pain Thresholds and Pressure Pain Thresholds
This is a prospective, crossover study of healthy participants evaluating the impact of passive vs. active virtual reality (VR) games on heat pain threshold (HPT) and pressure pain threshold (PPT).
- Trial name
- NCT05836649
- Testing
- Oculus Go headset without active intervention, Oculus Go headset with active intervention, Oculus Go headset without immersive virtual reality experience
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Stanford University