Clinical trials: Helicobacter
Probiotic, Gut Microbiota
The Effects of Yogurt on Gut Microbiome and Metabolism in H. Pylori.
Helicobacter pylori is a common pathogen causing upper gastrointestinal diseases including gastric ulcer and gastric cancer. Recent epidemiological findings have also shown that it is also related to colon cancer, metabolic…
- Conditions
- Probiotic, Gut Microbiota, Helicobacter Pylori Infection, Insulin Resistance
- Trial name
- NCT05374980
- Testing
- Yogurt
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Helicobacter Pylori
Association of Oral Helicobacter Pylori Infection With Gastric Helicobacter Pylori Infection
The aim of this study was to investigate the association between oral Helicobacter pylori infection and gastric Helicobacter pylori infection.
- Trial name
- NCT05790512
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Infection
The Efficacy of the Tailored Therapy Based on Antimicrobial Susceptibility for 2nd Eradication of H. Pylori
As increasing the antibiotics resistance, the effectiveness of traditional Helicobacter pylori (H. pylori) therapies has been declined coincidently. In this study, the investigators evaluated the efficacy of H.
- Trial name
- NCT02349685
- Testing
- H. pylori culture and antimicrobial susceptibility test, 14 day PBMT group, 14 day MEA group
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Helicobacter Pylori Infection, Helicobacter Pylori Eradication Antibiotic
The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change
This clinical controlled study enrolled 73 H. pylori（Helicobacter Pylori ）-infected female participants, stratified into reproductive-age and menopausal cohorts, alongside 10 non-infected controls.
- Trial name
- NCT07408271
- Testing
- rabeprazole-based triple therapy plus bismuth H. pylori eradication therapy
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Helicobacter Pylori Infection
Human Mass Balance and Biotransformation Study of [14C]TNP-2198
The purpose of the study is to analyze absorption, metabolism, excretion, mass balance and biotransformation after a single oral dose of [14C]TNP-2198 in healthy male participants
- Trial name
- NCT06137573
- Testing
- [14C]TNP-2198
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- TenNor Therapeutics (Suzhou) Limited
Helicobacter Pylori, Gastric Antrum
Value of Additional Corpus Biopsy for Diagnosis of H Pylori in Atrophic Gastritis. Prospective Non-randomized Study
There are controversies about the best sites -biopsy based -tests for H pylori associated gastritis. The study is designed to evaluate the optimal site of gastric mucosal biopsy for identification of Helicobacter pylori…
- Conditions
- Helicobacter Pylori, Gastric Antrum, CORPUS BIOPSIES
- Trial name
- NCT02675010
- Testing
- ENDOSCOPIC GASTRIC BIOPSIES FROM ANTRUM AND BODY
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Helicobacter Pylori Infection
ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION
H pylori is an important cause of chronic gastritis and other complications. There is a decline in eradication rate for H pylori owing to multiple factors including drug resistance.
- Trial name
- NCT03968302
- Testing
- ARM A Triple therapy for helicobacter pylori, ARM B Quadruple therapy for helicobacter pylori
- Where
- Pakistan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Helicobacter Pylori, Gastritis
Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults
This study was designed to investigate the safety and immunogenicity of Chiron's investigational H. pylori (HP3) vaccine
- Conditions
- Helicobacter Pylori, Gastritis, Gastric Cancer, Gastroduodenal Ulcers
- Trial name
- NCT00613665
- Testing
- helicobacter pylori vaccine
- Where
- Germany
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Gastric (Stomach) Cancer, Helicobacter Infection
An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori
This study is intended to be a prospective observational cohort study. The incidence of gastric cancer and progression of gastric precancerous lesions will be compared between groups through prospective follow-up of a population…
- Trial name
- NCT06896370
- Testing
- observational study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Helicobacter Pylori Infection, Dyspepsia
Effect of H. Pylori Eradication on The Improvement of Gastrointestinal Symptoms
This study aims to evaluate the effect of Helicobacter pylori eradication on gastrointestinal symptoms in adult patients. H. pylori infection is a common cause of dyspepsia and other upper gastrointestinal complaints.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Symptoms
- Trial name
- HPE-GI (NCT07272681)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amany Usama Ahmed Arafa
HIV, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana
The main objective of the study is to investigate the impact of H. pylori infection on immune activation and clinical outcome in HIV patients. Other specific study objectives are: 1. To investigate the effects of H.
- Trial name
- HHECO (NCT01897909)
- Where
- Ghana
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Gastric Atrophy, Gastric Cancer
Epidemiology of Helicobacter Pylori Infection in Moscow
H. pylori is transmitted from individual to individual and causes chronic active gastritis in all infected people. H. pylori infection can result in gastroduodenal ulcers, atrophic gastritis (AG), gastric carcinoma, and gastric…
- Conditions
- Gastric Atrophy, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT05775120
- Testing
- OLGA and H.pylori culture
- Where
- Russia
- Volunteers
- 5,121 people, healthy volunteers welcome
- Sponsor
- Moscow Clinical Scientific Center
Healthy
To Investigate Pharmacokinetics and Pharmacodynamics of CJ-12420 After Single and Multiple Dose Administration
The purpose of this study is to compare the pharmacokinetics and pharmacodynamics of CJ-12420 after single and multiple dose administration according to H. pylori infection.
- Trial name
- NCT03009760
- Testing
- CJ-12420 50mg(HP-), CJ-12420 100mg(HP-), CJ-12420 50mg(HP+)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Erosive Esophagitis, Heartburn
A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily
The primary objective is to determine the pharmacokinetics (PK) of vonoprazan in breast milk of healthy lactating women who have received vonoprazan administered once daily or vonoprazan 20 mg administered twice daily for 4…
- Conditions
- Erosive Esophagitis, Heartburn, Symptomatic Nonerosive Gasroesophageal Reflux Disease, Helicobacter Pylori Infection
- Trial name
- NCT06391177
- Testing
- Vonoprazan
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Phathom Pharmaceuticals, Inc.
Ulcer, Blood Tests
Functional Food Product
Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H.
- Conditions
- Ulcer, Blood Tests, Liver Function Tests
- Trial name
- NCT07789561
- Testing
- pomegranate peel powder 1.5 g, pomegranate peel powder 3 g, Whole wheat muffin
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Infection, Achlorhydria
Clinical Experiment of Helicobacter Pylori Transmission
The study proposes to test whether chronic infection with Helicobacter pylori protects individuals from symptomatic infection with enteropathogenic E. coli.
- Trial name
- NCT00550368
- Testing
- Biological intervention: Enteropathogenic E. coli
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Helicobacter Pylori Infection, Antibiotic Resistant Infection
Optimal Tailored Treatment for H. Pylori Infection
The efficacy of the current standard triple therapy is at an unacceptably low level. Resistance to antibiotics is suspected to be the major cause of the low efficacy of standard triple therapy.
- Trial name
- NCT04462133
- Testing
- Dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR)
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Heliobacter Pylori Infection
Effect of Helicobacter Pylori on the Availability of Vitamin E and C
This study argues that H.pylori infection, by increasing the production of reactive oxygen species, increases the utilization of dietary antioxidants(Vit E and Vit C) that serve in quenching the free radicals, thus decreasing…
- Trial name
- NCT00303160
- Testing
- vitamin C & E supplements
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Gastric Xanthoma, Helicobacter Pylori Infection
A Study on the Relationship Between Gastric Xanthoma and Gastric Cancer and Precancerous Lesions
To explore the effects of gastric xanthoma on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Gastric Xanthoma, Helicobacter Pylori Infection, Gastric Cancer, Intestinal Metaplasia
- Trial name
- NCT06282484
- Where
- China
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Helicobacter Pylori Infection
Helicobacter Pylori Infection Occurrence in Russia
This study is planned to reveal the occurrence rate of H.pylori infection in ambulatory settings' patients in Russia and to compare the occurrence rates in different years in treatment-naïve and previously treated subjects.
- Trial name
- NCT04892238
- Testing
- 13-C urea breath test
- Where
- 2 sites in Russia
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution