Clinical trials: Helicobacter Pylori Resistance
Peptic Ulcer
The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients
This study assessed the effect of tailored eradication therapy according to Clarithromycin resistance in Helicobacter pylori patients.
- Trial name
- NCT02648659
- Testing
- Ilaprazole, Amoxicillin, Clarithromycin
- Volunteers
- 50 people
- Sponsor
- Kyungpook National University Hospital
Helicobacter Pylori Infection
High Dose Dual Therapy vs Clarithromycin Triple Therapy for Treatment Naive H Pylori Infection in an Urban Population
A phase 4 prospective, randomized, open-label clinical trial evaluating the efficacy of high dose dual therapy vs standard triple therapy in a diverse, urban New York City population.
- Trial name
- NCT05342532
- Testing
- Amoxicillin, Omeprazole, Clarithromycin
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Helicobacter Pylori Infection
Molecular Detection of Antibiotic Resistance and H Pylori Eradication
H pylori eradication failure with recommended triple therapy is mainly related to antibiotic resistance. However,IN VITRO culture of H pylori is uneasy and is not performed in routine practice.
- Trial name
- HELICOSTIC (NCT01168063)
- Testing
- Molecular detection of antibiotic resistance, standard triple therapy (PPI, amoxicillin, clarithromycin, metronidazole)
- Where
- France
- Volunteers
- 1,386 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori Infection, Compliance, Patient
Comparison of Bismuth Containing Quadruple Therapy and Based Tailored Therapy for H. Pylori Infection
As the antibiotic resistance increases, the eradication rate of triple therapy is decreasing. Recent guideline recommend the use of bismuth-containing quadruple therapy in areas where clarithromycin resistance is greater than…
- Conditions
- Helicobacter Pylori Infection, Compliance, Patient, Drug Resistance, Antibiotics
- Trial name
- NCT03361267
- Testing
- Helicobacter pylori PCR test, CLO test
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Inha University Hospital
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
H. Pylori Infection and Metabolic Syndrome: A Retrospective Cross-Sectional Study
This retrospective cross-sectional study evaluates the association between Helicobacter pylori infection and metabolic syndrome using health examination data from 5,218 adults at Nanjing First Hospital.
- Trial name
- NCT07651202
- Testing
- No intervention. This is an observational study.
- Where
- China
- Volunteers
- 5,218 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Duodenal Ulcer, Helicobacter Pylori Infection
Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection
The aims of this study are (1) to evaluate the prevalence rate of PM of CYP2C19 in our country; (2) to evaluate the efficacy of dual therapy with different dose of omeprazole and amoxicillin; (3) to judge the relationship of…
- Trial name
- NCT00854451
- Testing
- omeprazole plus amoxicillin
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Susceptibility-Guided Sequential Therapy for Helicobacter Pylori Infection
The main objective of this trial is to assess whether a sequential therapy strategy based on molecular antibiotic susceptibility testing (including clarithromycin and fluoroquinolone) for H.
- Trial name
- NCT05549115
- Testing
- clarithromycin-sensitive(first-line), clarithromycin-resistant(first-line), empirical therapy group first-line
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Liaocheng People's Hospital
Helicobacter Pylori
Study of the Esophageal String Test (EST) for the Diagnosis of Helicobacter Pylori
Background: Helicobacter pylori is a bacterium that infects the lining of the stomach and intestines. It can cause peptic ulcers, cancers, and infections. Current methods of diagnosing H. pylori infections have limitations.
- Trial name
- NCT06871579
- Testing
- EnteroTracker(R) EST
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fatty Liver, Liver Dysfunction
The Effect of Helicobacter Pylori Eradication on Liver Fat Content in Non-alcoholic Fatty Liver Disease
The role of Helicobacter pylori(HP)in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) is controversial.
- Conditions
- Fatty Liver, Liver Dysfunction, Insulin Resistance
- Trial name
- NCT01876108
- Testing
- H.pylori eradication (Omeprazole, Amoxicillin, Bismuth subcitrate, Azithromycin)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Self Efficacy
Genotypic Resistance Guided Therapy in Helicobacter Pylori Eradication
We aimed to compare the efficacy of genotypic resistance guided sequential therapy vs. empiric therapy in the third line therapy.
- Trial name
- NCT01725906
- Testing
- empirical therapy, Genotypic resistance guided therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection, Resistant Infection
One Sequencing Find All for Helicobacter Pylori Infection
The aim of this study is to Identify antibiotic resistance gene mutations in Helicobacter pylori (HP) and genetic diversity of drug metabolism for antibiotics and proton pump inhibitors (PPIs) in patients with HP infection using…
- Trial name
- NCT03837990
- Testing
- Helicobacter Pylori eradication therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Dyspepsia
Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital
Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide.
- Trial name
- NCT00285688
- Testing
- gastroscopic examination
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Helicobacter Pylori, Drug Resistance, Multiple
14-day Susceptibility-guided Bismuth Quadruple Therapy for Multiple Drug Resistant H. Pylori Infection
The goal of this clinical trial is to learn if the 14-day susceptibility-guided bismuth quadruple therapy works to treat multiple drug resistant Helicobacter pylori (H. pylori) in adults.
- Trial name
- BSUS-2 (NCT06687499)
- Testing
- Bismuth-based susceptibility-guided treatment
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- National Cheng-Kung University Hospital
Probiotic, Gut Microbiota
The Effects of Yogurt on Gut Microbiome and Metabolism in H. Pylori.
Helicobacter pylori is a common pathogen causing upper gastrointestinal diseases including gastric ulcer and gastric cancer. Recent epidemiological findings have also shown that it is also related to colon cancer, metabolic…
- Conditions
- Probiotic, Gut Microbiota, Helicobacter Pylori Infection, Insulin Resistance
- Trial name
- NCT05374980
- Testing
- Yogurt
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Non-alcoholic Fatty Liver Disease
Helicobacter Pylori Eradication in Non-diabetic Non-alcoholic Steatohepatitis
The aim of study was to evaluate the effect of helicobacter pylori eradication on liver fat content, liver function tests, lipid profile, homeostasis model assessment-IR (HOMA-IR) index, and anthropometric measurements (body mass…
- Trial name
- NCT01654549
- Testing
- H.pylori eradication
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Helicobacter Infections
Efficacy and Safety of Quadruple Therapy in Eradication of H. Pylori: A Comparison to Triple Therapy
This study aims at evaluating efficacy and safety of quadruple therapy (bismuth, metronidazole, tetracycline and omeprazole: OBMT) vs triple therapy (amoxicillin, clarithromycin and omeprazole: OAC) in H. Pylori eradication.
- Trial name
- NCT00669955
- Testing
- Omeprazole, amoxicillin, clarithromycin, Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole
- Where
- United Kingdom
- Volunteers
- 440 people
- Sponsor
- Forest Laboratories
H. Pylori Infection
H. Pylori Treatment Between Modified Quadruple Regimen and Tailored Therapy
The rate of H. pylori resistance to antimicrobial agents including clarithromycin (CAM) has increased worldwide. Eradication failure using triple therapy is strongly associated with CAM-resistant H. pylori.
- Trial name
- NCT05002595
- Testing
- H. pylori eradication
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Soonchunhyang University Hospital
H.Pylori Infection, H.Pylori Gastrointestinal Disease
Concomitant Versus Hybrid Regimen for H. Pylori Eradication
10 day concomitant versus 14 day hybrid regimen as first line H. pylori eradication treatment in a high clarithromycin resistance area. A multicenter, randomized, equivalence trial.
- Conditions
- H.Pylori Infection, H.Pylori Gastrointestinal Disease, H. Pylori Associated Phlegmonous Gastritis
- Trial name
- NCT03592069
- Testing
- 10 day concomitant regimen, 14 day hybrid regimen
- Where
- Greece
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
H Pylori Infection
Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection
The inviestigators aimed to compare the efficacy of genotypic resistance guided versus susceptibility testing guided therapy in the third line treatment for refractory H. pylori infection.
- Trial name
- NCT03555526
- Testing
- Esomeprazole 40mg, Amoxicillin, metronidazole
- Where
- Taiwan
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Helicobacter Pylori Infection
Rabeprazole Based Sequential-Concommitant Hybrid Therapies for H. Pylori Infections
This prospective controlled randomized open-label clinical trial is designed to determine the optimal eradication rate of rabeprazole based sequential-concommitant hybrid therapies for adults infected with Helicobacter pylori in…
- Trial name
- NCT01566643
- Testing
- RA5-RACM7, RA3-RACM7, RA7-RACM7
- Where
- Taiwan
- Volunteers
- 231 people
- Sponsor
- Buddhist Tzu Chi General Hospital