Clinical trials: Hematologic
Anemia, Hemosiderosis
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia Patients
A 1-year randomized Phase II core trial was conducted to investigate the efficacy of deferasirox in regularly transfused patients with β-thalassemia and other rare chronic anemia 2 years of age and older.
- Trial name
- NCT00303329
- Testing
- Deferasirox
- Where
- 28 sites in United States, Belgium and 5 more
- Volunteers
- 184 people
- Sponsor
- Novartis Pharmaceuticals
Leukemia, Lymphoma
Planned Donor Lymphocyte Infusion (DLI) After Allogeneic Stem Cell Transplantation (SCT)
The goal of this clinical research study is to learn what dose of a kind of immune cell called T-lymphocytes (T-cells) given as a donor infusion about 8-9 weeks after a stem cell transplant has the best results.
- Conditions
- Leukemia, Lymphoma, Myeloma, Myeloproliferative Diseases
- Trial name
- NCT01518153
- Testing
- Fludarabine, Melphalan, Alemtuzumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Hepatitis C
Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3
This study will examine the effectiveness of low-dose peginterferon and ribavirin therapy for certain patients with chronic hepatitis C-a liver disease that, in some patients, can progress to cirrhosis of the liver, liver cancer…
- Trial name
- NCT00056862
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cancer, Oncology
Seen and Be Heard: Ensuring Fair Cancer Care for All Children
Introduction: Research has routinely been conducted into the experiences and well-being of children and young people with cancer and their families.
- Conditions
- Cancer, Oncology, Haematological Malignancy
- Trial name
- NCT06481527
- Volunteers
- 50 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Myelofibrosis
Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor
The purpose of this study is to evaluate the efficacy and safety of 2 dose regimens of imetelstat in participants with intermediate-2 or high-risk myelofibrosis (MF) whose disease is relapsed after or is refractory to Janus…
- Trial name
- NCT02426086
- Testing
- Imetelstat 4.7 mg/kg, Imetelstat 9.4 mg/kg
- Where
- 72 sites in United States, Belgium and 9 more
- Volunteers
- 107 people
- Sponsor
- Geron Corporation
Chronic Lymphocytic Leukemia
A Study of AZD6738 and Acalabrutinib in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
This study evaluates the safety, pharmacokinetics, pharmacodynamics and efficacy of acalabrutinib and ceralasertib (known as AZD6738) when taken in combination.
- Trial name
- NCT03328273
- Testing
- Ceralasertib, Acalabrutinib
- Where
- 11 sites in Poland, United Kingdom
- Volunteers
- 12 people
- Sponsor
- Acerta Pharma BV
Lymphocytic Leukemia, Mantle Cell Lymphoma
Lenalidomide in Comb w/Rituximab for Pts w/CD5+/CD20+ Hem Malignancies Who Relapse/Progress After Rituximab
The purpose of this research is to evaluate the use of Rituximab in combination with Revlimid in the treatment of refractory Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL).
- Trial name
- NCT00609869
- Testing
- Lenalidomide, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Virtual Reality Experiences for Anxiety and Pain Control
This trial studies the impact of virtual reality experiences on anxiety before surgery and pain after surgery. The goal of this study is to examine how different virtual reality experiences may help reduce anxiety and improve…
- Trial name
- NCT04759183
- Testing
- Survey Administration, Virtual Reality Game, Virtual Reality Meditation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Anemia, Iron-Deficiency, Colorectal Cancer
Efficacy of Preoperative Intravenous Iron in Anaemic Colorectal Cancer Surgical Patients
Iron deficiency anaemia is a common condition among colorectal surgical patient. Untreated anaemia would lead to increase in blood transfusion, surgical complications and mortality.
- Trial name
- NCT03565354
- Testing
- iron isomaltoside(Monofer®)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Allograft, Post-allograft Relapse
RElapse After Allograft: Link Between LoCus of Control and QualiTy of Life
Allogeneic hematopoietic transplantation (AlloHCT) is a robust therapeutic that is used as a consolidation strategy in a number of haematological cancers. It provides durable responses as compared to chemotherapy alone.
- Trial name
- REACT (NCT05258929)
- Testing
- Data collection (Prior and planned treatments, allograft)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Multiple Myeloma
Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma
The outcomes in patients with relapsed or refractory multiple myeloma refractory to triple-therapy remain poor. These patients are eligible for chimeric antigen receptor T-cells (CAR-T), which rely on redirecting autologous…
- Trial name
- NCT07200102
- Testing
- Selinexor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Acute Myeloid Leukaemia (AML), Hematopoietic Stem Cell Transplant (HSCT)
Safety and Efficacy of FT14 Conditioning for Allogeneic HSCT in Acute Myeloid Leukemia
This is a prospective, multicenter, phase II, open-label, non-randomized clinical trial designed to evaluate the safety and efficacy of the Fludarabine plus Treosulfan 14 g/m² (FT14) conditioning regimen for allogeneic stem cell…
- Trial name
- FT14 (NCT07232953)
- Testing
- Fludarabine + Treosulfan
- Where
- 13 sites in Italy
- Volunteers
- 82 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Malaria, Schistosomiasis
Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana
The purpose of this study is to determine if Artemisinin-based Combination Therapy, ACT,(artemether-lumefantrine) used as intermittent preventive treatment (IPT) alone or in combination with praziquantel, will have any effects on…
- Conditions
- Malaria, Schistosomiasis, Helminthiasis, Anemia
- Trial name
- ACTIPT (NCT01459146)
- Testing
- Artemether-lumefantrine combination plus albendazole, Artemether-lumefantrine plus Praziquantel plus Albendazole, Albendazole plus Praziquantel
- Where
- Ghana
- Volunteers
- 345 people
- Sponsor
- Navrongo Health Research Centre, Ghana
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
An Efficacy and Safety Study of Azacitidine Subcutaneous in Combination With Durvalumab (MEDI4736) in Previously Untreated Adults With Higher-Risk Myelodysplastic Syndromes (MDS) or in Elderly Patients With Acute Myeloid Leukemia (AML)
The primary objective of this study is to evaluate the efficacy of subcutaneous azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in adults with previously untreated, higher risk MDS who…
- Trial name
- NCT02775903
- Testing
- Azacitidine, Durvalumab
- Where
- 103 sites in United States, Austria and 10 more
- Volunteers
- 213 people
- Sponsor
- Celgene
Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes
Treatment of MDS/AML Patients With an Impending Hematological Relapse With AZA or ATA and Pevonedistat
MDS/AML with MRD and impending relapse after allogeneic stem cell transplantation and/or conventional chemotherapy
- Conditions
- Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Minimal Residual Disease
- Trial name
- NCT04712942
- Testing
- Pevonedistat, Azacitidine
- Where
- 14 sites in Germany
- Volunteers
- 14 people
- Sponsor
- University of Leipzig
Cardiopulmonary Arrest, Pediatric ALL
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
The International Liaison Committee on Resuscitation regularly publishes a Consensus on Science with Treatment Recommendations but guidelines can nevertheless differ when knowledge gaps persist.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- NCT05474170
- Testing
- AHA resuscitation sequence, ERC resuscitation sequence
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Acute Promyelocytic Leukemia
Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia
Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q24;21) and the fusion gene PML-RARA. We have formulated an oral preparation of As2O3 (oral-As2O3), and shown that it is efficacious for APL in R1, inducing CR2 in…
- Trial name
- NCT03624270
- Testing
- Oral arsenic Trioxide, ATRA and ascorbic acid
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A study of acalabrutinib plus venetoclax (AV) versus venetoclax plus obinutuzumab (VO) in previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
- Trial name
- MAJIC (NCT05057494)
- Testing
- Acalabrutinib, Venetoclax, Obinutuzumab
- Where
- 37 sites in United States, Australia and 5 more
- Volunteers
- 607 people
- Sponsor
- AstraZeneca
Ehlers-Danlos Syndrome, Fibromuscular Dysplasia
Study of Arterial Properties by Ultra-high Frequency Ultrasound in Fibromuscular Dysplasia and Vascular Ehlers-Danlos Syndrome
Ultra-high frequency ultrasound may be useful in the field of vascular research, given its ability to accurately characterize arterial wall thickness and ultrastructure.
- Trial name
- FUCHSIA-FR (NCT03596437)
- Testing
- Ultra High Frequency ultrasound system
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatologic Disease, Pediatric ALL
Turkish Cultural Adaptation, Validity and Reliability of the "Gait Outcomes Assessment List"
The ultimate goal of treating children with lower extremity differences is to improve quality of life, optimize function, and maximize participation by addressing the physical, social, and psychological effects of lower extremity…
- Conditions
- Rheumatologic Disease, Pediatric ALL, Children, Only, Lower Extremity Problem
- Trial name
- NCT05846672
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
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