Clinical trials: Hematological Patients
Aggressive Systemic Mastocytosis, Mast Cell Leukemia
Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia
This pilot clinical trial studies brentuximab vedotin in treating patients with advanced systemic mastocytosis or mast cell leukemia. Monoclonal antibodies, such as brentuximab vedotin, can block cancer growth in different ways.
- Conditions
- Aggressive Systemic Mastocytosis, Mast Cell Leukemia, Systemic Mastocytosis
- Trial name
- NCT01807598
- Testing
- Brentuximab vedotin
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Jason Robert Gotlib
Metastatic Cancer, Cancer Recurrence
Parental Support Intervention in an Advanced Oncological Context
This prospective, two-arm randomized trial compares a psycho-educational program to a psycho-educational and experiential program for parents with advanced cancer.
- Conditions
- Metastatic Cancer, Cancer Recurrence, Hematological Cancer, Parent-Child Relations
- Trial name
- NCT07341815
- Testing
- Psycho-Education, Psycho-Experiential
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Université Libre de Bruxelles
Breast Cancer, Gingivitis
Assessment of Periodontal Therapy and Biofilm Management in Breast Cancer
Objective: To evaluate the impact of chemotherapy on periodontal conditions, hematology, and salivary flow in patients with breast cancer and gingivitis, after basic periodontal therapy (BPT).
- Conditions
- Breast Cancer, Gingivitis, Periodontal
- Trial name
- BREASTCANCER (NCT06212908)
- Testing
- Basic Periodontal Therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Respiratory Tract Infections, Hematologic Diseases
Rapid Analysis of Infections by Spectrometry of Exhaled Breath
To quantify the diagnostic, prognostic and therapeutic value of spectrometric analysis of exhaled breath from hematological patients with respiratory infection.
- Trial name
- RAISE (NCT03299608)
- Testing
- Breath analysis
- Where
- Belgium
- Volunteers
- 246 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Advanced Malignant Neoplasm, Acute Myeloid Leukemia
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia
In this trial, ziftomenib, a menin-MLL(KMT2A) inhibitor, will be tested in patients for the first time. The trial includes a Main Study and four sub-studies.
- Conditions
- Advanced Malignant Neoplasm, Acute Myeloid Leukemia, Mixed Lineage Leukemia, Mixed Lineage Acute Leukemia
- Trial name
- NCT04067336
- Testing
- Ziftomenib, Midazolam, Itraconazole
- Where
- 43 sites in United States, Belgium and 5 more
- Volunteers
- 263 people
- Sponsor
- Kura Oncology, Inc.
Catheter-Related Infections
ATAPAC Study (TauroLock Activity in Adult Cancer Patients)
The purpose of this study is to compare the efficacy of a lock taurolidine-citrate solution vs standard saline solution for primary prevention of central venous catheter-associated bloodstream infection in adult patients treated…
- Trial name
- ATAPAC (NCT02279121)
- Testing
- Taurolock, saline solution
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Systemic Lupus Erythematosus (SLE)
Hematological Manifestations in Systemic Lupus Erythematosus Patients
The goal of this observational study is to evaluate hematological abnormalities among patients with systemic lupus erythematosus (SLE) admitted to a tertiary care center in Nepal.
- Trial name
- NCT06936007
- Where
- Nepal
- Volunteers
- 99 people
- Sponsor
- Patan Academy of Health Sciences
Hematological Cancer
Evaluation of the Impact of Sports-inspired Onco-coaching on Health-related Quality's Life of the Patients in Cancer Remission After Allogeneic Transplantation of Hematopoietic Stem Cells
To measure the impact of a coaching program on the patient's health-related quality of life 15 months post-transplant (M15/R12).
- Trial name
- NCT05486273
- Testing
- interviews with coachs, semi-structured interviews and questionnaires, semi-structured interviews and questionnaires
- Volunteers
- 108 people
- Sponsor
- Institut Paoli-Calmettes
Advanced Solid and Hematological TP53wt Tumors
Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt
To determine and evaluate a safe and tolerated dose of HDM201 in adult patients with selected advanced tumors characterized by wild-type TP53.
- Trial name
- NCT02143635
- Testing
- HDM201, ancillary treatment
- Where
- 15 sites in United States, France and 6 more
- Volunteers
- 208 people
- Sponsor
- Novartis Pharmaceuticals
Solid Tumor, Hematological Malignancies
The Good Patient Study
Adolescents with cancer weigh multiple influences in medical decision-making, including their own best interest, the perceived wishes of family members, and the interpreted preferences of the health care team.
- Conditions
- Solid Tumor, Hematological Malignancies, Brain Tumor
- Trial name
- NCT02199548
- Testing
- Interview
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- St. Jude Children's Research Hospital
Neutropenia
AMS Intervention for Early Adaptation of Empirical Antibiotic Therapy in High-risk Neutropenic Patients
Febrile neutropenia (FN) is a frequent and serious complication in patients with hematological malignancies undergoing intensive chemotherapy.
- Trial name
- NCT05793073
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Malignancies, Hematologic
Pretransplant Evaluation by Supportive Care Team for Patients Undergoing HCT for Hematological Malignancies
This is a feasibility study of pre-transplant involvement of a palliative care provider in the setting of HCT. Although this is primarily a feasibility pilot, the investigators will explore how patients are affected by the…
- Trial name
- NCT02321345
- Testing
- Palliative Care Support
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Medical College of Wisconsin
Chronic Myeloproliferative Disorders, Leukemia
Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment
RATIONALE: Giving total marrow and total lymph node irradiation together with low doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00800150
- Testing
- fludarabine phosphate, melphalan, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- City of Hope Medical Center
Invasive Aspergillosis
Clinical Implications of Azole-Resistant Aspergillosis in Hematological Malignancy
In order to determine the efficacy of antifungal therapy in patients with documented azole-resistant invasive Aspergillosis (IA), anonymized clinical information of patients with a hematological malignancy with a culture-positive…
- Trial name
- CLARITY (NCT03221075)
- Testing
- Registry
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 203 people
- Sponsor
- University Hospital of Cologne
Advanced Malignancies, Solid Tumor
Study Evaluating Food Effect and QTc in Patients With Advanced Malignancies
Phase 1 2-part study to evaluate the effect of food on pharmacokinetics of pelabresib (CPI-0610) and the effect of pelabresib on QTc in patients with advanced malignancies
- Conditions
- Advanced Malignancies, Solid Tumor, Hematological Malignancy
- Trial name
- NCT05391022
- Testing
- Pelabresib
- Where
- 10 sites in United States, Georgia and 1 more
- Volunteers
- 35 people
- Sponsor
- Constellation Pharmaceuticals
Fungal Infection
Fungal Infections in Patients With Hematological Malignancies
Report the prevalence of fungal infections among patients with hematological malignancies in South Egypt Cancer Institute. * Detect the most endemic fungal pathogen isolated from patients with hematological malignancies in South…
- Trial name
- NCT03650439
- Testing
- culture on Sabouraud's Dextrose Agar (SDA)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Leukemia, Chronic Leukemia
Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant
This is a phase 1, interventional single arm, open label, treatment study designed to evaluate the safety combination programmed cell death protein 1 (PD-1) and interleukin 6 (IL-6) inhibition in participants with relapsed…
- Conditions
- Acute Leukemia, Chronic Leukemia, Lymphoma, Myelodysplastic Syndromes
- Trial name
- NCT03588936
- Testing
- Nivolumab (.25 mg/kg), Tocilizumab, Nivolumab (.5 mg/kg)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical College of Wisconsin
Leukemia, GVHD, ATG, Transplantation
Anti-thymocyte Globulins for Graft-versus-host Disease Prophylaxis
Age is a risk factor for graft-versus-host disease (GVHD) after human leukocyte antigen (HLA)-matched sibling allogeneic stem cell transplantation (allo-SCT).
- Trial name
- NCT01856803
- Testing
- anti thymoglobulin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University People's Hospital
Oncologic Complications
Patient Intake At the 'MOvement and REhabilitation (MO.RE.)
In recent years, there has been an exponential increase in studies regarding the benefits of physical activity in oncology, with significant results on improving both physical and psychological outcomes.
- Trial name
- BACKMORE2024 (NCT06858241)
- Where
- Italy
- Volunteers
- 95 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia
Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease
This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with hematologic disease.
- Conditions
- Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Burkitt Lymphoma
- Trial name
- NCT00719888
- Testing
- Cyclophosphamide, Cyclosporine, Double-Unit Umbilical Cord Blood Transplantation
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- Fred Hutchinson Cancer Center