Clinical trials: Hemodynamic
Hemodynamic Instability
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under…
- Trial name
- NCT06268275
- Testing
- Scalp block, Esmolol
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Infant, Premature, Diseases
Measurement of Neonatal Microvascular Hemodynamics Using Non-invasive Optical Technologies
Alterations to microvascular blood flow in premature infants, are known to contribute to several major disease entities. The optically-measured tissue blood flow, to determine tissue perfusion that can be use to detect blood loss.
- Trial name
- NCT01982357
- Testing
- Laser Speckle Imaging and Diffuse Optical Spectroscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Pelvic Fractures and Associated Hemodynamic Instability
Intraoperative Angioembolization in the Management of Pelvic Fracture-Related Hemodynamic Instability
Mortality associated with pelvic fractures resulting from blunt trauma ranges between 6 and 18%. In cases where hemodynamic instability is also present, the mortality rate is significantly greater, and has been reported as high…
- Trial name
- NCT00755365
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Milton S. Hershey Medical Center
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy
Vascular Effects of Dietary Salt in Humans With Salt-Resistant Blood Pressure
The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
- Trial name
- NCT03424993
- Testing
- Dietary Sodium Restriction, Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Shock
Impact of Amount of Fluid for Circulatory Resuscitation on Renal Function in Patients in Shock
Volume resuscitation is the mainstay of treatment in most types of shock, especially in hemorrhagic and septic shock. Septic shock is a main cause of morbidity and mortality worldwide.
- Trial name
- VoluKid (NCT02666404)
- Testing
- Measurement
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University Hospital, Basel, Switzerland
Orthostatic Intolerance, Orthostatic Hypotension
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty in Patients Receiving ACEIs and ARBs
Incidence and pathophysiologic hemodynamics of postoperative orthostatic intolerance and orthostatic hypotension in patients receiving antihypertensives
- Trial name
- NCT04842058
- Testing
- Mobilisation procedure
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Hvidovre University Hospital
Intubation
Hemodynamic Response to Intubation
This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself.
- Trial name
- NCT02844894
- Testing
- Dexmedetomidine, Esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ufuk University
Left Ventricular Insufficiency
Safety Study of Chimeric Natriuretic Peptide(CD-NP) in Stable LVAD Patients
The most promising chimeric natriuretic peptide designed and studied by our group has been CD-NP which has anti-fibrotic and cardioprotective properties in vivo, vitro and in normal volunteers and human heart failure patients.
- Trial name
- NCT01750905
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Bronchoscopy, Procedural Sedation
Ciprofol Versus Propofol With Low-Dose Sufentanil for Painless Bronchoscopy
Bronchoscopy may cause coughing, discomfort, body movement, and changes in breathing or blood pressure. Propofol is commonly used for sedation during bronchoscopy, but it may cause respiratory depression, circulatory depression…
- Trial name
- NCT07744061
- Testing
- Ciprofol, Propofol, Sufentanil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wenzhou Central Hospital
Cerebral Perfusion, Cerebral Oxygenation
Evaluation of Cerebral Oxygenation During Orthopedic Surgeries Performed in the Beach Chair Position Under General Anesthesia
The goal of this observational study is to determine the correlation between cerebral oxygenation values measured by near-infrared spectroscopy (NIRS) and other routine monitoring parameters in patients placed in the semi-sitting…
- Conditions
- Cerebral Perfusion, Cerebral Oxygenation, Hemodynamic Monitoring, Semi-sitting Position
- Trial name
- NCT07270341
- Testing
- Near-Infrared Spectroscopy (NIRS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Akdeniz University
Pulse Wave Analysis
Cardiac Output Monitoring With Estimated Continuous Cardiac Output (esCCO) vs. Transpulmonary Thermodilution (TPTD)
The main goal of our study is to assess the accuracy and reproducibility of continuous beat-to-beat cardiac output (CO) measurement using pulse wave transit time in patients undergoing off-pump coronary artery bypass grafting.
- Trial name
- NCT02352324
- Testing
- Fluid responsiveness tests
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Northern State Medical University
Primary Gonarthrosis
Effects of Tourniquet Applied During Total Knee Replacement Surgery on Patient Hemodynamics and Blood Table
This study was planned to investigate the physiopathology of bradycardia and hypotension that occur in some patients with total knee arthroplasty (TKA) between the ages of 65 and 90 years when the tourniquet, which is routinely…
- Trial name
- NCT07002086
- Testing
- Total knee replacement
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Hemodynamic Variation During Surgery
Mean Systemic Pressure Measurement During Prone Position Surgery
Venous return is driven by the pressure gradient between mean systemic pressure and right atrial pressure. However, mean systemic pressure is more a physiological concept than an available clinical measurement.
- Trial name
- NCT01957605
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Hypertension on Emergence
Proseal Laryngeal Mask Airway or Endotracheal Tube for Emergence From Neuroanesthesia
Extubation and emergence from anesthesia lead to systemic and cerebral hemodynamic changes that can cause cerebral edema and hemorrhage.
- Trial name
- NCT01718470
- Testing
- Endotracheal tube, LMA
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Ricard Valero
Cardiac Surgery
Pulmonary Artery Catheters in Cardiac Surgery
The goal of this clinical trial is to learn whether avoiding a pulmonary artery catheter (PAC), a type of invasive monitoring tool, is no worse than using one in adults undergoing open heart surgery.
- Trial name
- PUMA (NCT07612683)
- Testing
- Pulmonary Artery Catheter, No Pulmonary Artery Catheter (No-PAC)
- Volunteers
- 1,600 people
- Sponsor
- Monash University
HFrEF - Heart Failure With Reduced Ejection Fraction
Impact of Barostimulation on Hemodynamics in Adults With Heart Failure
This study evaluates the effects of the implantation and adjustment of the CVRx Barostim device in adult patients with heart failure with reduced ejection fraction who are receiving maximally tolerated doses of guideline directed…
- Trial name
- BREATHE-HF (NCT07335510)
- Testing
- Baroreflex Activation Therapy
- Where
- 7 sites in United States
- Volunteers
- 58 people
- Sponsor
- Columbia University
Shock Circulatory, Cardiogenic Shock
Left Ventricular Outflow Tract Mean Velocity in Children: a Strong Alternative to Cardiac Index in Pediatric Intensive Care Unit
Objectives: Noninvasive assessment of cardiac index (CI) in pediatric critical ill patient is crucial. Aortic Velocity Time Integral (VTI) valuable in adults, faces age and heart rate variability challenges in pediatrics…
- Trial name
- NCT06837727
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Spinal Stenosis, Lumbosacral Region
Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2.
- Trial name
- TIVA (NCT06558695)
- Testing
- Sevoflurane, TIVA
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi