Clinical trials: Hemodynamic Response
Hemodynamic Responses, Laparoscopic Cholecystectomy
Hemodynamic Responses of Dexmedetomidine, Lidocaine or Propofol Infusions During Laparoscopic Cholecystectomy
This study will be carried out to compare the efficacy of dexmedetomidine, propofol or lidocaine infusions in attenuation of hemodynamic responses to pneumoperitoneum during adult laparoscopic cholecystectomy using electrical…
- Conditions
- Hemodynamic Responses, Laparoscopic Cholecystectomy, Dexmedetomidine, Lidocaine
- Trial name
- NCT05937282
- Testing
- Dexmedetomidine, Propofol, Lidocain
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Menoufia University
Lidocaine
Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that…
- Trial name
- NCT06107543
- Testing
- Nebulized Lidocaine, Iv Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Derince Training and Research Hospital
Scalp Block
Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients"
The goal of this clinical trial is to learn if an ultrasound-guided scalp block can improve intraoperative hemodynamic stability and provide better postoperative pain relief in adult patients undergoing elective supratentorial…
- Trial name
- NCT07496632
- Testing
- Surgical site infiltration with plain bupivacaine, Scalp block with plain bupivacaine
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- Bangladesh Medical University
Electroencephalography, Critical Care
Sedation Monitoring Using Frontal Electroencephalogram, Electromyogram and Hemodynamic Responses to Pain in Critical Care
Purpose: Assessing nociception and sedation in mechanically ventilated patients in the ICU is challenging, with few reliable methods available for continuous monitoring.
- Conditions
- Electroencephalography, Critical Care, Electromyography
- Trial name
- NCT04472247
- Testing
- Continuous EEG and EMG monitoring, with derived variables
- Where
- 2 sites in Finland
- Volunteers
- 30 people
- Sponsor
- University of Helsinki
Haemodynamic Rebound
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .
- Trial name
- NCT06490731
- Testing
- Dexmedetomidine, Ketamine
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- New Valley University
Craniotomy Surgery, Regional Anaesthesia
A Comparative Analysis of Combined Superficial Cervical Plexus and Supraorbital Blocks Compared to Scalp Blocks During Craniotomy: a Review of Opioid Consumption and The Suppression of Hemodynamic Responses
Perioperative pain management in craniotomy requires the administration of effective regional anesthetic techniques to reduce the use of systemic opioids and optimize hemodynamic control.
- Conditions
- Craniotomy Surgery, Regional Anaesthesia, Scalp Block, Plexus Block;Analgesia;Neurosurgery
- Trial name
- NCT07131046
- Testing
- Combination of superficial cervical plexus block and supraorbital block, Scalp block with bupivacaine alone
- Where
- Indonesia
- Volunteers
- 41 people
- Sponsor
- Universitas Indonesia
Cardiac Function and Hemodynamics
Cardiac and Vascular Responses to Creatine Supplementation in Elderly Men
The purpose of this study is to investigate the impact of creatine supplementation alone or in combination with a moderate session of physical activity on vascular reactivity and heart hemodynamics in elderly men.
- Trial name
- NCT05329480
- Testing
- Creatine Monohydrate, Maltodextrin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radford University
Septic Shock
Cerebral Hemodynamics and Oxygenation in Critically Ill Patients
Critically-ill patients frequently experience marked changes in mean arterial pressure and carbon dioxide partial arterial pressure, the two major determinants of the cerebral blood flow.
- Trial name
- NCT04690530
- Testing
- mechanical ventilation, Sedation
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS), Hepatic Cirrhosis
Evaluation of the Efficacy and Safety of Portal Pressure Gradient (PPG) Measurement Guided by Endoscopic Ultrasound (EUS) in the Therapeutic Algorithm of Patients with Liver Cirrhosis.
The development of Clinical significant PH (CSPH) is a major driver of complications. PPG is the strongest predictor of decompensation .
- Trial name
- GPP-USE (NCT06664307)
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Hospital Universitario Virgen Macarena
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis After Variceal Bleeding in Non-Responders
Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic…
- Conditions
- Gastrointestinal Hemorrhage, Portal Hypertension, Cirrhosis
- Trial name
- KT-2000 (NCT00450164)
- Testing
- esofagic varices ligation, Nadolol, Isosorbide mononitrate
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Energy Metabolism, Heart Rate
Effects of a Thermogenic Dietary Supplement on Metabolic, Hemodynamic, and Mood Responses
This a randomized, double blind, placebo controlled, crossover design study which measures the effect of an available thermogenic dietary supplement on resting energy expenditure (REE), blood pressure and heart rate, and mood…
- Conditions
- Energy Metabolism, Heart Rate, Blood Pressure, Mood
- Trial name
- NCT03678116
- Testing
- Caffeine (plus Teacrine and Cayenne), Caffeine (plus Teacrine)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Mary Hardin-Baylor
Septic Shock, Hemodynamic Instability
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand.
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Trial name
- NCT05225402
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Respiratory Abnormality, Pulmonary
The Study Examined the Acute Effects of Wim Hof on Aerobic Training and Cardiodynamics.
Researchers will split the sixty healthy smokers in half. Thirty people will serve as a control group and will be asked to walk or jog at a controlled pace for twelve minutes as part of an aerobic exercise program.
- Conditions
- Respiratory Abnormality, Pulmonary, Exercise Training
- Trial name
- NCT07399119
- Testing
- aerobic exercise where it included walking/ jogging with a controlled speed by the participant, Wim Hof Breathing Method
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Cairo University
Transcutaneous Nerve Stimulation
Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study
Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability.
- Trial name
- NCT02115841
- Testing
- "Enraf-Nonius" Muscle stimulator
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Septic Shock, Sepsis
Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock
Compare the effect of volume expansion by saline versus albumin on the correction of peripheral tissue hypoperfusion by measuring Index skin recoloration time (CRT) at H0 and H1
- Trial name
- REPTILOS (NCT05094856)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia
Does the Response to a Mini-fluid Challenge of 3ml/kg in 2 Minutes Predict Fluid Responsiveness for Pediatric Patient?
To predict fluid responsiveness in anesthetized pediatric patient is not an easy task although anesthesia provider has to deal with this question on their daily practices.
- Trial name
- PEDIFLUID (NCT02894996)
- Testing
- fluid challenge
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Coronary Disease Undergoing CABG
Assessment of Hemodynamic Response During Intubation Between Rigid Laryngoscopy and Track Light in Coronary Patients
Opioids provide greater patient comfort during intubation, but are not able to abolish completely the release adrenergic hormones during the laryngoscopy, which may cause undesirable hemodynamic changes.
- Trial name
- NCT01682707
- Testing
- laryngoscopy, track light
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Juiz de Fora
Intubation
Hemodynamic Response to Intubation
This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself.
- Trial name
- NCT02844894
- Testing
- Dexmedetomidine, Esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ufuk University
Pulmonary Arterial Hypertension
Hemodynamic Evaluation of Dose-response and Safety of Dry Powder Inhalation of Treprostinil
Acute and chronic hemodynamic dose-response and safety evaluation of LIQ861 in PAH subjects.
- Trial name
- NCT03884465
- Testing
- Inhaled dry powder treprostinil (LIQ861)
- Where
- 3 sites in France, Germany
- Volunteers
- 15 people
- Sponsor
- Liquidia Technologies, Inc.