Clinical trials: Hemodynamics Instability, open to volunteers
Hemodynamic Instability, Oxygen Consumption (V̇O2)
O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock
The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock.
- Trial name
- OxyCarDio (NCT07107724)
- Testing
- Noradrenalin, Fluid bolus
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Craniosynostoses, Hypovolemia
Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic…
- Conditions
- Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability
- Trial name
- CRASY-PRAM (NCT06263075)
- Testing
- Intraoperative monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Vascular Access, Elevated Jugular Venous Pressure
Ultrasound Assessment of Internal Jugular Vein for Cannulation and Venous Pressure Prediction
This prospective observational study aims to evaluate the diagnostic utility of vascular ultrasound for internal jugular vein (IJV) assessment in adult patients undergoing clinically indicated IJV cannulation.
- Conditions
- Vascular Access, Elevated Jugular Venous Pressure, Hemodynamic Instability
- Trial name
- NCT07773506
- Volunteers
- 100 people
- Sponsor
- Assiut University
HIE, TBI (Traumatic Brain Injury)
Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different…
- Conditions
- HIE, TBI (Traumatic Brain Injury), TBI, Hemodynamic Instability
- Trial name
- ICHOR 1 (NCT06195345)
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Cardiac Arrest, Cardiac Arrest Circulatory
Resuscitative TEE Collaborative Registry
The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and…
- Conditions
- Cardiac Arrest, Cardiac Arrest Circulatory, Cardiac Arrest, Out-Of-Hospital, Shock
- Trial name
- rTEECoRe (NCT04972526)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Hemodynamic Instability, Post-induction Hypotension (PIH)
Preoperative Neutrophil-to-Albumin Ratio and Post-Induction Hemodynamic Vulnerability in Major Oncologic Surgery
This prospective observational study aims to evaluate whether the preoperative neutrophil percentage-to-albumin ratio (NPAR) is associated with post-induction hemodynamic vulnerability in adult patients undergoing elective major…
- Trial name
- NCT07804706
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Hemodynamic Instability
Preoperative Ivabradine Doses for Hemodynamic Stability in FESS
This study compares two different preoperative doses of a heart-rate-lowering medication called ivabradine in patients undergoing endoscopic sinus surgery under general anesthesia.
- Trial name
- NCT07797946
- Testing
- Ivabradine 5 mg/5 mg regimen, Ivabradine 5 mg/7.5 mg regimen
- Volunteers
- 60 people
- Sponsor
- Minia University
Critically Ill, Haemodynamic Instability
Transducer Levelling Errors in Everyday ICU Practice - A Multicentre Blinded Observational Study
Invasive pressure monitoring (arterial blood pressure via arterial catheter and central venous pressure via central venous catheter) is fundamental to clinical decision-making in intensive care.
- Trial name
- NCT07330505
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Vastra Gotaland Region
Echocardiography, Hip Fractures
Preoperative Focused Cardiac Ultrasound in Hip Fracture Surgery (PrEcho)
The primary objective of this study is to investigate the impact of preoperative focused transthoracic ultrasound (FOCUS) on intraoperative hypotension and postoperative complications in hip fracture surgery.
- Conditions
- Echocardiography, Hip Fractures, Risk Assessment, Anesthesia
- Trial name
- PrEcho (NCT05862493)
- Testing
- FOCUS echocardiography
- Volunteers
- 100 people
- Sponsor
- Umeå University
Pulmonary Embolism (Diagnosis)
Inorganic Nitrates in Intermediate High-risk Pulmonary Embolism
Pulmonary embolism (PE) is a serious condition caused by blood clots blocking the blood vessels in the lungs. In some patients, PE leads to increased pressure in the lung circulation and strain on the right side of the heart.
- Trial name
- NITRATE-PE (NCT07431229)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska Institutet
Hemodynamics Instability, Arrhythmias Cardiac
Low and Moderete Flow Anaesthesia on Haemodynamics
The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.
- Conditions
- Hemodynamics Instability, Arrhythmias Cardiac, Cerebral Oxygenation
- Trial name
- NCT06871371
- Testing
- Sevoflurane (Volatile Anesthetic), low- medium flow anesthetic machine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Umraniye Education and Research Hospital
Efficacy, Self, Hemodynamic Instability
Pipeline Embolization for Intracranial Aneurysms
This study collected the clinical, laboratory, and imaging data from patients with intracranial aneurysms, who underwent Pipeline implantation.
- Conditions
- Efficacy, Self, Hemodynamic Instability, Stenosis, Aneurysm, Intracranial
- Trial name
- NCT06446778
- Testing
- Pipeline embolization device with or without shield technique
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhujiang Hospital
Pulmonary Embolism Acute
Hemodynamic and Respiratory Instability During Percutaneous Pulmonary Thrombectomy
Pulmonary embolism (PE) is a potentially life-threatening condition caused by the obstruction of pulmonary arteries by thrombi. Patients with high-risk or intermediate-high-risk PE may require immediate reperfusion therapies…
- Trial name
- INSTAB-PE (NCT07509541)
- Testing
- Percutaneous Pulmonary Thrombectomy (FlowTriever), Percutaneous Pulmonary Thrombectomy (Indigo)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Arterial Aneurysm Wall Enhancement on HRMRI
Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics
This project proposes to establish a prospective cohort of MIA based on a preexisting multicenter MIA database and to combine multidimensional methods such as high-resolution magnetic resonance, hemodynamics, ambulatory blood…
- Trial name
- NCT06539767
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Zhujiang Hospital
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Tricuspid Regurgitation, Heart Failure
Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study
TTVR-AHI is a multicenter, retrospective registry including heart failure patients displaying a severe and symptomatic tricuspid regurgitation (TR), deemed non-eligible to cardiac surgery and therefore treated with transcatheter…
- Conditions
- Tricuspid Regurgitation, Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- TTVR-AHI (NCT06954792)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Columbia University
Septic Shock, Microcirculatory Dysfunction
Papaverine and Sublingual Microcirculation in Septic Shock
This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult…
- Conditions
- Septic Shock, Microcirculatory Dysfunction, Sublingual Microcirculation, Hemodynamic Instability
- Trial name
- NCT07657741
- Testing
- Papaverine
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Cerebral Aneurysms, Intracranial Aneurysms
NOn-inVAsive Blood Pressure Monitoring in Intracranial Aneurysm Embolization
The goal of this clinical trial is to evaluate whether non-invasive continuous blood pressure monitoring (NVBP) using the ClearSight system can safely serve as an alternative to radial arterial catheterization for invasive…
- Conditions
- Cerebral Aneurysms, Intracranial Aneurysms, Coil Embolization, Hemodynamic Instability
- Trial name
- NOVA (NCT07246148)
- Testing
- Non-invasive continuous blood pressure monitoring, Invasive arterial blood pressure monitoring
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Korea University Anam Hospital
Pheochromocytoma, Paraganglioma
Prospective Cohort Study of Pheochromocytoma/Paraganglioma
The study will enroll patients scheduled for PPGL removal surgery at Peking Union Medical College Hospital. Before surgery, researchers will use a 6-variable model to predict the patient's risk of experiencing severe blood…
- Conditions
- Pheochromocytoma, Paraganglioma, Hemodynamic Instability, Intraoperative Complications
- Trial name
- NCT07516275
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital