Clinical trials: Hepatitis B Vaccination
Hepatitis B
Immunogenicity and Safety of Primary and Booster Vaccination With DTPa-HBV-IPV/Hib Vaccine
This study will assess the immunogenicity, safety and reactogenicity of GSK Biological's DTPa-HBV-IPV/ Hib vaccine as compared to GSK's DTPa-IPV/Hib vaccine co-administered with HBV according to a three-dose immunisation course…
- Trial name
- NCT00880477
- Testing
- DTPa-HBV-IPV/Hib vaccine, DTPa-IPV/Hib vaccine, EngerixTM-B
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis B, Immune Response
Seroprevalence of Hepatitis B and Immune Response to Hepatitis B Vaccination in Chinese College Students
At present, children less than 15 y of age have been regarded as a key group for hepatitis B immunization in China. However, there is not yet special immunization strategy for population above 15 y of age.
- Conditions
- Hepatitis B, Immune Response, Seroprevalence
- Trial name
- NCT01861613
- Testing
- HBV vaccine (Engerix-B, recombinant hepatitis B surface antigen, 20µg/mL/vial, GlaxoSmithKline, Belgium)
- Where
- China
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Hui Zhuang
End Stage Renal Disease
Safety and Immunogenicity of HEPLISAV™ a Hepatitis B Virus Vaccine in Adults on Hemodialysis
The purpose of this study is to compare the immune response to HEPLISAV™ booster injection with the immune response to Engerix-B® and Fendrix® booster vaccinations among patients with end stage renal disease (ESRD) on…
- Trial name
- NCT01195246
- Testing
- HEPLISAV, Engerix-B, Fendrix
- Where
- 19 sites in Germany
- Volunteers
- 155 people
- Sponsor
- Dynavax Technologies Corporation
Hepatitis B, Chronic Hepatitis B
TLR-9 Adjuvanted Vaccination for Chronic Hepatitis B
The goal of this clinical trial is to learn if HEPLISAV-B, a vaccine that is approved to prevent hepatitis B infection in people that are not already infected, is safe in people already chronically infected with hepatitis B.
- Trial name
- BOOST-9 (NCT04843852)
- Testing
- Hepatitis B Vaccine Recombinant, Adjuvanted Intramuscular Solution [HEPLISAV-B]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Pain, Analgesia
Non-Pharmacologic Interventions to Relief Pain in Healthy Newborns Submitted to Vaccination to Hepatitis B
Acute procedural pain in neonates may be alleviated by non-pharmacological procedures. This study objective is to test the efficacy regarding pain attenuation of 3 interventions (skin-to-skin contact versus glucose 25% versus…
- Trial name
- NCT00713986
- Testing
- Water 2mL PO 2 minutes prior to intra-muscular injection, skin-to-skin contact, Glucose 25% 2 mL PO 2 minutes prior to injection
- Volunteers
- 640 people
- Sponsor
- Federal University of São Paulo
Hepatitis B, Cirrhosis
Phase III, Study to Evaluate the Efficacy of Two Different HBV Vaccination Schemes in Patients With Hepatic Cirrhosis
The objective of this clinical trial is to compare the response rate obtained with two different vaccination schemes against HBV in cirrhotic patients.
- Conditions
- Hepatitis B, Cirrhosis, Awaiting Organ Transplant
- Trial name
- NCT01884415
- Testing
- HBV vaccine
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Chronic Hepatitis b
Evaluation of the Novel Therapeutic Hepatitis B Virus Synthetic Long Peptide Vaccination ISA104
The goal of this clinical trial is to test ISA104 in patients with chronic hepatitis B. The main question[s] it aims to answer are: How safe is ISA104? Does ISA104 induce immunity against hepatitis B virus? Different doses of the…
- Trial name
- HEB-PEP (NCT05841095)
- Testing
- ISA104
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Erasmus Medical Center
Hepatitis B Vaccine
Immunogenicity and Persistence of Hepatitis B Vaccination in HIV-Infected Patients
At present, HIV-Infected Patients of Hepatitis B Vaccination in are vaccinated with hepatitis B vaccine according to the standard three-dose schedule immunization program, and the effect of preventing HBV infection is not ideal.
- Trial name
- NCT03962803
- Testing
- 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6, 20 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6, 60 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanxi Medical University
Hepatitis B
A Study to Assess the Anamnestic Immune Response in Healthy 4 to 7 Year-old Children After a Primary Vaccination Series With Either HEXAVAC® or INFANRIX®-HEXA
Primary objective: To describe in subjects vaccinated with 3 doses of HEXAVAC® or 3 doses of INFANRIX®-HEXA during the first two years of life the percentage of subjects with an anti-HBs antibody titre ≥10 mIU/mL 1 month after a…
- Trial name
- NCT00693186
- Testing
- HBVaxPRO® 5 µg / 0.5 mL, Engerix B® 10 µg / 0.5 mL
- Where
- 5 sites in Italy
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Hepatitis B, Vaccination
Assessing the Reliability of Self-Reported Hepatitis B Vaccination Status in Outpatients: Evaluation of Individuals Born in France and Consulting at the CeGIDD in Saint-Denis.
This study aims to find out whether people accurately know their hepatitis B vaccination status. It focuses on individuals born in France who visit a sexual health clinic (CeGIDD) in Saint-Denis.
- Conditions
- Hepatitis B, Vaccination, Health Knowledge, Attitudes, Practice, Serologic Tests
- Trial name
- NCT06998992
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Hepatitis B Vaccines
Study of the Long Term Efficacy of Recombinant Hepatitis B Vaccine in Nile Delta of Egypt
More than two billion individuals have serological evidence of hepatitis B virus (HBV) infection worldwide. Of these, 240 million are chronic carriers and approximately 786,000 hepatitis B related deaths occur annually.
- Trial name
- NCT02797782
- Testing
- Detection of anti HBs antibody titer
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sherief Abd-Elsalam
Hepatitis B, Vaccination
Long Term Immunogenicity Study of Engerix-B Vaccine in 10 Year Old Children and the Effect of Booster Injections
Hepatitis B immunization has been offered to all grade 4 students (age 9-10) in the province of Quebec, using Engerix-B at a dose of 10 mkg.
- Trial name
- NCT00169858
- Testing
- Engerix-B
- Where
- Canada
- Volunteers
- 1,129 people, healthy volunteers welcome
- Sponsor
- Laval University
Liver Neoplasms, Hepatitis B
Lay Health Worker Model to Reduce Liver Cancer Disparities in Asian Americans
The study was conducted between April 2013 and October 2014. In the parent study, 600 foreign-born Asian American adults 18 years of age and older were drawn from the community in the Baltimore Washington Metropolitan Area.
- Trial name
- LHWAA (NCT02760537)
- Testing
- Lay Health Worker Intervention
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Hepatitis B, Healthy
First in Human Study of ChAdOx1-HBV in Healthy Participants and Participants With Chronic hepB Infection
This is a Phase 1, first in human study of ChAdOx1-HBV. The study will be conducted in 40 healthy participants and 12 participants with CHB and virally suppressed with oral antiviral medication.
- Trial name
- NCT04297917
- Testing
- ChAdOx1-HBV
- Where
- 4 sites in United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Type 1 Diabetes Mellitus
Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-1).
Observational study about adherence to guidelines for Influenza, Pneumococcal and Hepatitis B Vaccination in adult patients with type 1 Diabetes mellitus.
- Trial name
- AVADI-1 (NCT03478254)
- Testing
- Influenza vaccination, Pneumococcal vaccination, Hepatitis B Virus (HBV) vaccination
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Jesús Moreno Fernández
Chronic Hepatitis B
Hepatitis B Vaccine in Chronic Hepatitis B Patients With Low Serum HBsAg
Background: The HBsAg clearance rate in interferon-treated responders is significantly higher than that in lamivudine-treated responders, implying immune control is the key to HBsAg clearance.
- Trial name
- NCT01817725
- Testing
- HBV vaccine (Engerix B)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chang Gung Memorial Hospital
Hepatitis B
A Hepatitis B Vaccine Challenge Study After Previous Vaxelis® Vaccination (V419-013)
The purpose of this study is to demonstrate the durability of protection against hepatitis B virus (HBV) infection approximately 8-9 years after vaccination with Vaxelis®.
- Trial name
- NCT04490499
- Testing
- HBVAXPRO™
- Where
- 10 sites in Finland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy, no Evidence of Disease
Edible Hepatitis B Vaccine Therapy in Healthy Participants Who Have Undergone Previous Vaccination
RATIONALE: Hepatitis B antigen peptide (HBsAg) vaccine may help the body build an immune response and help prevent hepatitis B. PURPOSE: This clinical trial studies edible HBsAg vaccine therapy in healthy participants who have…
- Trial name
- NCT01292421
- Testing
- hepatitis B antigen peptide, immunoenzyme technique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
HIV Infections, Hepatitis A
Hepatitis Vaccination in HIV Infection: Role of Adjuvant Interleukin-2
The response to vaccination for hepatitis is reduced in patients with HIV infection. The hypothesis of the study is that adjuvant interleukin-2 administered subcutaneously at the time of vaccination improves the response rate.
- Conditions
- HIV Infections, Hepatitis A, Hepatitis B
- Trial name
- HEPVACHIV (NCT00451984)
- Testing
- Twinrix, interleukin-2
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Aalborg University Hospital
Hepatitis B
Immunogenicity of 2 Versus 3 Doses of Combined Hepatitis B Vaccines in 2-18 Months Old Children
The main objective of this study is to compare the immunogenicity of the hepatitis B component in children vaccinated with (I) two doses of Infanrix-hexa administered at 2 and 12 months of age versus (II) one dose of…
- Trial name
- NCT04294433
- Testing
- Infanrix-hexa, Infanrix-hexa and Twinrix Junior
- Where
- 2 sites in Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Laval University