Clinical trials: Herniation, Disc
Lumbar Disc Herniation
Perioperative Outcome of Corticosteroids in Transforaminal Endoscopic Lumbar Discectomy
The endoscopic discectomy has rapidly developed and increased need by patients. This procedure is widely performed by interventional pain physicians as well as by spine surgeons because it requires no general anesthesia or…
- Trial name
- NCT03273036
- Testing
- 40 mg Triamcinolone acetate 1 cc
- Volunteers
- 30 people
- Sponsor
- Ramathibodi Hospital
Lumbar Disc Herniation
Tramadol vs.Tramadol With Paracetamol
This study focused on to determine postoperative analgesic efficacy of tramadol compared to tramadol with addition of paracetamol after a lumbar disc surgery.
- Trial name
- NCT03482492
- Testing
- Tramadol, Paracetamol
- Volunteers
- 60 people
- Sponsor
- Yeditepe University Hospital
Intervertebral Disk Degeneration, Intervertebral Disk Displacement
Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™
Anterior cervical discectomy and fusion (ACDF) has shown good treatment results for a variety of cervical spine diseases such as herniated intervertebral disc (HIVD), cervical spondylotic radiculopathy (CSR) and cervical…
- Conditions
- Intervertebral Disk Degeneration, Intervertebral Disk Displacement, Ossification of Posterior Longitudinal Ligament
- Trial name
- NCT01615328
- Testing
- Cervios ChronOs, Bonion
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Seoul National University Hospital
Spinal Stenosis, Low Back Pain
Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis
This study tests the effectiveness of different treatments for the three most commonly diagnosed conditions of the lower backbone (lumbar spine).
- Trial name
- NCT00000411
- Testing
- Decompressive laminectomy, Non-surgical treatments
- Where
- 13 sites in United States
- Volunteers
- 289 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nurses, Comfort
The Effect of Kegel Pelvic Floor Muscle Exercises on Urinary Retention, Pain, and Comfort Levels in Patients After Lumbar Disc Herniation Surgery: A Randomized Controlled Clinical Trial
This study was planned as a randomized controlled trial to investigate the effects of Kegel pelvic floor muscle exercises on urinary retention and comfort levels of patients after lumbar disc herniation surgery.
- Conditions
- Nurses, Comfort, Surgery
- Trial name
- NCT06578221
- Testing
- Kegel Pelvic Floor Muscle Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pain, Chronic
Comparison of Unilateral and Bilateral Transforaminal Epidural Steroid Injection
Lumbar radicular pain affects the person's quality of life. The most common cause of lumbar radicular pain is disc herniation. In radicular pain due to lumbar disc herniation, epidural steroid injections are frequently applied to…
- Trial name
- NCT06240793
- Testing
- unilateral transforaminal epidural steroid block, bilateral transforaminal epidural steroid block
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara University
Lumbar Disc Herniation
An mTLIP Block for Analgesia Management After Lumbar Spinal Surgery.
Pain management is an important issue following lumbar spinal surgery. Wound infiltration is a technique that a local anesthetic solution is infiltrated into the tissues around the surgical area.
- Trial name
- NCT03967314
- Testing
- TLIP block group (group T), Wound infiltration group (group W)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Hernia
DISCOGEL ®: Evaluation of the Procedure DISCOGEL ® in Lumbar Radiculopathy on Slipped Disc
Lumbar disc herniation is the most important and frequent affection in rheumatology. The first treatment is based on an non-steroidal anti-inflammatory drugs.Physiotherapy also is used.But when there is no efficient result, it's…
- Trial name
- NCT03309371
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Low Back Pain, Spondylolisthesis
Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device
Lumbar spinal fusion is commonly performed as a "last resort" in patients with chronic low back pain caused by degenerative changes and instability of the spine.
- Conditions
- Low Back Pain, Spondylolisthesis, Spinal Stenosis, Intervertebral Disc Displacement
- Trial name
- NCT00095095
- Testing
- Lumbar Interbody Fusion
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 102 people
- Sponsor
- Medtronic Spinal and Biologics
Sciatica, Herniated Disc
Study of REN-1654 in Patients With Sciatica Pain
The purpose of this study is to gain initial safety and efficacy data on the experimental agent REN-1654 in patients with pain that radiates down the leg(s), and is typical of sciatica (lumbosacral radiculopathy).
- Conditions
- Sciatica, Herniated Disc, Radiculopathy
- Trial name
- NCT00107055
- Testing
- REN-1654
- Where
- 19 sites in United States
- Volunteers
- 72 people
- Sponsor
- Renovis
Lumbar Disc Herniation
Repairing the Defect of Intervertebral Disc With Autologous BMSC and Gelatin Sponge After Microendoscopic Discectomy for Lumbar Disc Herniation
In this prospective study the investigators seek to evaluate clinical outcomes after repairing the defect of intervertebral disc with autologous BMSC/gelatin sponge during microendoscopic discectomy for participants of lumbar…
- Trial name
- NCT03002207
- Testing
- Autologous Bone Marrow Stem Cell (BMSC)/gelatin sponge, The defect is sutured
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Zhanghao
Disk Herniated Lumbar, Radicular Pain
Percutaneous Intradiscal Radiofrequency as A Treatment for Radicular Pain From Lumbar Disc Herniation
The goal of this clinical trial is to demonstrate the efficacy of percutaneous intradiscal radiofrequency as a treatment for radicular pain from lumbar disc herniation.
- Conditions
- Disk Herniated Lumbar, Radicular Pain, Intradiscal Radiofrequency
- Trial name
- NCT05747807
- Testing
- Percutaneous intradiscal radiofrequency treatment
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Chulalongkorn University
Low Back Pain, Inflammatory Response
The Effect of Resolvins on the Resolve of Inflammatory Low Back Pain
Brief Summary: Inflammatory back pain is a chronic condition localized in the axial spine and sacroiliac joints.1 It often accompanies mechanical issues like lumbar disc herniation.
- Conditions
- Low Back Pain, Inflammatory Response, Lumbar Disc Herniation
- Trial name
- NCT06356844
- Testing
- Resolvin supplement
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Low Back Pain, Low Back Pain, Mechanical
Effects of Mechanical Versus Manual Traction in the Management of Low Back Pain.
This study compared the effects of mechanical and manual traction on pain, disability and lumbar spinal curvature in patients with discogenic low back pain
- Conditions
- Low Back Pain, Low Back Pain, Mechanical, Disc Degeneration, Disc Prolapse
- Trial name
- NCT05059249
- Testing
- Hot Pack, Manual Traction, Mechanical Traction
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
Pain
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
The analgesic effect of dexamethasone is not well described, but studies have shown that dexamethasone can be a safe part of a multimodal analgesic strategy after surgery.
- Trial name
- NCT01953978
- Testing
- Dexamethasone, Morphine, Zofran
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lumbar Disc Herniation, Chronic Low Back Pain
High-Intensity Laser Therapy Versus Transforaminal Epidural Steroid Injection in Chronic Lumbar Disc Herniation-Related Low Back and Radicular Pain
This prospective, randomized, single-blinded, controlled clinical trial aims to compare the effectiveness of high-intensity laser therapy and fluoroscopy-guided transforaminal epidural steroid injection in patients with chronic…
- Conditions
- Lumbar Disc Herniation, Chronic Low Back Pain, Radicular Pain, Lumbar Radiculopathy
- Trial name
- NCT07688915
- Testing
- High-Intensity Laser Therapy, Transforaminal Epidural Steroid Injections
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Spine Disc Herniation
Lumbar Discectomy Control Study, Risk Factors for Reherniation
The purpose of this 12-month, prospective, multicenter study is to investigate the effect of annular defect size and other risk factors on reherniation and associated costs in primary lumbar discectomy patients.
- Trial name
- NCT02477176
- Testing
- Discectomy
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Intrinsic Therapeutics
Degenerative Disc Disease, Herniated Disc
Bone Graft Materials Observational Registry
A multi-center, prospective, observational patient registry to collect information on the clinical outcomes and "real world" use of approved and commercially available bone graft substitutes, autograft and allograft.
- Conditions
- Degenerative Disc Disease, Herniated Disc, Spinal Stenosis, Spondylolithesis
- Trial name
- APPROACH-001 (NCT00974623)
- Testing
- Bone graft substitute, autograft or allograft
- Where
- 14 sites in United States, Hungary and 1 more
- Volunteers
- 329 people
- Sponsor
- Baxter Healthcare Corporation
Intervertebral Disc Degeneration, Intervertebral Disc Displacement
Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study
A safety and feasibility study of free-run and stimulated corporal electromyography (EMG) to assess autonomic neural function during spinal and/or pelvic surgery in women and men.
- Conditions
- Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Stenosis
- Trial name
- NCT02873182
- Testing
- Autonomic nervous system monitoring
- Volunteers
- 20 people
- Sponsor
- Stanley Skinner