Clinical trials: Herniation, Disc
Lumbar Disc Herniation, Chronic Low Back Pain
PTED Versus Radiofrequency Ablation for Lumbar Disc Herniation
Lumbar disc herniation (LDH) is a common and frequently-occurring disease giving rise to low back pain and (or) leg pain. There are about 1.5 million people with LDH-related pain, accounting for 10% of outpatients each year in…
- Trial name
- PTED (NCT03634046)
- Testing
- Percutaneous transforaminal endoscopic discectomy, Radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Intervertebral Disc Displacement, Spinal Stenosis Lumbar
Artificial Intelligence Enabled Decision Support for Selection of Patients for Lumbar Spine Surgery
Background One third of patients operated for lumbar disc herniation (LDH) or spinal stenosis (LSS) do not achieve substantial improvement.
- Conditions
- Intervertebral Disc Displacement, Spinal Stenosis Lumbar, Lumbar Disc Herniation, Lumbar Spine Degeneration
- Trial name
- NCT06806969
- Testing
- Decision support
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- University Hospital of North Norway
Cervical Disc Herniation, Lumbar Disc Herniation
The Value of Short-term Pain Relief for the Prediction of Long-term Outcome After Cervical or Lumbar Nerve Root Infiltration
The purpose if this study is to assess the response to nerve root infiltration therapy in patients with cervical or lumbar disc herniations.
- Trial name
- InfStu (NCT01945554)
- Testing
- Cervical nerve root infiltration, Lumbar nerve root infiltration, Mephamesone
- Where
- 3 sites in Switzerland
- Volunteers
- 250 people
- Sponsor
- Holger Joswig
Protruded Disk
CLARIX™ 100 & CLARIX CORD 1K for Discectomy Patients
The purpose of the study is to evaluate the efficacy of CLARIX™ 100 and CLARIX™ CORD 1K as a tissue barrier when used as an annular patch in discectomy patients with low back \& leg pain when compared to traditional discectomy…
- Trial name
- NCT03113786
- Testing
- CLARIX™100, CLARIX CORD 1K
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Amniox Medical, Inc.
Chronic Low-back Pain, Herniated Disc
LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant
The study is a post-market surveillance study of the Lumbar Implant for Stiffness Augmentation (LISA), a medical device, which is used to treat low-back pain that accompanies degenerative lesions of grades II, III, and IV…
- Conditions
- Chronic Low-back Pain, Herniated Disc, Degenerative Disc Disease, Lumbar Canal Stenosis
- Trial name
- LISA-PMCF (NCT04631133)
- Testing
- Lumbar Implant for Stiffness Augmentation (LISA)
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 136 people
- Sponsor
- BACKBONE
Symptomatic Lumbar Disc Herniation, Symptomatic Grade I Lumbar Spondylolisthesis
Neurosurgery Patient Outcomes in Treating Spinal Disorders
The creation of a multi-center cooperative research group encompassing academic and community-based spinal practices . . .
- Trial name
- Neuropoint SD (NCT01220921)
- Testing
- Lumbar Discectomy, Single-level lumbar fusion
- Where
- 13 sites in United States, Canada
- Volunteers
- 198 people
- Sponsor
- Greenwich Hospital
Prolapsed Intervertebral Disc
Effects of Lumbar Traction on the Straight Leg Raise Test and Pain
Disc prolapse causes impairment of function by nerve root compression compelling the patient to seek medical advice for low backache.
- Trial name
- NCT04728685
- Testing
- Mechanical Traction
- Where
- Saudi Arabia
- Volunteers
- 45 people
- Sponsor
- King Saud University
Lumbar Disc Herniation
Comparison Between Insertion of Bilateral Straight Cages Versus Unilateral Banana Cage in Lumbar Fusion Surgery
To compare the clinical outcomes of bilateral straight cages and unilateral banana cage insertion in lumbar interbody fusion surgery, assess radiological outcomes, including intervertebral disc height, lumbar lordosis angle, and…
- Trial name
- NCT07312747
- Testing
- cages in lumbar fusion surgery
- Volunteers
- 30 people
- Sponsor
- Assiut University
Disc Herniation
Assessment of Unilateral Biportal Endoscopy Technique Applied to Treatment of Degenerative Lumbar Pathologies
Lumbar disc herniation (HDL) is one of the main causes for low back pain and sciatica. Although non surgical care remains the gold standard as first treatment, lumbar discectomy is used to effectively relieve symptoms that…
- Trial name
- UBEVAL (NCT06448416)
- Testing
- UBE
- Where
- France
- Volunteers
- 500 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Sciatic Neuropathy, Radiculopathy
Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block
The purpose of this study is to determine if participation in physical therapy in conjunction with a selective nerve root block in the lumbar spine is more effective than just receiving the injection alone for patients with low…
- Conditions
- Sciatic Neuropathy, Radiculopathy, Intervertebral Disk Displacement
- Trial name
- NCT00934284
- Testing
- Lumbar injection, Rehabilitation following lumbar injection
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Utah
Lumbar Spine Disc Herniation
Targeted Disc Decompression (TDD) for Contained Herniated Lumbar Discs
The prospective Clinical Series (CS) aims to prove the hypothesis that Targeted Disc Decompression (TDD) reduces the pain in patients suffering from radicular leg pain secondary to a contained focal disc protrusion…
- Trial name
- TDD (NCT01429363)
- Testing
- Targeted disc decompression
- Where
- 3 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- Rijnstate Hospital
Lumbago, Lumbar Spinal Stenosis
Post Epidural Steroid Injection Follow-up
To determine the expected pain response timeline for patients receiving epidural steroid injections, our team plans to assess patient pain severity and degree of pain relief every 3 days for 23 days.
- Conditions
- Lumbago, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- NCT04207606
- Testing
- Post Epidural Steroid Injection Follow-up
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Lumbar Radiculopathy, Lumbar Herniated Disk
Does Intraoperative Application of Steroids Affect Early Outcomes in Patients Undergoing Endoscopic Lumbar Discectomy?
Prospective randomised trial assessing whether intraoperative application of steroids leads to better clinical outcomes in patients submitted to lumbar discectomy
- Trial name
- NCT07411326
- Testing
- Intervention Group, Control group (Normal Saline) (C)
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Intervertebral Disc Displacement
Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Spacer Squale (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
This is an investigator-initiated study. The primary goal is to evaluate the efficacy of two different cervical disc devices (prosthesis vs rigid spacer) with respect to postoperative change in neck disability index.
- Trial name
- NCT02936765
- Testing
- Anterior cervical discectomy with prosthetic disc replacement / ESP., Anterior cervical discectomy with prosthetic disc replacement / Squale.
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Technische Universität Dresden
Intervertebral Disc Protrusion
Mulligan SNAG Technique in Individuals With Lumbar Intervertebral Disc Protrusion
This study aimed to examine the effects of the Mulligan SNAG mobilization technique, applied in addition to conventional physiotherapy on the structure of the intervertebral disc and physical functioning in patients diagnosed…
- Trial name
- NCT06521294
- Testing
- Mulligan SNAG mobilization tecnique, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Biruni University
Intervertebral Disc Herniation
Preoperative Estimation Of Disc Herniation Recurrence In Patients With Lumbar Disc Herniation
This study will be conducted at Research Institute of Traumatology and Orthopedics (NRITO) n.a. Ya.L.Tsivyan, Novosibirsk, Russia.
- Trial name
- NCT04254250
- Testing
- Preoperative risk estimation of disc herniation recurrence
- Where
- 2 sites in Russia
- Volunteers
- 386 people
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Lumbar Disc Herniation
Lumbar Disc Hernia, Erector Spinae Plane Block, Ilesi
The study is designed as an observational study. Patients who have been treated and completed treatment for lumbar discopathy in our clinic will be followed.
- Trial name
- NCT07184554
- Testing
- us-guided espb, fl-guided Ilesi
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Diskapi Teaching and Research Hospital
Cervical Radiculopathy, Cervical Spondylosis
Effectiveness of Cervical Transforaminal Epidural Steroid Injection
Study Purpose: This study is intended to monitor outcomes for 1 year following cervical TFESI. Based on current clinic volume and enrollment rates into a current study of cervical epidural injections that is nearing completion…
- Conditions
- Cervical Radiculopathy, Cervical Spondylosis, Disk, Herniated
- Trial name
- NCT04544683
- Testing
- Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Utah
Lumbar Disc Herniation, Degenerative Disc Disease
Peri-Incisional Drug Injection in Lumbar Spine Surgery
This is a randomized prospective study that will compare the use of narcotics in a control group of non-injected patients with a treatment arm of patients injected intra-operatively with a ropivacaine, morphine, and epinephrine…
- Conditions
- Lumbar Disc Herniation, Degenerative Disc Disease, Spondylolisthesis
- Trial name
- NCT03513445
- Testing
- Morphine, Epinephrine, naropin
- Where
- United States
- Sponsor
- University of Minnesota
Lumbar Disc Herniation
The Efficacy of Clinical Pilates Exercises on Individuals With Lumbar Disc Herniation
The aim of the study is to determine the effects of clinical Pilates Exercises on the level of pain, functional status, flexibility, static and dynamic endurance of the truncus muscles and quality of life in patients with lumbar…
- Trial name
- NCT03198273
- Testing
- Clinical pilates exercises, physiotherapy program
- Where
- Cyprus
- Volunteers
- 88 people
- Sponsor
- Eastern Mediterranean University