Clinical trials: Heterogeneous Emphysema
Heterogeneous Emphysema
Use of Endobronchial Valves in Non-Upper Lobe Heterogeneous Emphysema
Hypothesis: Patients with advanced emphysema with predominance of the disease in areas other than the upper lobes, as determined by high resolution computed tomography (HRCT), could have a positive response to valve treatment.
- Trial name
- NCT00825578
- Testing
- Intra-bronchial valve (Spiration IBV)
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD, Heterogeneous Emphysema
To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves
To compare the clinical outcomes of Endoscopic Lung Volume Reduction (ELVR) using Pulmonx Zephyr Valves vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema subjects in a controlled trial design setting.
- Trial name
- TRANSFORM (NCT02022683)
- Testing
- ELVR (Endoscopic Lung Volume Reduction) with Zephyr Valves
- Where
- 17 sites in Belgium, France and 4 more
- Volunteers
- 97 people
- Sponsor
- Pulmonx Corporation
Pulmonary Emphysema
Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE)
The purpose of this study is to demonstrate the safety and efficacy of AeriSeal System treatment plus optimal medical therapy compared in patients with advanced upper lobe predominant (ULP) heterogeneous emphysema.
- Trial name
- ASPIRE (NCT01449292)
- Testing
- Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
- Where
- 40 sites in United States, France and 5 more
- Volunteers
- 300 people
- Sponsor
- Aeris Therapeutics
Chronic Pulmonary Obstructive Disease, Emphysema
A Registry Study of the AeriSeal® System or Lung Volume Reduction in Patients With Advanced Emphysema
The purpose of this study is to provide post market clinical follow-up (PMCF) to obtain long term safety and efficacy information about the AeriSeal System treatment in patients with advanced emphysema.
- Trial name
- NCT01449175
- Where
- 8 sites in Austria, France and 2 more
- Volunteers
- 54 people
- Sponsor
- Aeris Therapeutics
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Heterogeneous Emphysema
Endoscopic Lung Volume Reduction After Catheter-based CV Measurement in Patients With Heterogeneous Emphysema and Complete Interlobar Fissures
This clinical trial evaluates the impact of catheter-based measurement of interloabr collateral ventilation prior to endoscopic lung volume reduction in patients with hetereogeneous emphysema and complete interlobar fissures in…
- Trial name
- NCT01902732
- Testing
- Implantation of valves (IBV)
- Where
- 5 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Pulmonary Emphysema
Post Market Registry Study of the AeriSeal System
Obtain and analyze medical record data on patients with advanced emphysema who receive treatment with the AeriSeal System to better understand safety and effectiveness in the post-market setting; Provide participating physicians…
- Trial name
- NCT01520064
- Where
- 12 sites in Germany, Israel
- Volunteers
- 25 people
- Sponsor
- Aeris Therapeutics
Pulmonary Emphysema
Collateral Ventilation Effects on Response to AeriSeal System Treatment in Upper Lobe Predominant Emphysema
This study will evaluate the effects of baseline collateral ventilation status on outcomes following treatment with AeriSeal System in patients with advanced upper-lobe predominant heterogenous emphysema.
- Trial name
- CV+/- (NCT01520740)
- Testing
- Emphysematous Lung Sealant
- Where
- 13 sites in Germany, Israel
- Volunteers
- 100 people
- Sponsor
- Aeris Therapeutics
Emphysema
Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema
The investigators plan to perform a randomized controlled trial that compares bilateral lung volume reduction surgery (LVRS) with bronchoscopic lung volume reduction (BLVR) using endobronchial valves in terms of efficacy and…
- Trial name
- SINCERE (NCT04537182)
- Testing
- Lung volume reduction surgery, Bronchoscopic lung volume reduction with valves
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 120 people
- Sponsor
- Isabelle Opitz, Professor, MD
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
AeriSeal System for Lung Volume Reduction
The purpose of this study is to evaluate the safety and efficacy of AeriSeal treatment in patients with advanced emphysema.
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Emphysema, Lung Diseases
- Trial name
- NCT01051258
- Testing
- AeriSeal System
- Where
- 8 sites in Austria, France and 2 more
- Volunteers
- 55 people
- Sponsor
- Aeris Therapeutics
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To establish and confirm the safety and clinical utility of BTVA applied unilaterally for lung volume reduction in patients with upper lobe predominate heterogeneous severe emphysema.
- Trial name
- BTVA (NCT01102712)
- Testing
- BTVA System
- Where
- 10 sites in Australia, Austria and 2 more
- Volunteers
- 34 people
- Sponsor
- Uptake Medical Corp
Chronic Obstructive Pulmonary Disease, Emphysema
Endobronchial Valve in Patients With Heterogeneous Emphysema
To compare the clinical outcomes of Endoscopic Lung Volume Reduction using Pulmonx Zephyr Endobronchial Valve (EBV) vs. Standard of Care (SoC) in the treatment of heterogeneous emphysema patients in a controlled trial design…
- Trial name
- NCT02823223
- Testing
- Zephyr endobronchial valve placement
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese PLA General Hospital
Heterogeneous Emphysema
Efficacy and Safety of Transbronchial Bronchoscopic Thermal Vapor Ablation (BTVA) in Heterogeneous Emphysema
Efficacy and Safety of Transbronchial BTVA in Heterogeneous Emphysema: A Prospective, Single-Arm, Multicenter Clinical Study
- Trial name
- NCT06642038
- Testing
- Transbronchial Endoscopic Thermal Vapor Ablation
- Volunteers
- 51 people
- Sponsor
- Ye Gu
Pulmonary Emphysema
Unilateral Versus Bilateral Endoscopic Lung Volume Reduction A Comparative Case Study
Patients with bilateral heterogeneous pulmonary emphysema benefit to differing degrees from unilateral ELVR with complete lobe closure in comparison with incomplete bilateral treatment.
- Trial name
- NCT00995852
- Testing
- IBV Implantation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heidelberg University
Emphysema
A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)
Use of the Chartis® Assessment System prior to EBV Treatment
- Trial name
- NCT01101958
- Testing
- Chartis System, Endobronchial Valve (EBV) Treatment
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Pulmonx Corporation
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To assess the safety and efficacy of BTVA for the treatment of patients with heterogeneous upper lobe emphysema.
- Trial name
- BTVA (NCT01041586)
- Testing
- BTVA System
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Uptake Medical Corp
Pulmonary Emphysema
Implantation of Endobronchial Valves Versus Intrabronchial Valves in Patients With Severe Heterogeneous Emphysema
Patients with advanced heterogeneous emphysema experience improvement in clinical outcomes in the same way following either implantation of endobronchial valves or intrabronchial valves.
- Trial name
- NCT01457833
- Testing
- EBV implantation, IBV implantation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Heterogeneous Emphysema
Safety and Feasibility Study of the Chartis System With Heterogeneous Emphysema Prior to Endobronchial Lung Volume Reduction (ELVR)
The purpose of this study is to evaluate the safety and feasibility of the Chartis System in measuring air flow and pressures in isolated lung compartments in emphysema patients prior to endobronchial lung volume reduction (ELVR).
- Trial name
- NCT00684892
- Testing
- Chartis System
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Pulmonx Corporation
Pulmonary Emphysema
US 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study - Initial Formulation
The purpose of this study is to determine whether the Aeris Bronchoscopic Lung Volume Reduction (BLVR) System is safe in patients with advanced emphysema.
- Trial name
- NCT00085852
- Testing
- BLVR
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Aeris Therapeutics
Emphysema
A Randomized Controlled Trial of InterVapor® in France - The TARGET Trial
This study is designed to prospectively document changes in FEV1 and health-related quality of life 12 months following sequential segmental treatment with InterVapor® in patients with heterogeneous emphysema with upper lobe…
- Trial name
- NCT05118269
- Testing
- Treatment plus Optimal Medical Therapy, Optimal Medical Therapy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Uptake Medical Technology, Inc.