Clinical trials: High Flow Oxygenation
Chest Trauma
High Flow Nasal Oxygenation Versus Non-invasive Ventilation for Patients With Blunt Chest Trauma
Chest trauma remains an issue for health services for both severe and apparently mild trauma management. Severe chest trauma is associated with high mortality and is liable for 25% of mortality in multiple traumas.
- Trial name
- NCT05342103
- Testing
- high flow oxygenation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Huda Fahmy Mahmoud, PhD
Hypoxemic Respiratory Failure
A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Our main objective is to collect feasibility data on helmet NIPPV and other clinical elements in to eventually prepare for a full scale randomized trial based on findings of this pilot study.
- Trial name
- NOVA-pilot (NCT04035460)
- Testing
- Helmet, High Flow Nasal Oxygen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baystate Medical Center
Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics
High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of patients with aortic valve disease. TAVR is a less invasive treatment compared to the conventional surgical approach through median sternotomy.
- Trial name
- NCT07059728
- Testing
- Oxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min
- Where
- Spain
- Volunteers
- 452 people
- Sponsor
- Hospital Clinic of Barcelona
Bronchoscopy
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
The purpose of study aims to determine which of the three different oxygenation strategies, including nasal cannula, modified nasopharyngeal cannula, and HFNO groups, is safer in patients undergoing bronchoscopy under sedation.
- Trial name
- NCT05912985
- Testing
- different oxygenation methods
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Ankara City Hospital Bilkent
Hypoxia, Gastric Cancer
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity
Hypoxia is the most common adverse event during gastrointestinal endoscopes sedated with propofol and sufentanil, especially in obese people.
- Conditions
- Hypoxia, Gastric Cancer, Esophagus Cancer, Polyp of Colon
- Trial name
- NCT04500392
- Testing
- High-flow nasal cannula oxygenation, Regular nasal cannula
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Desaturation
Effect of High Flow Nasal Cannula on Oxygenation During Urodynamic Study in Pediatric Population
To evaluate the effect of high flow nasal cannula for prevention of hypoxia during deep sedation in pediatric population
- Trial name
- NCT04152733
- Testing
- High flow nasal cannula
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Seoul National University Hospital
High-flow Nasal Cannula, Children
Application of HFNC for the Prevention of Hypoxemia During Perioperative Anesthetic-induced Intubation in Children: A Randomized Controlled Clinical Trial
Compared with adults, children have higher metabolic needs, and the airway is more likely to collapse. Before tracheal intubation after anesthesia induction, the patient 's spontaneous breathing completely disappears.
- Conditions
- High-flow Nasal Cannula, Children, Pre-oxygenation
- Trial name
- NCT06425406
- Testing
- high-flow nasal cannula
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Hypoxemia, Airway Management
Comparison of High-Flow Nasal Cannula and Tight Face Mask for Maintaining Oxygenation During Rapid Sequence Induction
This prospective randomized controlled trial aims to compare the effectiveness of High-Flow Nasal Cannula (HFNC) versus Tight Face Mask (TFM) in maintaining oxygenation during rapid sequence induction (RSI) for endotracheal…
- Conditions
- Hypoxemia, Airway Management, Endotracheal Intubation, Rapid Sequence Induction
- Trial name
- NCT07723430
- Testing
- High-Flow Nasal Cannula, Tight Face Mask
- Volunteers
- 290 people
- Sponsor
- Khyber Teaching Hospital
Gastric Distention
High Flow Nasal Oxygenation and Gastric Insufflation in Anesthetized Patients
Transnasal humidified rapid-insufflation ventilatory exchange(THRIVE), or also termed high flow nasal oxygenation (HFNO) is a method of supplying heated, humidified high concentrations of oxygen via nasal cavity.
- Trial name
- NCT04629911
- Testing
- THRIVE
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Ajou University School of Medicine
Anesthesia
Evaluation of Different Methods for Preoxygenation
The goal of this randomised cross-over study is to compare pre-oxygenation using a standard nasal cannula to pre-oxygenation using humidified high-flow nasal oxygen and a tight-fitting facemask in adult volunteers with a BMI…
- Trial name
- NCT05839665
- Testing
- Humidified high-flow nasal oxygen, Standard nasal cannula, Facemask
- Where
- 2 sites in Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Malin Jonsson Fagerlund
Coronavirus Infection, COVID
COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss
Prone positioning is an established intervention in mechanically ventilated acute respiratory distress syndrome (ARDS) patients, with demonstrated reductions in mortality.
- Conditions
- Coronavirus Infection, COVID, Severe Acute Respiratory Syndrome, Respiratory Failure
- Trial name
- COVAYDE (NCT04395144)
- Testing
- Awake Prone Positioning, Standard care
- Where
- 5 sites in Canada
- Volunteers
- 13 people
- Sponsor
- Hôpital de Verdun
Morbid Obesity
Nasal High Flow in Bariatric Surgery
High frequency nasal cannula (HFNC) provides an inspiration O2 fraction of 21-1% and it has a minimal dead space and can be well tolerated due to humidified air.
- Trial name
- NCT04048798
- Testing
- Oxygen therapy via HFNC, Oxygen therapy via face mask
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Gastric Cancer, Gastric Ulcer
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients
Obesity is associated with adverse airway events including desaturation during deep sedation. Previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of…
- Conditions
- Gastric Cancer, Gastric Ulcer, Intestinal Cancer, Intestinal Polyps
- Trial name
- NCT05526339
- Testing
- High-flow nasal oxygenation combined with nasopharyngeal airway, Regular nasal cannula combined with nasopharyngeal airway
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Rapid Sequence Induction (RSI), Preoxygenation
High Flow Oxygen in Preoxygenation During Rapid Sequence Induction in Infants and Small Children
Airway management is crucial part of the anaesthesia. There is always a considerable risk of complications or even failure during the anaesthesia induction and airway management.
- Trial name
- PRSIHFO (NCT05846919)
- Testing
- face-mask preoxygenation, HFNOC preoxygenation, HFNOC + face-mask preoxygenation
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Adult Patients, Requiring Intubation
Lung MORphological Modifications Evaluated by Electrical Impedance Tomography During Preoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation (MORPHEIT Study, an Ancillary Study of PREONIV Trial)
Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients. Electrical impedance tomographic evaluation of lung morphology variations according to the…
- Conditions
- Adult Patients, Requiring Intubation, Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200), Patient Covered by French Health Care System
- Trial name
- MORPHEIT (NCT03282331)
- Testing
- Standard oxygenation, High flow nasal oxygenation, noninvasive ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Need for Intubation, Oxygenation Before and During Intubation
Efficacy of High Flow Nasal Cannula Oxygen to Reduce Desaturation During Tracheal Intubation
Tracheal intubation of critically ill patients is associated in the intensive care unit (ICU) with significant complications and morbidity.
- Trial name
- HAPI (NCT01699880)
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Hôpital Louis Mourier
Chest Trauma, High Flow Oxygenation
Management of Moderately Hypoxemic Thoracic Trauma
In France, the average incidence of thoracic trauma is 10,000 to 15,000 each year. These patients are at risk of early and late post traumatic respiratory complications as follows: pneumonia, Acute Respiratory Distress Syndrome…
- Trial name
- TrOMaTho (NCT03997630)
- Testing
- High flow Oxygenation, Standard oxygen
- Where
- 18 sites in France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Brest