Clinical trials: High Risk Cancer
High Grade Upper Tract Urothelial Carcinoma
Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer
This phase II trial studies how well giving chemotherapy before surgery works in treating patients with aggressive upper urinary tract cancer.
- Trial name
- NCT02412670
- Testing
- Methotrexate, Vinblastine, Doxorubicin
- Where
- 134 sites in United States
- Volunteers
- 36 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Cancer, Metastatic Cancer
Treatment of Cancer With Immune Checkpoint Inhibition Therapy Boosted by High Intensity Focused Ultrasound Histotripsy
This phase 1 clinical trial aims to evaluate the safety, tolerability and feasibility of combination treatment of High Intensity Focused Ultrasound Histotripsy (HIFU-HT) and immune checkpoint inhibitors (ICI) in adult patients…
- Trial name
- iFOCUS (NCT06524570)
- Testing
- HIFU-HT, ICI
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- UMC Utrecht
Lymphoma, B-Cell, Leukemia, B-cell
XLCART001 Treatment in Relapsed/Refractory/High-risk B-cell Malignancy Subjects
The trial is a single arm, single-center, non-randomized clinical trial which is designed to evaluate the efficacy and safety of XLCART001 in treatment of relapsed/refractory/high-risk B-cell malignancy subjects
- Trial name
- NCT03598179
- Testing
- chimeric antigen receptor T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Multiple Myeloma
Daratumumab, VELCADE (Bortezomib), Lenalidomide and Dexamethasone Compared to VELCADE, Lenalidomide and Dexamethasone in Subjects With Previously Untreated Multiple Myeloma
Background of the study: The combination of daratumumab with VRd is anticipated to further improve response rates in patients and may lead to improved long-term outcomes in newly diagnosed patients with multiple myeloma.
- Trial name
- Perseus (NCT03710603)
- Testing
- Daratumumab, Velcade, Lenalidomide
- Where
- 13 sites in Australia, Belgium and 11 more
- Volunteers
- 709 people
- Sponsor
- Stichting European Myeloma Network
Neoplasms, Breast
A Study to Examine the Effects of Low and High-fat Meals on Orally Administered Lapatinib in Metastatic ErbB2 Positive Breast Cancer Patients
This study will be a randomized 3-treatment, cross-over study to evaluate the bioavailability of lapatinib administered after a high or low-fat meal.
- Trial name
- NCT00821054
- Testing
- Lapatinib
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Platinum-resistant Ovarian Cancer
A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer
This is phase 2 single arm study evaluating the safety and preliminary efficacy of M-CENK adoptive cell therapy and fixed dose of N-803 in combination with gemcitabine in participants with platinum-resistant high-grade ovarian…
- Trial name
- NCT06710288
- Testing
- Gemcitabine, N-803, M-CENK
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- ImmunityBio, Inc.
Breast Cancer Female, Metastases Breast
MicroRNAs and Prognosis in Breast Cancer
Mono-centric, observational retrospective and prospective study, designed for breast cancer patients to identify novel miRNA based biomarker able to predict metastases development in breast cancer patients.
- Trial name
- BREMIR (NCT06555354)
- Testing
- miRNA targeted analysis on breast cancer tissues, miRNA targeted analysis on plasma samples, miRNA profiling of breast cancer tissues
- Where
- Italy
- Volunteers
- 1,432 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Breast Cancer
Is Lipid Mapping an Effective Early Detection Tool for Breast Cancer in High-risk Populations?
This study aims to investigate if lipid composition mapping using magnetic resonance imaging could improve early and accurate cancer detection in genetic mutation carriers at high risk of breast cancer.
- Trial name
- NCT03949946
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Ewing's Family Tumors, Renal Tumors
Auto Transplant for High Risk or Relapsed Solid or CNS Tumors
This is a standard of care treatment guideline for high risk or relapsed solid tumors or CNS tumors consisting of a busulfan, melphalan, thiotepa conditioning (for solid tumors) or carboplatin and thiotepa conditioning (for CNS…
- Conditions
- Ewing's Family Tumors, Renal Tumors, Hepatoblastoma, Rhabdomyosarcoma
- Trial name
- NCT01505569
- Testing
- Ifosfamide, Etoposide, Mesna
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Adenocarcinoma of the Prostate
Evaluation of the Efficacy and the Safety of a Stereotaxic Prostatic Radiotherapy Delivered With Linac MRI, in Patients With Prostate Adenocarcinoma
Stereotaxic prostatic radiotherapy on Linac MRI, with monitoring of movements of the pelvic organs per fraction on the prostate in real time, in 4 sessions, with integrated boost on the index tumor (if it is visible on the…
- Trial name
- STEREO-RML (NCT04909294)
- Testing
- Stereotactic Radiotherapy with Linac MRI
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Georges Francois Leclerc
Bone Fracture, Glucose, High Blood
Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer
Breast cancer is the most common cancer type in European women. Patients treated for early non-metastatic breast cancer comprise a growing group of survivors due to early diagnosis and improved treatment.
- Conditions
- Bone Fracture, Glucose, High Blood, Insulin Resistance, Blood Pressure, High
- Trial name
- NCT03784651
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Large B-cell Lymphoma, Relapsed Non-Hodgkin Lymphoma
Emapalumab Prevention of CAR-T Cell Associated Toxicities
This research study involves assessing the impact of emapalumab as preventative management of CAR-T related cytokine release syndrome in participants with Non-Hodgkin's lymphoma (NHL).
- Conditions
- Large B-cell Lymphoma, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
- Trial name
- NCT06550141
- Testing
- Emapalumab, Cyclophosphamide, Fludarabine Phosphate
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Marcela V. Maus, M.D.,Ph.D.
Breast Cancer, Prostate Cancer
Physical Activities by Technology Help (PATH)
PATH is a research study for cancer survivors to help participants to become more active. Studies suggested an association between inactivity and cancer.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- PATH (NCT03212079)
- Testing
- Mycoach Smart Text, MyCoach on Amazon Alexa
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Prostate Cancer
Extended Pelvic Lymph Node Dissection vs. no Pelvic Lymph Node Dissection at Radical Prostatectomy for intermediate-and High-risk Prostate Cancer
For patients with intermediate-risk prostate cancer plus a predicted risk of >5% for positive lymph nodes and with high-risk prostate cancer, international guidelines recommend ePLND along with the RP.
- Trial name
- NCT03921996
- Testing
- Radical prostatectomy (RP) followed by ePLND, Radical prostatectomy (RP) only
- Where
- 11 sites in Switzerland
- Volunteers
- 57 people
- Sponsor
- Swiss Cancer Institute
Breast Cancer
Postmastecomy Internal Mammary Nodal Irradiation for High-risk Breast Cancer Patients
The purpose of this study is to evaluate the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients treated with mastectomy or breast-conserving surgery.
- Trial name
- NCT04320979
- Testing
- internal mammary nodal irradiation, no internal mammary nodal irradiation
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prostate Cancer
PSMA PET/CT vs. mpMRI in Patients With a High Suspicion of Prostate Cancer: a Head to Head, Parallel, Prospective Trial
This is prospective single-arm case-control study designed to compare in parallel PSMA PET/TRUS (trans-rectal or trans-perineal) fusion biopsy ("experimental test") with mpMRI/TRUS fusion prostate biopsy ("standard test") in men…
- Trial name
- PROSPET-BX (NCT05297162)
- Testing
- PSMA PET/TRUS (trans-rectal or trans-perineal) fusion biopsy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Istituto Clinico Humanitas
CNS Tumor, Solid Tumor
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies
The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational…
- Trial name
- NCT03838042
- Testing
- Nivolumab and Entinostat
- Where
- 14 sites in Australia, Austria and 5 more
- Volunteers
- 91 people
- Sponsor
- University Hospital Heidelberg
Glioblastoma, High-Grade Glioma (WHO III-IV)
Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4)
Brain tumors account for 1.35% of all cancers and cause 2.2% of cancer-related deaths. Gliomas are the most common type, comprising 40-90% of central nervous system tumors in different age groups.
- Conditions
- Glioblastoma, High-Grade Glioma (WHO III-IV), Glioblastoma (GBM)
- Trial name
- NCT07488754
- Testing
- Radiation: Local, targeted therapy with alpha emitter [225Ac]Ac-DOTA-SP (TAT)
- Where
- 2 sites in Poland
- Volunteers
- 35 people
- Sponsor
- Medical University of Warsaw
Acute Myeloid Leukaemia, Myelodysplasia
Clofarabine Pre-conditioning With Allogeneic Transplant for Acute Myeloid Leukaemia (AML)
This study has been designed to investigate the safety and feasibility of using a chemotherapy drug, Clofarabine, to reduce the disease burden before a donor transplant, in patients with high risk Acute Myeloid Leukaemia or…
- Trial name
- NCT01422603
- Testing
- Clofarabine
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Neoplasms, Endometrial
A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)
The goal of this study is to evaluate the safety profile of dostarlimab in Indian adults with recurrent or advanced endometrial cancer.
- Trial name
- NCT06897527
- Testing
- Dostarlimab
- Volunteers
- 100 people
- Sponsor
- GlaxoSmithKline
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