Clinical trials: High Risk MSM
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
HIV Infections
PrEP Seguro: Antiretroviral-based HIV Prevention Among Men at High Risk in Mexico
The objective of this R34 application is to prepare for testing innovative user-centered ways to promote PrEP adherence at scale.
- Trial name
- NCT03674983
- Testing
- Conditional Economic Incentive (CEI)
- Where
- Mexico
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Brown University
Infection, Human Immunodeficiency Virus, HIV Infections
Incidence of Human Immunodeficiency Virus-1 (HIV-1) Infection in HIV-1 Uninfected High Risk Men Who Have Sex With Men
Studies to assess the effectiveness of interventions to prevent HIV infection depend upon robust estimates of Baseline HIV incidence rates.
- Trial name
- NCT03310515
- Testing
- Risk reduction counseling, Social harm interview, Computer-Assisted Self Interviewing technique
- Where
- 9 sites in China
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Human Immunodeficiency Virus
Feasibility of Short-Term PrEP Uptake for MSM With Episodic High-Risk for HIV
This study is designed to investigate the acceptability, perceived need and uptake of short-term episodic Pre-Exposure Prophylaxis (PrEP) for HIV prevention among men who have sex with men (MSM).
- Trial name
- NCT02495779
- Testing
- emtricitabine/tenofovir, CBT-based counseling
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- James Egan
HIV/AIDS
Evaluating the Feasibility and Acceptability of Implementing a PrEP Program in PR-CoNCRA (San Juan, Puerto Rico)- Part B
75 subjects at risk for HIV infection (25 high risk MSM and 50 sero-discordant couples) will be recruited. All subjects will receive Truvada for pre-exposure prophylaxis or PrEP, as well as routine medical evaluations during one…
- Trial name
- NCT03120494
- Testing
- Emtricitabine and Tenofovir
- Where
- Puerto Rico
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Puerto Rico Community Network for Clinical Research on AIDS
HIV
Evaluating a Real-Time, Remote Monitoring System for Home-Based HIV Testing
This study explores whether offering follow-up counseling and referral over the phone after using a home-based HIV test increases rates of ever and repeat testing, compared with home-based testing with no follow-up (HBST alone)…
- Trial name
- (eTEST) (NCT02876926)
- Testing
- "Smart" home-based test for HIV, Home-based testing only, Reminder letters for clinic-based testing
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV Infections
A Study Evaluating Implementation Strategies for the Delivery of Cabotegravir in Low and High-Volume PrEP Site in the United States
This is a two-arm study evaluating the impact of two implementation strategy conditions, dynamic implementation and routine implementation on the feasibility of delivering of Cabotegravir PrEP in low and high-volume PrEP sites in…
- Trial name
- PILLAR (NCT05374525)
- Testing
- APRETUDE, Cabotegravir OLI
- Where
- 17 sites in United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Patient Adherence, HIV Seronegativity
CCTG 595: Text Messaging Intervention to Improve Adherence to PrEP in High-risk MSM
CCTG 595 is a controlled, open-label, two-arm, randomized (1:1) clinical demonstration project to determine if the use of a text-message based adherence intervention (iTAB) improves retention and adherence to PrEP compared to…
- Trial name
- NCT01761643
- Testing
- SoC + iTab
- Where
- 4 sites in United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Anal Carcinoma, HIV Infection
Anal Cytology Collection Procedures in Predicting High-Grade Anal Dysplasia in Men Who Have Sex With Men
This clinical trial compares three anal cytology collection procedures (collected at a single visit) in men who have sex with men (MSM).
- Conditions
- Anal Carcinoma, HIV Infection, Human Papillomavirus Infection
- Trial name
- NCT02816879
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
High Risk MSM, HIV Negative
Microbicide Safety and Acceptability in Young Men
After completing a screening evaluation, 280 eligible participants, including 40 sex workers, will be enrolled into Stage 1A of the study during which they will undergo a baseline medical evaluation for both history and presence…
- Conditions
- High Risk MSM, HIV Negative, 18-30 Years of Age
- Trial name
- Project Gel (NCT01283360)
- Testing
- Tenofovir 1% Gel
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- CONRAD
HIV/AIDS
Evaluating the Feasibility and Acceptability of Implementing a PrEP Program in PR-CoNCRA (San Juan, Puerto Rico)- Part A
The target population for this project will be men-who-have-sex-with-men (MSM) at high risk of HIV acquisition
- Trial name
- NCT03116932
- Testing
- PrEP knowledge and acceptability questionnaire
- Where
- Puerto Rico
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Puerto Rico Community Network for Clinical Research on AIDS
Social Anxiety, Sexual Risk
Sexual Confidence: CBT for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative gbMSM
Given the continued high human immunodeficiency virus (HIV) prevalence rates among gay, bisexual, and other men who have sex with men (MSM) in North American cities, there is a critical need for HIV prevention interventions for…
- Conditions
- Social Anxiety, Sexual Risk, HIV
- Trial name
- SC-RCT (NCT04381559)
- Testing
- Cognitive Behavioural Therapy, Applied Relaxation
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Anal HSIL, Anal AIN3
Anal Cancer Prevention in High-Risk Categories of Men Who Have Sex With Men
The incidence of anal cancer is increasing, particularly among high-risk groups such as men who have sex with men (MSM), especially those living with HIV.
- Conditions
- Anal HSIL, Anal AIN3, Anal HPV Infection
- Trial name
- DACaP (NCT07123558)
- Testing
- High resolution anoscopy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
HIV Infections, Syphilis
Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador
The purpose of this observational study is to estimate the number of new HIV infections and the number and variability of antiretroviral-resistant HIV strains among men who have sex with men (MSM).
- Conditions
- HIV Infections, Syphilis, Sexually Transmitted Diseases
- Trial name
- NCT00279331
- Where
- 6 sites in Ecuador, Peru
- Volunteers
- 2,608 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Accelerated PrEP Access for Black MSM and TW
The investigators will pilot-test an accelerated PrEP initiation approach among young high-risk Black/African American (B/AA) men who have sex with men (MSM) and transgender women (YMSM/TW) at the point of care in community…
- Trial name
- NCT04329442
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Substance Abuse, HIV Infections
Mirtazapine to Reduce Methamphetamine Use Among MSM With High-risk HIV Behaviors
Studies demonstrate that methamphetamine (meth) use is associated with high-risk sexual behavior among MSM, putting meth-using MSM at extraordinarily high risk for transmitting or acquiring HIV.
- Trial name
- NCT00497081
- Testing
- mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
HIV Prevention
Evaluation of PrEP-30: a Demonstration Project of Pre-exposure Prophylaxis for MSM and Other High-risk Group Clients at the Thai Red Cross Anonymous Clinic
PrEP-30 is a demonstration project to assess the feasibility of providing oral PrEP to MSM and other individuals at-risk for HIV in Bangkok, Thailand as a service that is funded entirely through user fees.
- Trial name
- PrEP-30 (NCT02437981)
- Testing
- PrEP
- Where
- Thailand
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
HIV Infections, Acquired Immunodeficiency Syndrome
Feasibility of Measuring Immune Resp, Activation in Foreskin/Mucosa in HIV-, Uncircumcised High-HIV-risk MSM, Lima Peru
Rectal and genital sampling in HIV prevention trials permits assessments at the site of HIV entry. Yet the safety and acceptability of circumcision and sigmoidoscopy (and associated abstinence recommendations) are unknown in…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Lentivirus Infections, Retroviridae Infections
- Trial name
- HVTN 914 (NCT02630082)
- Testing
- Circumcision, Flexible sigmoidoscopy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Syphilis
Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM
This pilot study will investigate the feasibility of conducting a large, randomized trial comparing a structural intervention to contingency management to reduce incident syphilis infections in an especially high risk group: HIV+…
- Trial name
- DPMSM (NCT02257658)
- Testing
- Doxycycyline, Incentive
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Los Angeles LGBT Center
HIV, Men
Reducing HIV Risk With High Risk HIV Negative Black MSM-Passport to Wellness
The proposed research study will focus on Black men who have sex with men (BMSM) who are HIV- or unknown status AND have not received HIV testing in over a year or who test irregularly (on 9/21/2016, the protocol was changed to…
- Trial name
- PtW (NCT02932384)
- Testing
- Intervention-Passport and Peer Mentor, Control-Passport Only
- Where
- 2 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science