Clinical trials: High Risk Surgery
Myocardial Infarction, Coronary Revascularization
Transfusion Trigger After Operations in High Cardiac Risk Patients
The goal of the proposed study is to determine whether a liberal transfusion strategy (transfusion trigger at Hb < 10 gm/dl) in Veterans at high cardiac risk who undergo major open vascular and general surgery operations is…
- Conditions
- Myocardial Infarction, Coronary Revascularization, Acute Renal Failure
- Trial name
- TOP (NCT03229941)
- Testing
- Blood Transfusion
- Where
- 16 sites in United States
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pelvic Organ Prolapse, Prolapse of Vaginal Vault After Hysterectomy
VITOM Study: A Randomized, Controlled Trial.
This is research in which students are queried by questionnaires on their satisfaction with and experience with certain educational practices (use of a camera image projecting during a live surgery) or with pre-recorded video.
- Conditions
- Pelvic Organ Prolapse, Prolapse of Vaginal Vault After Hysterectomy, Bulging of Vaginal Wall, Incontinence
- Trial name
- VITOM (NCT03120689)
- Testing
- Live Surgery using VITOM, Live Surgery without VITOM, Video viewing with VITOM
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Oxygen, pH
Comparison of the Effects of High-flow Nasal Cannula Oxygen and Jet Ventilation Techniques
Endoscopic microsurgical procedures of the larynx (direct examination-bx, microlaryngeal resection) require the anesthesiologist and surgeon to work in the same area throughout the procedure, and while ventilation is provided…
- Conditions
- Oxygen, pH, End-tidal Carbon Dioxide
- Trial name
- NCT05746949
- Testing
- oxygenization techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cataract
High-Definition 3D Visualization System for Ophthalmic Surgery
To validate a high-definition (HD) three-dimensional (3D) visualization system in cataract surgery
- Trial name
- NCT02194543
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hypothermia, Postoperative Pain
Optimal Temperature Control in Body Contouring Procedures
The goal of this clinical trial is to compare different strategies for normothermia prevention in patients undergoing body contouring and other Aesthetic Plastic Surgery procedures.
- Conditions
- Hypothermia, Postoperative Pain, Postoperative Nausea, Postoperative Complications
- Trial name
- NCT06238739
- Testing
- Control - Standard Strategies for hypothermia prevention, Fluid warming before infusion and infiltration, Thermal convection blanket by water flow (Blanketrol)
- Where
- Colombia
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Arthritis Knee, Spine Fusion
Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery
The present study is a multi-center randomized prospective non-inferiority trial. The study's primary objective is to compare the coagulation profile upon using two different TXA administration strategies: empirical TXA…
- Conditions
- Arthritis Knee, Spine Fusion, Prostate Cancer, Arthritis of Hip
- Trial name
- NCT05957822
- Testing
- TXA, TEG6
- Where
- South Korea
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Coronary Artery Occlusion
Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery
The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.
- Trial name
- NCT01021163
- Testing
- N-acetylcysteine, saline
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Obesity, Morbid, Obesity
CiNPT for Abdominoplasties in Post-bariatric Patients Study
The overarching goal of this research is to assess whether the post-operative use of closed-incision Negative Pressure Therapy (ciNPT) accelerates healing of surgical wounds, improves surgical outcomes, and reduces the rate of…
- Conditions
- Obesity, Morbid, Obesity, Obesity, Abdominal, Wound
- Trial name
- CAPS (NCT04214236)
- Testing
- ciNPT group, Control group
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
Hypoxia
Oxygen Insufflation in Microlaryngoscopies
The purpose of this project is to evaluate the efficacy of oxygen insufflation (continuous oxygen flow) to keep oxygen saturation (oxygen levels measured with a pulse oximeter [finger device used in medicine]) at 90% or greater…
- Trial name
- NCT04979533
- Testing
- Insufflator oxygen tubing
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
ACL Reconstruction, ACL Repair
Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction.
- Trial name
- NCT07384780
- Testing
- High Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Postoperative Nausea and Vomiting
Midazolam Versus Dexamethasone-ondansetron in Preventing Postoperative Nausea-vomiting for Laparoscopic Surgeries
Postoperative nausea and vomiting(PONV) affects 11 to 60 % of patients undergoing surgery and is a major cause of postoperative morbidity.
- Trial name
- NCT03603119
- Testing
- Normal saline, Midazolam, Dexamethasone, ondansetron
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Obesity, Morbid
The Effect of High Protein Diets on Weight Loss and Lean Muscle Mass in Patients Awaiting Bariatric Surgery
All patients in CMDHB eligible for bariatric surgery are given a weight loss goal prior to surgery. It is unknown what the most effective diet is to lose weight, while still preserving muscle mass.
- Trial name
- NCT02631707
- Testing
- High protein diet
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Delirium
Quetiapine as Prophylaxis for Delirium in CABG
low-dose quetiapine may be effective in preventing delirium in patients. The purpose of this study is to evaluate the efficacy and safety of quetiapine for delirium prophylaxis in cabg
- Trial name
- NCT05801289
- Testing
- Quetiapine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Nausea and Vomiting
Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery
The laparoscopic technique is commonly employed for abdominal gynaecological surgery in women. Postoperative nausea and vomiting (PONV) may occur in 30% of women undergoing gynaecological surgery.
- Trial name
- NCT02666014
- Testing
- Sugammadex, Neostigmine
- Where
- Singapore
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University
Change in Sustained Attention
Attentional Capacity and Clinician Performance
Uncovering the distinct measurements and features that potentially exist in different levels of expertise when performing cardiology-based procedures.
- Trial name
- ACCP (NCT02928796)
- Testing
- Cognitive Stimulus
- Where
- Ireland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University College Cork
Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx
Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors
This pilot clinical trial studies freeze-dried black raspberries (BRB) in preventing oral cancer recurrence in high at-risk Appalachian patients previously treated with surgery for oral cancer.
- Conditions
- Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage I Squamous Cell Carcinoma of the Oropharynx, Stage I Verrucous Carcinoma of the Oral Cavity, Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity
- Trial name
- NCT01504932
- Testing
- BRB Lozenge, Survey Administration, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
High Frenum Attachment
Comparison of Frenotomy and Frenectomy Techniques for Management of High Frenum Attachment in Adults
The goal of this randomized clinical trial is to compare frenotomy to frenectomy surgical techniques in the management of high frenum attachment in adults.
- Trial name
- NCT06331325
- Testing
- Frenotomy, Frenectomy
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Dental Implant Failed
Autogenous Particles Harvesting During Implant Surgery
The aim was to compare the osteoblast activity and osteogenic potential of autogenous bone particles harvested using three different techniques, determine the most advantageous method of collecting autogenous bone particles.
- Trial name
- NCT06240416
- Testing
- Low speed drilling without irrigation, High speed drilling with irrigation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia