Clinical trials: High-Altitude Illness
Acute Mountain Sickness, High Altitude Pulmonary Edema
Sleep and Cerebral Responses to High Altitude
Mechanisms underlying high-altitude intolerance as well as exercise performance limitation in hypoxia still remain to be fully understood.
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- VALLOT 2011 (NCT01565603)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Covid19, SARS-CoV2 Infection
Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
In this study, the investigators will examine the extent to which having suffered coronavirus disease 2019 (COVID19) impacts one's sensibility to hypoxia by means of the 'Richalet test'.
- Conditions
- Covid19, SARS-CoV2 Infection, Hypoxia, Altitude
- Trial name
- NCT05167357
- Testing
- COVID19
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institut de Formation et de Recherche en Médecine de Montagne
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Acute Mountain Sickness
A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent
Acute mountain sickness is a common ailment in people venturing over 2500 m altitude. Pilgrims to high altitudes are at an added risk since they are unaware and they gain height faster than the recommendations.
- Trial name
- NCT01418157
- Testing
- Acetazolamide
- Where
- Nepal
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Effect of High Altitude
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Psychomotor Performance in Lowlanders
Prospective interventional trial in lowlanders evaluating the effect of acute exposure, acclimatization and re-exposure to high altitude on psychomotor vigilance to measure sustained attention.
- Trial name
- NCT02731456
- Testing
- altitude exposure
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Marc Poulin
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Spectrum of Altitude-associated Neurologic Forms of Altitude
NSAID RCT for Prevention of Altitude Sickness
The proposed study is a prospective, randomized, double-blind, placebo-controlled clinical trial evaluating ibuprofen and placebo for the prevention of neurological forms of altitude illness [including high altitude headache…
- Trial name
- NCT01606527
- Testing
- Ibuprofen 600mg orally three times daily
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Naval Health Research Center
High Altitude Pulmonary Edema
Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography
The overall goal of this study is to detect preclinical signs of HAPE by lung ultrasonography and evaluate the effectiveness of acetazolamide at decreasing pulmonary edema by using ultrasound.
- Trial name
- NCT03490916
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vincent Kan
Healthy Adults, High Altitude
Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica
Human milk oligosaccharides (HMOs) are the third-most abundant component in mothers' milk and are an important prebiotic factor for the development of the gut microbiota of infants, promoting the growth of certain beneficial…
- Conditions
- Healthy Adults, High Altitude, Isolation, Social
- Trial name
- NCT06133530
- Testing
- Human milk oligosaccharides, Maltose
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- IU University of Applied Sciences
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
High Altitude Pulmonary Hypertension, Sleep Apnea
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT06489730
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Altitude Intolerance, High-Altitude Illness
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex.
- Trial name
- NCT00202683
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Société Française de Cardiologie
Intermittent Hypoxia
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Trial name
- NCT03588676
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Robert L. Owens
Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia
Before birth, the foramen ovale is a normal opening in the heart that allows blood to flow from the mother to the baby. After birth, this opening usually closes.
- Trial name
- NCT07742540
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Acute Mountain Sickness (AMS)
Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness
This trial is aimed to evaluate the effects of "Wu Zhu Yu Tang" on the prevention of Acute Mountain Sickness(AMS).
- Trial name
- NCT01682551
- Testing
- Chinese Medicine, Acetalozamide
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital