Clinical trials: High-Flow Nasal Cannula
Chronic Respiratory Acidosis
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.
- Trial name
- NCT06970002
- Testing
- Use of NIV during FOB as a respiratory support method, Use of HFNC during FOB as a respiratory support method
- Volunteers
- 210 people
- Sponsor
- Medical University of Silesia
Intubation Intraesophageal
Non Invasive Ventilation Combined to High Flow Nasal Cannula Oxygen for Preoxygenation of Hypoxemic ICU Patients
Tracheal intubation is a challenging procedure in Intensive Care Unit (ICU), associated with severe life threatening complications. To decrease these complications, preoxygenation is recommended.
- Trial name
- OPTINIV (NCT02530957)
- Testing
- Non invasive ventilation + High flow nasal cannula oxygen, Non invasive ventilation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome)
High Flow Nasal Cannula HFNC In Covid-19 Patients
Many non-invasive ventilatory choices are available for COVID-19 patient who are having mild to moderate respiratory distress and their use will decrease the chance of ICU admission, intubation and mechanical ventilation in…
- Trial name
- HFNC19LGH (NCT04560257)
- Testing
- High flow nasal cannula HFNC
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Lahore General Hospital
Hypoxemia During EBUS Bronchoscopy
High - Flow Nasal Cannula Versus Conventional Nasal Cannula During Endobronchial Ultrasound Procedure
EBUS bronchoscopy is performed in most centers under local anesthesia and moderate sedation. Both the bronchoscopy itself and the sedation can lead to decreased ventilation and a drop in oxygen saturation in the body.
- Trial name
- NCT06637280
- Testing
- High - flow nasal cannula, Standard nasal cannula
- Where
- 4 sites in Croatia, Greece and 2 more
- Volunteers
- 150 people
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Neonatal Respiratory Distress
A Comparative Study Between Postextubation of Preterm Infants Into High-Flow Nasal Cannulae V.S Nasal Continuous Positive Airway Pressure
The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants.
- Trial name
- NCT04051762
- Testing
- High flow nasal cannula vs. Nasal continuous positive airway pressure
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ramy Saleh Morsy
Respiratory Failure, Bronchiolitis
Using HFNC in Bronchiolitis
The investigators compared oxygen therapy using the HFNC and diffuser mask (an effective low-flow oxygen delivery system) to treat patients with moderate-to-severe acute bronchiolitis admitted to an intensive care unit (ICU).
- Trial name
- NCT03342781
- Testing
- high flow nasal oxygen therapy, Diffuser oxygen mask
- Volunteers
- 60 people
- Sponsor
- Kayseri Training and Research Hospital
Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula
A Multicentered Study on Efficiency of Noninvasive Ventilation Procedures
Noninvasive ventilation (NIV) is an alternative form of ventilatory support in critical care encompassing different modes of ventilation such as continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP)…
- Conditions
- Noninvasive Positive Pressure Ventilation, High Flow Nasal Cannula, Failure, Respiratory
- Trial name
- SAFE-NIV (NCT03066934)
- Testing
- noninvasive ventilation respiratory support
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 352 people
- Sponsor
- Akdeniz University
Acute Respiratory Failure
External Nasal Dilator and Oxygen Therapy in Respiratory Failure
Acute respiratory failure secondary to bronchiolitis and asthma is one of the most common diagnoses in children admitted to pediatric intensive care unit.
- Trial name
- HFNC (NCT02662387)
- Testing
- External nasal dilator (END), High flow nasal cannula (HFNC)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Loma Linda University
High-altitude Pulmonary Edema
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE).
- Trial name
- NCT07536477
- Testing
- High-flow Nasal Cannula Oxygen Therapy (HFNC)
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Third Military Medical University
Need for Intubation, Oxygenation Before and During Intubation
Efficacy of High Flow Nasal Cannula Oxygen to Reduce Desaturation During Tracheal Intubation
Tracheal intubation of critically ill patients is associated in the intensive care unit (ICU) with significant complications and morbidity.
- Trial name
- HAPI (NCT01699880)
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Hôpital Louis Mourier
Postoperative Atelectasis, Postoperative Pulmonary Complications
HFNC for Postoperative Atelectasis After Laparoscopic Surgery
Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative…
- Trial name
- NCT07676760
- Testing
- High-Flow Nasal Cannula (HFNC), Conventional Oxygen Therapy
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
High Flow Nasal Cannula
Work of Breathing and Oxygen Saturation in Infants Receiving High Flow Nasal Cannula (HFNC)
The purpose of this study is to compare work of breathing on different levels of high flow respiratory support on infants born between 27 and 37 weeks gestation.
- Trial name
- NCT03529994
- Testing
- Enrollment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Validation
Prospective Validation of the ROX Index
We recently described the ROX index, defined as the ratio of SpO2/FIO2 to respiratory rate that outperformed the diagnostic accuracy of the two variables separately.
- Trial name
- NCT02845128
- Where
- 5 sites in France, Spain
- Volunteers
- 191 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
COPD
Open-Label Prospective Study Comparing Long-Term Outcome With or Without HFNC in Patients With Stable Hypercapnic COPD
The aims of the study are to compare long-term one-year outcome with or without AirvoTM in stabile hypercapnic COPD patients, who are non-compliant to NIV after an acute exacerbation of COPD.
- Trial name
- MyAirvo (NCT04840706)
- Testing
- HFNC Airvo, Standard care
- Where
- Finland
- Volunteers
- 3 people
- Sponsor
- Turku University Hospital
Pulmonary Disease, Chronic Obstructive (COPD), Dyspnea
Asymmetric High-Flow Nasal Cannula During Pulmonary Rehabilitation in COPD
This randomized pilot trial evaluated the feasibility and preliminary effects of using asymmetric high-flow nasal cannula (A-HFNC) during exercise-based pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Dyspnea, Exercise Tolerance, Rehabilitation
- Trial name
- A-HFNC-PR (NCT07497230)
- Testing
- Asymmetric High-Flow Nasal Cannula (A-HFNC), Conventional Pulmonary Rehabilitation Program
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de Santiago de Chile
Acute Bronchiolitis
High Flow Nasal Cannula Weaning in Acute Bronchiolitis
The goal of this clinical study is to compared two different strategies to end high flow nasal cannula treatment in acute bronchiolitis.
- Trial name
- NCT06321133
- Testing
- High flow nasal cannula immediate ending, High flow nasal cannula weaning
- Where
- 4 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Kuopio University Hospital
Blunt Thoracic Injury, Lung Ultrasound Score
High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients
This prospective randomized controlled study was conducted in the emergency intensive care units (EICU) of the second affiliated hospital Zhejiang university school of medicine, a large tertiary university hospital in HangZhou…
- Trial name
- NCT03430258
- Testing
- high-flow nasal cannula, Conventional oxygen therapy
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure
The goal of this randomized crossover physiological study is to evaluate the physiologic effects of asymmetrical nasal cannula and conventional nasal cannula in patients with acute respiratory failure.
- Trial name
- NCT06204276
- Testing
- Experimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Siriraj Hospital
Respiratory Rate
Respiratory Rate Measured by Pressure Variation During HFNC
Monitoring the respiratory rate is important during procedural sedation. Several methods of measuring the respiratory rate are available, but most are unreliable and the most reliable method (capnography) is not available during…
- Trial name
- NCT05991843
- Testing
- Instructions of breathing
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital