Clinical trials: High-Risk Cancer
Lung Cancer Screening Program, Artificial Intelligence (AI)
Development of an Artificial Intelligence Model for the Identification and Prevention of Smoking-related Diseases.
The study is an interventional pilot study. The study is designed to be monocentric and it presents additional procedues.
- Trial name
- ARIA (NCT06626178)
- Testing
- Computed tomography (CT) scan low dose, Blood sampling, Tissue sampling (lung)
- Where
- Italy
- Volunteers
- 2,840 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Breast Carcinoma
Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care
This study evaluates patient and provider attitudes about environmental exposure risk assessments into clinical care for female patients at average or high risk for breast cancer and/or diagnosed with early onset breast cancer.
- Trial name
- NCT07690852
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
BRCA1 Mutation Carrier, BRCA2 Mutation Carrier
Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of soy isoflavones supplements may prevent or treat early stage breast cancer.
- Conditions
- BRCA1 Mutation Carrier, BRCA2 Mutation Carrier, Ductal Breast Carcinoma in Situ, Lobular Breast Carcinoma in Situ
- Trial name
- NCT01219075
- Testing
- soy isoflavones, questionnaire administration, magnetic resonance imaging
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Colorectal Cancer
Dendritic Cell Vaccination in Patients With Lynch Syndrome or Colorectal Cancer With MSI
Objectives: In this Radboud University Nijmegen Medical Centre (RUNMC) initiated study our first objective is to investigate toxicity (safety and feasibility) of vaccination with frameshift-derived neoantigen-loaded DC of CRC…
- Trial name
- NCT01885702
- Testing
- DC vaccination
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pancreatic Cancer
PANCREATIC DISEASE COHORT A Registry and Biospecimen Bank to Better Understand Pancreatic Disease
The specific aims of this project are to create a registry, as well as a biospecimen bank for individuals with pancreatic disease (e.g.
- Trial name
- NCT01102556
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT After Esophagectomy
Esophagectomy is most curative treatment to esophageal cancer. However, osteoporosis , which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course…
- Conditions
- Osteoporosis, Sarcopenia, Esophageal Cancer
- Trial name
- NCT05812235
- Testing
- esophagectomy
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Nagasaki University
Lung Carcinoma
Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial
This phase II trial evaluates how a virtually supervised exercise intervention in combination with group counseling affects inflammation and the bacterial composition (microbiome) of the gut in smokers who are at high risk for…
- Trial name
- NCT06445192
- Testing
- Best Practice, Biospecimen Collection, Exercise Counseling
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia
Bexarotene in Preventing Breast Cancer in Patients at High Risk for Breast Cancer
This phase I trial studies the side effects and best dose of bexarotene in preventing breast cancer in patients at high risk for breast cancer.
- Conditions
- Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia, Breast Ductal Carcinoma In Situ, Breast Lobular Carcinoma In Situ
- Trial name
- NCT03323658
- Testing
- Bexarotene, Questionnaire Administration
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Neoplasms
Chest Imaging of Lung Nodule(s) Under High-frequency Non-invasive Ventilation (HF-NIV)
Imaging of chest disorders is mainly achieved by using computed tomography. This is especially the case for detection, morphologic assessment and followup of pulmonary nodules.
- Trial name
- NCT03553368
- Testing
- HF-NIV-MR, HF-NIV-PET, MR
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
High-grade Glioma
Nurse-led Family and Network Consultations
Patients diagnosed with high-grade gliomas (HGG) experience a complex symptom burden including high-levels concerns. As a consequence to this life-threatening disease, the rely on close contact with a specialized…
- Trial name
- CARES (NCT03458312)
- Testing
- Family and Network Consultations
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Myeloid Leukemia
Study of Allogeneic Double Negative T Cells (DNT-UHN-1) in Patients With High Risk Acute Myeloid Leukemia
This study aims to determine the safety and toxicity of incremental doses of Double Negative T (DNT) cells in human subjects with high risk acute myeloid leukemia (AML).
- Trial name
- NCT03027102
- Testing
- DNT cells
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Breast Cancer Female
High Physical Activity During a Weight Loss Intervention for Breast Cancer Survivors and High Risk Women
The purpose of this second pilot study is to extend the feasibility demonstrated in NCT02963740 that the intervention achieves high levels of moderate to vigorous physical activity (MVI PA) and modulates risk biomarkers for…
- Trial name
- NCT03270111
- Testing
- Supervised Exercise, Home-based Exercise, Reduced Energy Diet
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Leukemia, Lymphoma
Pharmacokinetic Evaluation of Rasburicase in Patients With Leukemia and/or Lymphoma at High Risk of TLS
Primary 1. To determine the pharmacokinetic (PK) parameters of rasburicase in adult patients with leukemia and/or lymphoma at high risk or potential risk of tumor lysis syndrome (TLS) Secondary 1.
- Conditions
- Leukemia, Lymphoma, Tumor Lysis Syndrome
- Trial name
- NCT00360438
- Testing
- Rasburicase
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Breast Cancer
The Use of a High-frequency Ultrasonic Knife in Breast Cancer Surgery
Background: Lymphatic stasis and seroma formation are common complications of axillary lymphadenectomy in breast cancer surgery.
- Trial name
- UKBC (NCT00996632)
- Testing
- ultrasonic knife (Ultracision®, Ethicon Endo Surgery), conventional diarthermy knife
- Where
- 2 sites in Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Breast Cancer
Weight Loss Plus Omega-3 Fatty Acids or Placebo in High Risk Women
The purpose of this study is to determine if high dose supplementation with the omega-3 fatty acids EPA and DHA, when added to a weight loss program, is well tolerated in the study population and if there is an increase in the…
- Trial name
- NCT02101970
- Testing
- Omega-3 Fatty Acids, Diet and Exercise
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8
Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study
This phase II trial studies how well pembrolizumab works in preventing lung cancer patients with stage I-II non-small cell lung cancer or high-risk pulmonary nodules.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8
- Trial name
- NCT03634241
- Testing
- Pembrolizumab, Quality-of-Life Assessment, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Heavy Smoking
Bronchoscopy Screening for High-risk Population of Lung Cancer With Severe Smoking With Negative LDCT Screen
Based on the previous work of LDCT screening, in order to improve the screening rate of central lung cancer for LDCT negative and severe smokers, the investigators plan to conduct China's first large-scale fluorescent…
- Trial name
- NCT04413669
- Testing
- white light bronchoscopy & autofluorescence bronchoscopy
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Jiayuan Sun
Cervix Cancer, Screen HPV-positive
Uniting Trusted Community Messengers to Improve Access to Cervical Cancer Screening in Rural North Carolina
The purpose of this study is to test the feasibility and acceptability of a multi-level, community-engaged intervention to increase access to cervical cancer screening using human papillomavirus (HPV) self-collection (HPVSC)…
- Trial name
- NCT07294066
- Testing
- Human papilloma virus screening
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Osteoporosis
Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast Density
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. Estrogen can cause the growth of breast cancer cells.
- Trial name
- NCT00114270
- Testing
- letrozole, zoledronic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia