Clinical trials: High-density Stimulation
Mild Cognitive Impairment
Improvement of Memory in Mild Cognitive Impairment
The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory…
- Trial name
- NCT05708001
- Testing
- transcranial alternating current stimulation (tACS), high-density electroencephalography (hdEEG), Montreal Cognitive Assessment (MoCA)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Healthy Volunteers
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Background: Transcranial magnetic stimulation (TMS) uses magnetic pulses to affect brain activity. A type of TMS called theta burst stimulation (TBS) is approved to treat people with major depression.
- Trial name
- NCT06868914
- Testing
- TMS (MagVenture MagPro 100 with MagOption)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Stroke
Clinical, Electrophysiological and E-field Modelling Evidence of High Density Transcranial Direct Current Stimulation in Motor Stroke
The present study aims to investigate the therapeutic potential of a high definition transcranial direct current stimulation protocol, stimulating frontal and cerebellar areas boosting the cognitive and motor recovery of stroke…
- Trial name
- E-brain (NCT05329818)
- Testing
- high definition transcranial direct current stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Xavier Corominas
Spinal Cord Stimulation, High-frequency Stimulation
Direct Comparison of Spinal Cord Stimulator Parameter Settings
(Primary) 1. To compare the clinical effects and side effects of two different stimulation strategies that do not produce any sensory percept (1000 Hz and placebo) on clinical benefit for electrodes implanted for chronic pain as…
- Conditions
- Spinal Cord Stimulation, High-frequency Stimulation, High-density Stimulation
- Trial name
- NCT05283863
- Testing
- High-frequency stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Case Western Reserve University
Upper Limb Amputees
Strategies to Control Robotic Hand Prosthesis Via HD-sEMG and to Restore Sensory Feedback Via TENS
Upper limb amputation still causes severe disability today; prostheses currently on the market are able to restore partially to the amputee the lost functionality.
- Trial name
- NCT06486571
- Testing
- Electromyography recording with HD-sEMG, Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro
Pain, Intractable
High-Density Spinal Cord Stimulation for the Treatment of Chronic Intractable Pain Patients
The purpose of this study is to explore which mode is effective in the management of intractable chronic pain, the high-density stimulation or the conventional stimulation, in patients who undergo SCS implantation after…
- Trial name
- NCT03318172
- Testing
- Spinal Cord Stimulator
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Seoul National University
Healthy Aging
Signal Propagation and Its Relationship to Cognitive Performance in the Aging Human Brain (Focus or Spread)
In the next three decades, the world's population over 60 years old is expected to more than double its size. Even in the absence of an obvious pathology (i.e., healthy aging), advancing age is typically associated with a…
- Trial name
- NCT04361760
- Testing
- single-puls TMS
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
NREM Parasomnias, Sleepwalking
Acoustic Stimulation to Study and Modulate Sleepwalking and Related Arousal Disorders
Disorders of Arousal (DoA)-such as sleepwalking, sleep terrors, and confusional arousals-are common sleep problems that happen during deep, non-dreaming sleep.
- Conditions
- NREM Parasomnias, Sleepwalking, Sleep Terrors, Confusional Arousals
- Trial name
- DoA-CLAS (NCT07754838)
- Testing
- Closed-Loop/Open-Loop Acoustic Stimulation (CLAS)
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anna Castelnovo
Failed Back Surgery Syndrome
High-density in Spinal Cord Stimulation: Virtual Expert Registry
This is a prospective, multi-center, observational follow-up study observing the effectiveness of high density spinal cord stimulation in patients with failed back surgery syndrome patients with back and leg pain.
- Trial name
- Discover (NCT02787265)
- Testing
- spinal cord stimulation
- Where
- Belgium
- Volunteers
- 272 people
- Sponsor
- Universitair Ziekenhuis Brussel
Alzheimer Disease, Memory Loss
Home-based Brain Stimulation for Memory
The proposed project aims to systematically examine the feasibility of remote, caregiver-led tACS for older adults who are vulnerable to memory decline.
- Trial name
- MemStim-home (NCT04783350)
- Testing
- Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Heart Failure, Reduced Ejection Fraction, Vitamin B12 Deficiency
Heart Failure With Reduced Ejection Fraction: Adjuvant Therapy With Neurostimulation and Chlorella Pyrenoidosa (HD-tDCS)
Reduced ejection fraction heart failure (HFrEF) is a complex and multifactorial condition. It is characterized by a decrease in the ability of the left ventricle to eject blood effectively during systole, resulting in an ejection…
- Trial name
- HD-tDCS (NCT06528366)
- Testing
- Chlorella pyrenoidosa, High Definition Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Federal University of Paraíba
Failed Back Surgery Syndrome
EEG Mapping During High Frequency/High Density Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome
This study is an interventional, observatory single center trial investigating the functional connectivity of the electrical brain activity in high frequency/high density spinal cord stimulation in failed back surgery syndrome…
- Trial name
- EEGInspiration (NCT02751216)
- Testing
- EEG recording + pain protocol
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Moens Maarten
Failed Back Surgery Syndrome
StruCtuRal And FuncTional Brain Alterations by Conventional Spinal Cord Stimulation And High DensitY Stimulation
This study is an interventional prospective observatory single center trial, investigating the supraspinal effects of long term conventional SCS (60 Hz) and paresthesia-free high density SCS in failed back surgery syndrome (FBSS)…
- Trial name
- SCRATCHY (NCT02650349)
- Testing
- fMRI
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- Universitair Ziekenhuis Brussel
Neuropathic Pain
A Study to Investigate High-density Spinal Cord Stimulation in Virgin-back Patients
This study will look into the effectiveness of spinal cord stimulation (SCS) in reducing chronic neuropathic pain in patients who have not had previous spinal surgery.
- Trial name
- NCT03716973
- Testing
- High Density Programming
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Barts & The London NHS Trust
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Healthy
Multifocal HD-tDCS and Motor Function
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain…
- Trial name
- NCT06561165
- Testing
- Standard HD-tDCS intervention, Multifocal network targeted HD-tDCS intervention, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease, Essential Tremor
Sensory-specific Peripheral Stimulation for Tremor Management
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons.
- Trial name
- NCT04501133
- Testing
- Peripheral electrical stimulation, Single pulse TMS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Neuropathic Pain, Chronic Pain
Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation
Spinal cord stimulation (SCS) relies on stimulation of pain-relieving pathways in the spinal cord to treat chronic neuropathic pain.
- Trial name
- MOPPStim (NCT03852381)
- Testing
- Spinal Cord Stimulation
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Vegetative State, Minimally Conscious State
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved…
- Conditions
- Vegetative State, Minimally Conscious State, Disorder of Consciousness
- Trial name
- NCT03823508
- Testing
- anodal tDCS
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University of Liege