Clinical trials: High-risk Pregnancy
Hyperkalemia
Tracking Treatment Pathways in Adult Patients With Hyperkalemia.
This study aims to increase the understanding of Hyperkalemia (HK) management, treatment patterns, and the treatment decision-making process for the management of patients with HK over a period of up to 12 months.
- Trial name
- TRACK (NCT05408039)
- Where
- 74 sites in United States, Germany and 3 more
- Volunteers
- 1,331 people
- Sponsor
- AstraZeneca
Ovarian Cancer, Fallopian Tube Cancer
BEACON - ABC in Recurrent Platinum Resistant HGSOC
Epithelial ovarian cancer (EOC) is the ninth most common cause of cancer in Australian women, with an estimated 1500 new diagnoses in Australia in 2015, and remains the seventh most common cause of cancer death in Australian…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- BEACON (NCT03363867)
- Testing
- Atezolizumab, Bevacizumab, Cobimetinib
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
IgA Nephropathy (IgAN)
Exploring the Brain - Gut Microbiota - Kidney Interactive Damage Mechanisms Underlying Cognitive Decline in Patients With IgA Nephropathy Using Ultra-high Field Magnetic Resonance Imaging
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Its progression is often accompanied by cognitive decline, manifesting as multi-dimensional cognitive deficits in areas such as memory, attention…
- Trial name
- NCT07617402
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
High Grade Serous Carcinoma, Ovarian Cancer
Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer
This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases.
- Conditions
- High Grade Serous Carcinoma, Ovarian Cancer, Exosomes, Prognosis
- Trial name
- NCT03738319
- Testing
- Sequencing of miRNA/lncRNA
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Lei Li
Ovarian Cancer, Epithelial, Peritoneal Cancer
Prospective Randomized Trial of Streamlined Genetic Education and Testing for Ovarian Cancer Patients
Current guidelines recommend universal genetic testing for all patients with ovarian, fallopian and peritoneal cancer. The purpose of this trial is to investigate the non-inferiority of streamlined genetics education and testing…
- Conditions
- Ovarian Cancer, Epithelial, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT04537702
- Testing
- Streamlined Education, Traditional Education
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Ovarian Cancer, Fallopian Tube Cancer
Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous or Endometrioid Ovarian Cancer (ARIEL3)
Patients enrolled into this study will be stratified into 3 groups based on gene mutations identified in their tumor tissue. The purpose of this study is to evaluate patient response to maintenance treatment with rucaparib versus…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- ARIEL3 (NCT01968213)
- Testing
- Rucaparib
- Where
- 96 sites in United States, Australia and 9 more
- Volunteers
- 564 people
- Sponsor
- pharmaand GmbH
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to investigate whether percutaneous transluminal renal angioplasty (PTRA) with stent placement of atherosclerotic renal artery stenosis is beneficial in high-risk patients selected according to…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Bladder Cancer
Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBC
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.
- Trial name
- NCT07724886
- Testing
- Conventional Transurethral Resection of Bladder Tumour, Transurethral En Bloc Resection of Bladder Tumour
- Where
- 2 sites in Hong Kong
- Volunteers
- 732 people
- Sponsor
- Chinese University of Hong Kong
D010051, Ovarian Cancer
Validation of ESGO Quality Indicators in Advanced Ovarian Cancer Surgery
This study, organized by the European Society of Gynaecological Oncology (ESGO), evaluates the clinical impact of adherence to ten ESGO-established quality indicators (QIs) in advanced ovarian cancer surgery.
- Conditions
- D010051, Ovarian Cancer, Advanced-stage Ovarian Cancer, FIGO Stages III and IV
- Trial name
- retroESGO ov1 (NCT07567573)
- Testing
- Preoperative Evaluations, Cytoreductive Surgery, Perioperative Management
- Where
- Belgium
- Volunteers
- 11,383 people
- Sponsor
- European Society of Gynaecological Oncology
Renal Insufficiency
Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function
The purpose of this study is to evaluate tirofiban concentration in the blood over a period of 24 hours after tirofiban administration. Subjects with varying degrees of renal insufficiency (i.e.
- Trial name
- NCT01766154
- Testing
- Tirofiban
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medicure
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary
First-line Maintenance Treatment With Fluzoparib Plus Bevacizumab in Advanced BRCA Wild Type Ovarian Cancer
This is an open-label, multi-center Phase II study of fluzoparib combined with bevacizumab for maintenance therapy after first-line platinum-containing chemotherapy in patients with BRCA wild-type advanced ovarian cancer.
- Conditions
- Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, High Grade Endometrioid Ovarian Cancer, Primary Peritoneal Cancer
- Trial name
- NCT06063070
- Testing
- Fluzoparib Capsules, Bevacizumab
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Sun Yat-sen University
Bladder Cancer, Liquid Biopsy
Urinary Tumor DNA-Guided Systemic Immunotherapy for Unresectable Very-High-Risk Non-Muscle-Invasive Bladder Cancer
This study evaluates whether urinary tumor DNA (utDNA) testing, together with clinical, pathologic, and radiographic assessment, can help guide treatment discontinuation and active surveillance in patients with unresectable…
- Conditions
- Bladder Cancer, Liquid Biopsy, Immunotherapy
- Trial name
- NCT07475403
- Testing
- Systemic immunotherapy
- Where
- 3 sites in China
- Volunteers
- 53 people
- Sponsor
- Tianjin Medical University Second Hospital
Preeclampsia
Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Trial
This is a prospective, multicenter, randomized controlled, double-blind trial of three treatment arms: (1) aspirin 75 mg/day vs. (2) aspirin 150 mg/day vs.
- Trial name
- NCT05580523
- Testing
- 75 mg acetylsalicylic acid, 1.5g Metformin, 150 mg acetylsalicylic acid
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Cervical Insufficiency, Cervical Stiffness
Cervical Stiffness Assessment in High-risk Pregnancies for Preterm Birth
Cervical length is usually measured using ultrasound, and if it is shortened, hormone therapy (progesterone) is recommended to reduce the risk of premature birth.
- Trial name
- PilotProPre (NCT07541313)
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Luzerner Kantonsspital
Ovarian Diseases
4K Versus 3D Total Laparoscopic Bilateral Oophorectomy: Tools in Comparison
Evaluate whether the 4K laparoscopic vision system can provide an advantage in performing bilateral oophorectomy procedures for benign conditions carried out by trainee surgeons compared to 3D laparoscopy
- Trial name
- TOLSTOY (NCT06750003)
- Testing
- 3D versus 4K laparoscopic bilateral salpingo-oophorectomy
- Volunteers
- 22 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Acute Coronary Syndrome, Chronic Kidney Diseases
The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated.
- Trial name
- NCT05303441
- Testing
- percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Gestational Diabetes Mellitus, Dietary Habits
A Study of the Intervention of Time-restricted Eating in High-risk Populations of GDM
This is a randomized controlled trial, aiming to investigate whether a time-restricted eating (TRE) can reduce the incidence of gestational diabetes mellitus (GDM) in high-risk pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Dietary Habits, Lifestyle Intervention, Randomized Controlled Study
- Trial name
- NCT06431997
- Testing
- Time-limited eating
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Fudan University
Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications
Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial
Hospitalization in pregnancy and childbirth greatly increases the thromboembolic risk of these patients. The application of a protocol for assessing the risk of VTE reduces mortality and morbidity of these phenomena.
- Conditions
- Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications, Venous Thrombosis, Pulmonary Embolism
- Trial name
- NCT02600260
- Testing
- Enoxaparin, No intervention
- Where
- Brazil
- Volunteers
- 7,212 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bladder Cancer, NMIBC
Age and Bladder Cancer Outcomes After BCG Treatment: A Multicenter Study
This study investigates whether a patient's age affects the outcomes of Bacillus Calmette-Guérin (BCG) treatment for high-grade bladder cancer.
- Trial name
- IATREP_NMIBC (NCT07798479)
- Testing
- Intravesical Bcg
- Volunteers
- 64 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ovarian Cancer, Fallopian Tube Cancers
Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance
The goal of this retrospective observational study is to evaluate the relationship between different dietary patterns (specifically low-carbohydrate diets) and the prognosis of patients with high-grade serous ovarian cancer…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Carcinoma, High-grade Serous Ovarian Cancer
- Trial name
- NCT07269574
- Volunteers
- 600 people
- Sponsor
- Tongji Hospital
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