Clinical trials: Hirschsprung's Disease
Constipation
Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease
Comparison of Circular(Soave)and Heart-shaped Anastomosis in Hirschsprung's disease.
- Trial name
- NCT02234219
- Testing
- Heart-shape anastomosis, Soave anastomosis
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Tongji Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence
Sacral Neuromodulation in Children and Adolescents
The purpose of this study is to assess the efficacy of neuromodulation for treatment of chronic constipation and fecal incontinence in pediatric patients and to evaluate the differences between the invasive vs.
- Conditions
- Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence, Hirschsprung's Disease, Anorectal Malformations
- Trial name
- NCT04713085
- Testing
- Invasive Sacral Neuromodulation, Non-invasive Sacral Neuromodulation
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Hirschsprung's Disease (HD)
Neuropsychological Development and Functional Outcome Sin Children With Hirschsprung Disease at School Age
Hirschsprung's disease (HD) is a rare congenital disease (1:5000) characterized by neonatal functional low bowel obstruction that is caused by aganglionosis of the distal bowel.
- Trial name
- Hirschsprung (NCT03406741)
- Testing
- psychometric evaluation, neuropsychological evaluation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Probiotics, Hirschsprung's Disease Associated Enterocolitis
A Trial on Probiotics in Preventing Hirschsprung's Disease Associated Entercolitis
Enterocolitis(EC) is the most common and serious postoperative complication of Hirschsprung's disease(HD) with high morbidity and mortality.
- Trial name
- NCT01934959
- Testing
- Bifico
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
NEC, Gastroschisis
Neokare Safety and Tolerability Assessment in Neonates With GI Problems
With an increasing body of evidence to support a causal link between drinking milk that contain cow's milk protein (CMP) and the development of gastrointestinal disturbance in infants, many clinicians avoid the use of CMP…
- Conditions
- NEC, Gastroschisis, Intestinal Perforation, Atresia, Intestinal
- Trial name
- NCT05293353
- Testing
- NeoKare Breast Milk Fortifier
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Hirschprung's Disease, Constipation
Comparative Research Between Swenson and Soave Operations for Pediatric Patients Who Have Hirschsprung Disease
Hirschsprung's disease is characterized by a lack of enteric nervous system ganglion cells (aganglionosis) in a variable extent of distal bowel.
- Conditions
- Hirschprung's Disease, Constipation, RECTUM
- Trial name
- NCT07410286
- Testing
- Swenson operation includes resection of the aganglionic segment and anastomosis with full thickness layer above the dentate., Soave procedure: includes resection of the aganglionic segment and anastomosis with submucosal thickness layer above the dentate.
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ahmed Aouf
Hirschsprung Disease, Febrile Urinary Tract Infection (Disorder)
Does Hirschsprung Disease Increase the Risk of Febrile Urinary Tract Infection in Children
Febrile urinary tract infection (FUTIs) are the most common bacterial infections in children under the age of 2 years. They represent 7% of children presenting with fever without a source.
- Trial name
- NCT04837963
- Where
- France
- Volunteers
- 630 people
- Sponsor
- University Hospital, Montpellier
Hirschsprung Disease
Enhanced Recovery After Surgery In Hirschsprung Disease
The study is designed to determine if enhanced recovery after surgery (ERAS) principles could provide benefit for pediatric patients undergoing radical surgery for Hirschsprung's Disease (HD).
- Trial name
- ERASIHD (NCT02776176)
- Testing
- Enhanced Recovery After Surgery Program, Traditional Program
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Weibing Tang
Hirschsprung Disease
Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)
Prospective, randomized, controlled trial to test if post-operative administration of probiotics in HD patients will lead to a reduction in the occurrence of HAEC.
- Trial name
- NCT00630838
- Testing
- VSL#3
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan
Hirschprung's Disease, Hirschsprung Disease
Babies With Enterocolitis - A Study of Faecal Calprotectin in Hirschsprung Disease (The BEACH Study)
Babies with Hirschsprung's Disease are born without normal nerves to the end of their bowel which means they cannot poo properly, and are at high risk of infection of the bowel, called enterocolitis.
- Conditions
- Hirschprung's Disease, Hirschsprung Disease, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- BEACH (NCT06592534)
- Volunteers
- 50 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Hirschsprung Disease
Laparoscopic-Assisted Transanal Pull-Through for Hirschsprung Disease in Pediatric:Short and Intermediate Outcomes of Two Different Techniques
Compare the functional and surgical outcomes of laparoscopic-assisted Swenson-like (LASwL) and laparoscopic-assisted Soave (LASo) pull through in children with HD.
- Trial name
- NCT07186647
- Testing
- laparoscopic-assisted Swenson-like (LASwL), laparoscopic-assisted Soave (LASo)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Hirschsprung Disease, Enterocolitis
Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of…
- Trial name
- HAEC (NCT02193685)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Cedars-Sinai Medical Center
Constipation, Hirschsprung Disease
Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)
Patients undergoing routine rectal suction biopsy will undergo as part of the study an additional Endoscopic mucosal resection. The biopsy results will also be correlated with patient's clinical data including clinical history…
- Trial name
- EDGE (NCT01515501)
- Testing
- Endoscopic mucosal resection (EMR)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Intestinal Obstruction, Gastroschisis
Ostomy in Continuity or Conventional Ileostomy: a Retrospective Multicentric Analysis
Surgical procedures for complex intestinal neonatal and paediatric diseases may require the use of an ostomy, in order to discharge the upper intestine.
- Conditions
- Intestinal Obstruction, Gastroschisis, Enterocolitis, Necrotizing, Hirschsprung Disease
- Trial name
- StomaPed (NCT04213976)
- Testing
- Ileostomy
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Analgesia
Could Peri-anal Block be Effective as Caudal Block in Trans-anal Pull-through Surgery ??.
IN pediatric patient population pain is considered one of the most misunderstood; under diagnosed and under treated medical problems.
- Trial name
- NCT04367818
- Testing
- Peri-anal local anaesthetic infiltration, Caudal anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hirschsprung Disease, Bowel; Perforation, Fetus or Newborn
Risk Factors of Perforated HSCR in Neonates
Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium.
- Trial name
- NCT05044741
- Testing
- Emergency surgical enterostomy
- Volunteers
- 600 people
- Sponsor
- Tongji Hospital
Hirschsprung's Disease Associated Enterocolitis
Neuro-Immune Interactions in the Gut
Hirschsprung's disease (HD) is diagnosed shortly after birth and is characterized by the presence of megacolon. HD is caused when ganglion cells of the enteric nervous system (ENS) in the wall of the large intestine do not…
- Trial name
- NIG (NCT03617640)
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Hirschsprung Disease
Effects of Physiotherapy in Children With Hirschsprung's Disease
The aim of our study is to investigate the effects of physiotherapy in children with Hirschsprung's disease who have bowel symptoms after surgery.
- Trial name
- NCT07156981
- Testing
- Physiotherapy
- Volunteers
- 20 people
- Sponsor
- Ankara Yildirim Beyazıt University