Clinical trials: Hirschsprung Disease
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Hirschsprung's Disease (HD)
Neuropsychological Development and Functional Outcome Sin Children With Hirschsprung Disease at School Age
Hirschsprung's disease (HD) is a rare congenital disease (1:5000) characterized by neonatal functional low bowel obstruction that is caused by aganglionosis of the distal bowel.
- Trial name
- Hirschsprung (NCT03406741)
- Testing
- psychometric evaluation, neuropsychological evaluation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hirschsprung Disease
Comparison of Robot-assisted With Laparoscopic-assisted Modified Soave Procedure for Classical Hirschsprung Disease
Hirschsprung disease (HSCR) is a rare congenital intestinal disease characterized by the absence of ganglion cells in the distal rectum, extending for variable distances into the proximal intestine.The \"pull-through\"…
- Trial name
- RAMS vs LAMS (NCT06197061)
- Testing
- RAMS, LAMS
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zunyi Medical College
Hirschsprung Disease
Laparoscopic-Assisted Transanal Pull-Through for Hirschsprung Disease in Pediatric:Short and Intermediate Outcomes of Two Different Techniques
Compare the functional and surgical outcomes of laparoscopic-assisted Swenson-like (LASwL) and laparoscopic-assisted Soave (LASo) pull through in children with HD.
- Trial name
- NCT07186647
- Testing
- laparoscopic-assisted Swenson-like (LASwL), laparoscopic-assisted Soave (LASo)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Hirschsprung Disease
Induced Pluripotent Stem Cells for Disease Research
The aim of this study is to determine the contribution of genetic factors to the pathogenesis of diseases, including diseases such as Parkinson's disease, Hirschsprung's disease, and autism.
- Trial name
- NCT04476225
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hirschsprung Disease
Registry for Hirschsprung Disease of the BELAPS
Registry for Hirschsprung disease of the BELAPS (Belgian Association of Pediatric Surgery) Protocol Short Title/Acronym / Sponsor name BELAPS Principal Investigator Prof. Dr.
- Trial name
- NCT04622410
- Where
- Belgium
- Volunteers
- 432 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hirschsprung Disease, Enterocolitis
Probiotics and Post-Pullthrough Hirschsprung's Disease-Associated Enterocolitis
This was a prospective case-controlled study investigating the role of probiotics in the management of Hirschsprung-associated enterocolitis (HAEC).
- Conditions
- Hirschsprung Disease, Enterocolitis, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- NCT07098494
- Testing
- Saccharomyces Boulardii Probiotic Supplement
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Aswan University Hospital
Hirschsprung Disease
Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)
Prospective, randomized, controlled trial to test if post-operative administration of probiotics in HD patients will lead to a reduction in the occurrence of HAEC.
- Trial name
- NCT00630838
- Testing
- VSL#3
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan
Nutrition Supporting, Hirschsprung Disease
Nutrition Support for Hirschsprung Disease
A multi-center, prospective,randomized, non-blind, controlled study was conducted to investigate the effects of different pre-operative nutritional support modes on perioperative nutritional status, surgical treatment success…
- Conditions
- Nutrition Supporting, Hirschsprung Disease, Infants, Prospective Study
- Trial name
- NCT04598841
- Testing
- supplement nutritional supporting
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Tongji Hospital
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Bowel Dysfunction, Hirschsprung Disease
Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease
Bowel dysfunction has been proven as the most common complication after pull-through(PT) of Hirschsprung disease(HD) ，which may persist to adulthood and lead to social problems.The reason of bowel dysfunction is complicated and…
- Conditions
- Bowel Dysfunction, Hirschsprung Disease, Risk Factor, Incontinence
- Trial name
- NCT05655845
- Testing
- bowel function score(BFS) questionnaire survey
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Weibing Tang
Children, Anorectal Disorder
3D High Resolution Anorectal Manometry in Children After Surgery for Anorectal Disorders
3D high resolution anorectal manometry (3DHRAM) is the most precise tool to assess function and 3D topographic picture of pressures along the anal canal.
- Conditions
- Children, Anorectal Disorder, Anorectal Atresia, Hirschsprung Disease
- Trial name
- NCT02296008
- Testing
- 3D high resolution anorectal manometry
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Medical University of Warsaw
Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence
Sacral Neuromodulation in Children and Adolescents
The purpose of this study is to assess the efficacy of neuromodulation for treatment of chronic constipation and fecal incontinence in pediatric patients and to evaluate the differences between the invasive vs.
- Conditions
- Chronic Constipation With Overflow, Encopresis With Constipation and Overflow Incontinence, Hirschsprung's Disease, Anorectal Malformations
- Trial name
- NCT04713085
- Testing
- Invasive Sacral Neuromodulation, Non-invasive Sacral Neuromodulation
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Hirschsprung Disease
Hirschsprung Disease Trends in the United States: Analysis of the National Inpatient Sample
Hirschsprung disease (HD) is associated with significant morbidities including long-term bowel dysfunction. The aim of this study was to update national and regional trends in the epidemiology and inpatient care utilization of HD…
- Trial name
- NCT05038345
- Testing
- Pull through surgery
- Where
- United States
- Volunteers
- 2,787 people
- Sponsor
- University of New Mexico
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Hirschprung's Disease, Hirschsprung Disease
Babies With Enterocolitis - A Study of Faecal Calprotectin in Hirschsprung Disease (The BEACH Study)
Babies with Hirschsprung's Disease are born without normal nerves to the end of their bowel which means they cannot poo properly, and are at high risk of infection of the bowel, called enterocolitis.
- Conditions
- Hirschprung's Disease, Hirschsprung Disease, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- BEACH (NCT06592534)
- Volunteers
- 50 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Total Colonic Aganglionosis, Hirschsprung Disease
Robot/Laparoscopic-Assisted Transanal Transection Duhamel Versus Modified Soave Pull-Through for TCA
Total colonic Hirschsprung disease (TCA) is the most severe form of Hirschsprung disease and is commonly managed with neonatal enterostomy followed by delayed definitive pull-through.
- Conditions
- Total Colonic Aganglionosis, Hirschsprung Disease, Duhamel, Soave
- Trial name
- NCT07343622
- Testing
- Transanal Transection Duhamel operation, Modified Soave Pull-Through
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zunyi Medical College
Hirschsprung Disease
Surgical Approach for the Treatment of Hirschsprung Disease Using the Swenson Technique (SMILES)
Hirschsprung disease (HD) is a rare congenital disorder of the enteric nervous system, affecting approximately 1 in 5,000 live births.
- Trial name
- SMILES (NCT07468565)
- Testing
- transanal or laparoscopy assisted Swenson coloanal pullthrough
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
Hirschsprung Disease, Anorectal Malformations
Feasibility of Use of Indocyanine Green in Pediatric Colorectal Surgery
Hirschsprung's Disease (HD) and anorectal malformations (ARM) are both paediatric diseases of the colon and rectum. Both of these conditions require surgery in order to correct them, frequently needing sections of the bowel to be…
- Trial name
- NCT04904081
- Testing
- Indocyanine green
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's