Clinical trials: Hormone Replacement
Estrogen Replacement Therapy
Study Comparing Bioavailability of 3 New Formulations of Premarin/MPA With Premarin/MPA (PREMPRO) Reference Formulation
This study will compare the bioavailabity of three new investigational combination formulations of Premarin and medroxyprogesterone acetate (MPA) with a currently marketed formulation of Premarin and MPA, Prempro™.
- Trial name
- NCT00401219
- Testing
- conjugated estrogens/progestin (MPA)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Infertility
Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients
The purpose of this study is to compare the natural cycle (without any medication) with the well-established artificial cycle in an egg donation program.
- Trial name
- NCT01353846
- Testing
- observation natural cycle, Agonist GnRH; estradiol Valerate; progesterone
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Tobacco Use Disorder
Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
Nicotine is one of the most widely abused substances in the United States. Nicotine replacement therapy (NRT) is currently an effective treatment for nicotine dependence; however, even with NRT most people fail at quitting…
- Trial name
- NCT00258479
- Testing
- ModafinilNicotine Replacement Therapy, Modafinil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Catherine Martin, MD
Nocturia
Effect of Hormonal Replacement Therapy on Nocturia in Postmenopausal Women
Aim of this study was to observe The study was adjusted in two parts: PART 1 is a crossectional study in which the prevalance, risk factors and etiology of nocturia among postmenopausal women is assessed.
- Trial name
- HARALD (NCT04433897)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Smoking Cessation
Comparing the Effectiveness of Combined NRT With Single NRT in Primary Care Clinics in Hong Kong
The prevalence of cigarette smoking has dropped to 10% in Hong Kong (HK) in 2017, however, smoking still kills 5700 persons per year.
- Trial name
- NCT03836560
- Testing
- Nicotine patch, Nicotine gum
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Arteriosclerosis, Acute Myocardial Infarction
Menopause Related Influences on Leukocyte Distribution, Monocyte Function and Platelet Reactivity
Women and men show marked differences in cardiovascular risk profile and outcome. Women experience fewer cardiovascular events than men before menopause, but this relationship seems to reverse at menopause.
- Conditions
- Arteriosclerosis, Acute Myocardial Infarction, Cardiovascular Events, Menopause
- Trial name
- NCT05985447
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Flow-mediated Dilation Evaluation of the Brachial Artery
Vascular Effect of Estradiol Valerate Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery
The aim of this study is to evaluate the vascular effects of estradiol valerate on climacteric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to placebo.
- Trial name
- VEDILA (NCT02161614)
- Testing
- Estradiol valerate
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Transgender Persons, Hormone Replacement Therapy
Trans & Non-binary Reference Intervals While on Hormone Therapy Study
This study will find out what the reference intervals are for common blood tests in transgender people taking hormone therapy. Reference intervals help doctors interpret blood test results.
- Conditions
- Transgender Persons, Hormone Replacement Therapy, Reference Values
- Trial name
- TransRIHTS (NCT04478760)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Arthralgia, Menopause
The MUSE Study for Menopausal Arthralgia
The investigators plan to conduct a pilot 4-arm, randomized study comprising the following interventions: muscle strengthening exercises (MSE) alone, estrogen therapy (ET) alone, and a combination of MSE and ET, compared to usual…
- Conditions
- Arthralgia, Menopause, Perimenopausal Disorder, Joint Pain
- Trial name
- MUSE (NCT06530459)
- Testing
- Menopausal hormone therapy, Exercise training, Menopausal hormone therapy + exercise training
- Where
- Singapore
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Nicotine Replacement Therapy
A Study of Blood Levels of Nicotine Following an Electronic Cigarette
The purpose of this study is to assess the amount of nicotine that is absorbed into the blood stream following the use of a new Electronic Cigarette device called the CN electronic cigarette.
- Trial name
- NCT02794220
- Testing
- CN electronic cigarette 10 mg, CN electronic cigarette 15 mg, Nicorette Inhalator 15 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Menopause, Thrombophilia
Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal Women
The purpose of this study is to determine if Femeralle (DT56a) has an effect on the coagulation system, measured by platelet adhesion and aggregation, of normal and thrombophilic postmenopausal women.
- Trial name
- NCT00883272
- Testing
- DT56a (Femarelle) [Se-cure pharmaceuticals, Dalton, Israel]
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Endometriosis, Fibroids
Evaluating Tibolone Add-back in Patients With Endometriosis and Fibroids
While there are many medical options for managing endometriosis and fibroids, GnRH-agonist (GnRH-a) therapy remains a very common method of treating these complex conditions.
- Trial name
- eTAPE (NCT05568940)
- Testing
- Tibolone 2.5 Mg Oral Tablet
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Qualitative, Nicotine Replacement Therapy
Experiences of Pregnant Women Who Use NRT in Pregnancy as Part of a Quit Attempt
This study is largely a qualitative study with a small survey component. The aim of the survey would be to gain a quantitative perspective of how women use NRT after this has been prescribed by stop smoking services (SSS).
- Conditions
- Qualitative, Nicotine Replacement Therapy, Pregnancy
- Trial name
- NCT02125370
- Testing
- Qualitative and survey
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Smoking Cessation, Tobacco Use Cessation
Interactive Communication Technologies and Nicotine Replacement Therapy Sampling for Smokers
Brief advice combined with active referral to smoking cessation (SC) services increases quitting. We aim to strengthen the effect of combined intervention by using interactive communication technologies and nicotine replacement…
- Trial name
- NCT04001972
- Testing
- Brief advice (AWARD model), NRT-S, IM Apps and Chatbot
- Where
- Hong Kong
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Smoking
Smoking Cessation Program: A Quality Improvement Trial in a Resident-Based Outpatient Clinic
The researchers hypothesize that smoking cessation counseling improves with the implementation of a smoking status assessment data sheet in routine consults.
- Trial name
- NCT00436943
- Testing
- nicotine replacement therapy and bupropion, smoking cessation counseling and referrals
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Smoking Cessation
Nicotine Lozenge Bioequivalence Study
To compare the bio equivalence of new nicotine lozenge formulation with the reference nicotine lozenge so as to deliver the same nicotine blood profile.
- Trial name
- NCT01536704
- Testing
- Nicotine (2 mg), Nicotine (4 mg)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hormone Replacement Therapy
Effects of Estradiol on Menopausal Breast
The purpose of this study is to evaluate the effects on breast in postmenopausal women randomized to either oestradiol in combination with DRSP or E2 in combination with NETA during six months.
- Trial name
- BrAVA (NCT00785317)
- Testing
- Angemin vs Activelle
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Osteopenia, Osteoporosis
Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis
Osteoporosis, a condition in which bones are fragile and break easily, is a major health problem for postmenopausal women. Research studies have shown that both estrogen/progestin replacement therapy (hormone replacement therapy…
- Trial name
- NCT00000430
- Testing
- Alendronate, Estrogen/progestin therapy
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Smoking Cessation
Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers
Background More than 60% of the daily smokers in Hong Kong have never tried and have no intention to quit smoking. About 30.8% of daily smokers attempted to quit but failed.
- Trial name
- NCT03717051
- Testing
- Nicotine replacement therapy (NRT) sampling, Medication counseling
- Where
- Hong Kong
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong