Clinical trials: Hormone Replacement
Metabolic Diseases, Cancer
Transitional Growth Hormone (GH) Use in Growth Hormone Deficient (GHD) Cancer Survivors
Cure rates for childhood malignancies have improved at a remarkable pace.With the increasing cure rate came recognition of the long-term detrimental effects of radiotherapy and chemotherapy, known as "late-effects".
- Trial name
- NCT02629926
- Testing
- GH Replacement (NutropinAq®), No additional treatment
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Mucopolysaccharidosis I, Hurler Syndrome
Study of Aldurazyme® Replacement Therapy in Patients With Mucopolysaccharidosis I (MPS I) Disease
This is a multi-center, open label, study conducted to evaluate the safety of laronidase administered by intravenous drip infusion in Japanese patients with MPS I disease.
- Conditions
- Mucopolysaccharidosis I, Hurler Syndrome, Hurler-Scheie Syndrome, Scheie Syndrome
- Trial name
- NCT00258011
- Testing
- Aldurazyme (Recombinant Human Alpha-L-Iduronidase)
- Where
- 2 sites in Japan
- Volunteers
- 3 people
- Sponsor
- Genzyme, a Sanofi Company
Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches
Electronic Cigarettes and Nicotine Pouches for Smoking Cessation
Pakistan is one of the most vulnerable low- and middle-income countries with 29 million adult active tobacco users. Smoking cessation services are lacking as the tobacco control initiatives have largely failed to address the…
- Conditions
- Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches, Adverse Effect of E-cigarettes and Nicotine Pouches
- Trial name
- NCT05715164
- Testing
- E-cigarettes device plus liquid, Nicotine Pouches, Basic care counseling about smoking cessation
- Where
- Pakistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Alternative Research Initiative
Sly Syndrome, MPS VII
A Study of UX003 Recombinant Human Beta-Glucuronidase (rhGUS) Enzyme Replacement Therapy in Subjects With Mucopolysaccharidosis Type 7, Sly Syndrome (MPS 7)
The primary objective of the study is to evaluate the long-term safety of UX003 in subjects with MPS 7.
- Conditions
- Sly Syndrome, MPS VII, Mucopolysaccharidosis, Mucopolysaccharidosis VII
- Trial name
- NCT02432144
- Testing
- UX003
- Where
- 7 sites in United States, Brazil and 2 more
- Volunteers
- 12 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Cystic Fibrosis (CF), Pancreatic Insufficiency
Safety of Stopping Pancreatic Enzyme Replacement Therapy in Children With Improved Pancreatic Function After Highly Effective Modulator Therapy
The goal of this clinical trial is to evaluate the safety of stopping pancreatic enzyme replacement therapy (PERT) in children with cystic fibrosis (CF) receiving CFTR modulator therapy (CFTRm) who have regained pancreatic…
- Conditions
- Cystic Fibrosis (CF), Pancreatic Insufficiency, Pancreas Disease, Exocrine Pancreatic Insufficiency
- Trial name
- NCT07632768
- Testing
- Discontinuation of Pancreatic Enzyme Replacement Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Indiana University
Hypoplasminogenemia
A Treatment Protocol for Expanded Access Administration of Prometic Plasminogen Due to Closure of Clinical Trial
The clinical trial is no longer enrolling and is currently closing and Prometic will continue to provide Plasminogen (Human) under a treatment protocol to subjects in the United States (US) with hypoplasminogenemia requiring…
- Trial name
- NCT03642691
- Testing
- Ryplazim
- Where
- 3 sites in United States
- Sponsor
- Prometic Biotherapeutics, Inc.
SMA
Single-Dose Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1
Phase 3, open-label, single-arm, single-dose, trial of onasemnogene abeparvovec-xioi (gene replacement therapy) in patients with spinal muscular atrophy (SMA) Type 1 who meet enrollment criteria and are genetically defined by a…
- Trial name
- STRIVE-EU (NCT03461289)
- Testing
- Onasemnogene Abeparvovec-xioi
- Where
- 10 sites in Belgium, France and 2 more
- Volunteers
- 33 people
- Sponsor
- Novartis Gene Therapies
Growth Hormone Deficiency, Pediatric, Endocrine System Diseases
A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency
A 26 week trial of TransCon hGH, a long-acting growth hormone product, administered once-a-week. Approximately 150 children (males and females) with growth hormone deficiency (GHD) will be included.
- Conditions
- Growth Hormone Deficiency, Pediatric, Endocrine System Diseases, Hormone Deficiency, Pituitary Diseases
- Trial name
- NCT03305016
- Testing
- TransCon hGH
- Where
- 24 sites in United States, Australia and 2 more
- Volunteers
- 146 people
- Sponsor
- Ascendis Pharma Endocrinology Division A/S
Menopause, Metabolic Dysfunction Associated Steatotic Liver Disease
COmmencing Menopausal HOrmone Replacement Therapy and the Effect on Metabolic-dysfunction Associated Steatotic Liver Disease: a Pilot Mechanistic Study
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease worldwide, currently affecting approximately 1-in-4 people globally.
- Trial name
- NCT06704516
- Testing
- Menopausal hormone therapy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Oxford
Acute Kidney Injury
A Study of Cell Therapy for Subjects With Acute Kidney Injury Who Are Receiving Continuous Renal Replacement Therapy
The purpose of this study is to assess the safety and tolerability of the investigational product, SBI-101, in subjects with Acute Kidney Injury (AKI) who require continuous renal replacement therapy.
- Trial name
- NCT03015623
- Testing
- SBI-101
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Sentien Biotechnologies, Inc.
Infection During Hemodialysis
Concentration of Ampicillin / Sulbactam and Amoxicillin / Clavulanic Acid in the Blood During Renal Replacement Therapy in Longterm Renal Replacement Therapy Patients
The study will be conducted to investigate the pharmacokinetics of ampicillin / sulbactam and amoxicillin/clavulanic acid during intermittent haemodialysis.
- Trial name
- NCT02007603
- Testing
- Administration of Amoxicillin / clavulanic acid, Ampicillin / sulbactam, Blooddraws for pharmacokinetic profiling
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Vienna
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Hot Flashes
Hormone Replacement Therapy for Hot Flashes and/or Vaginal Symptoms in Postmenopausal Women Receiving Tamoxifen for Breast Cancer
RATIONALE: Hormone replacement therapy may be effective in managing the hot flashes and/or vaginal symptoms in postmenopausal women who are receiving tamoxifen for breast cancer.
- Conditions
- Breast Cancer, Hot Flashes, Menopausal Symptoms
- Trial name
- NCT00026286
- Testing
- conjugated estrogens, medroxyprogesterone
- Where
- 24 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Chronic Kidney Disease
Impact of HemoDiaFIltration on Physical Activity and Self- Reported Outcomes
This is a randomized controlled clinical trial that will analyze the impact of high volume online HDF in comparison to high-flux HD on measured physical activity.
- Trial name
- HDFIT (NCT02787161)
- Testing
- Hemodiafiltration, Hemodialysis
- Where
- 13 sites in Brazil
- Volunteers
- 195 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Vasomotor Symptoms
A Study of Fezolinetant to Treat Hot Flashes in Women Going Through Menopause
This study is for women in menopause who have moderate to severe hot flashes. It is for women who are unable to use hormone replacement therapy (HRT). Menopause, a normal part of life, is the time after a woman's last period.
- Trial name
- Daylight (NCT05033886)
- Testing
- fezolinetant
- Where
- 69 sites in Belgium, Canada and 14 more
- Volunteers
- 453 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Brain Death
Thyroid and Adrenocortical Hormone Replacement in Organ Donors
Brain death inevitably leads to hemodynamic instability and prolonged hypotension that compromises viability of potentially transplantable organs.
- Trial name
- NCT04528797
- Testing
- Levothyroxine, Methylprednisolone
- Volunteers
- 199 people
- Sponsor
- Medical University of South Carolina
Critical Illness, Acute Kidney Injury
Outcomes of Critically Ill Patients With Severe Acute Kidney Injury Requiring Renal Replacement Therapy
This study assess the vital status, renal function and renal recovery of patients admitted to intensive care unit and requiring renal replacement therapy for acute kidney failure.
- Trial name
- PROVEER (NCT02897310)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- University Hospital, Brest
Acute Kidney Injury
Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy
ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.
- Trial name
- IBRIST (NCT06983197)
- Testing
- blood test
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Liver Cirrhosis
Impact of Continuous Renal Replacement Therapy on Systemic Hemodynamics and Lactate Clearance in Critically Ill Cirrhotics With Septic Shock.
Consecutive critically ill cirrhotics with septic shock and AKI who give written informed consent will be included in this prospective study.
- Trial name
- NCT04949178
- Testing
- No intervention
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Need for Renal Replacement Therapy and Anti-infective Therapy Due to Severe Infection
Drugmonitoring of Antiinfective Drugs in Patients Receiving Continous Veno-venous Hemodiafiltration (ABx-CVVHDF)
Approximately 300 patients have to be enrolled in the study. They are followed up until the end of ICU stay. Usually in clinical routine, patients suspected to have infection and simultaneously renal dysfunction making CVVHDF…
- Trial name
- NCT02242721
- Where
- 2 sites in Germany
- Sponsor
- Charite University, Berlin, Germany
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.