Clinical trials: Hormone Replacement
Chronic Kidney Disease, Anemia of Chronic Disease
Effects of Vitamin D Replacement on Hormones Regulating Iron Metabolism in Individuals With Chronic Kidney Disease
The purpose of the study is to learn more about how treatment with vitamin D can affect iron metabolism and blood levels of two hormones that control iron levels, hepcidin and hemojuvelin in people with chronic kidney disease…
- Trial name
- NCT01988116
- Testing
- Oral Calcitriol 0.5 mcg once daily for 6 weeks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Peritoneal Dialysis (PD), Hemodialysis
A Survey for Patients and Caregivers Aiming to Understand and Improve the Care of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis:
Home dialysis is encouraged in Canada and peritoneal dialysis is the most common home dialysis method. However, many patients discontinue peritoneal dialysis, often transferring to hemodialysis.
- Conditions
- Peritoneal Dialysis (PD), Hemodialysis, Kidney Replacement Therapy, Transition
- Trial name
- ULIFT-PD (NCT07437677)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Acute Kidney Injury, Sepsis
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
The goal of this clinical trial is to learn if adding the iron-binding drug MEX-CD1 to dialysis fluid can help remove excess iron in adults with sepsis-associated acute kidney injury (AKI) requiring dialysis who are in the…
- Trial name
- IRON-IC (NCT07236463)
- Testing
- Continuous veino-veinous dialysis with iron-chelator supplemented dialysate
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Iron Deficiency Anemia, Iron Deficiency Anaemia
An Extension Trial to Assess the Safety of Re-dosing of Iron Isomaltoside/Ferric Derisomaltose (Monofer®/Monoferric®)
Evaluate safety and efficacy of intravenous (IV) iron isomaltoside/ferric derisomaltose re-dosing, in subjects who were previously treated with iron isomaltoside/ferric derisomaltose.
- Trial name
- FERWON-EXT (NCT02962648)
- Testing
- Iron isomaltoside/ferric derisomaltose
- Where
- 22 sites in United States
- Volunteers
- 103 people
- Sponsor
- Pharmacosmos A/S
Hypothyroidism
Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients
The aim of the study is to evaluate the peripheral tissue response to the combined administration of levothyroxine (LT4) and liothyronine (LT3) in hypothyroid patients with residual thyroid function virtually absent…
- Trial name
- LEVOLIO (NCT03053115)
- Testing
- Liothyronine, Levothyroxin
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Azienda USL Modena
Short Stature, Idiopathic
Pappalysin 2 (PAPP-A2) Enzyme Replacement
This study evaluates the transfusion of fresh frozen plasma containing the enzyme PAPP-A2 into the a female adult. This female adult has a mutated version of PAPP-A2 that prevents the unbinding of IGF-1 from IGF binding proteins.
- Trial name
- NCT02412943
- Testing
- Fresh Frozen Plasma
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Renal Replacement Therapy, Arteriovenous Fistula
Vein Histology in Arteriovenous Fistulas and Its Effect on Fistula Surgery Success
Patients whose kidneys have failed need to receive dialysis treatment, most commonly with a dialysis machine. In order to be connected to the machine an operation is often performed to join an artery to a vein in the arm.
- Trial name
- NCT01099189
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Kidney Disease
Empowering Patients On Choices for Renal Replacement Therapy (Aim 3) (EPOCH-RRT)
Empowering Patients On Choices for Renal Replacement Therapy (EPOCH-RRT) study seeks to identify factors that matter the most to patients with kidney disease and study how they are impacted by different types of dialysis.
- Trial name
- EPOCH-RRT (NCT02488317)
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Arbor Research Collaborative for Health
Acute Renal Failure
Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF).
This study seeks to determine if increasing the dose of continuous renal replacement therapy (CRRT) reduces 90-day all cause mortality in Intensive Care Unit (ICU) patients with severe acute renal failure (ARF).
- Trial name
- NCT00221013
- Testing
- "augmented" CRRT regimen
- Where
- Australia
- Volunteers
- 1,508 people
- Sponsor
- The George Institute
Menopausal Women
Study of Early Hormone Replacement Therapy on Risk Factors for Sudden Cardiac Death
As an ancillary study to the KEEPS study (see ClinicalTrials.gov Identifier: NCT00154180), the primary purpose is to measure effects of estrogen vs.
- Trial name
- KEEPS (NCT00580775)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yale University
Breast Cancer
Monitoring of Breast Tissue Change Due to Hormone Replacement Therapy in Post-menopausal Women Using OBS
Hormone Replacement Therapy (HRT) is a double edged sword: it can alleviate the effects of menopause for a significant proportion of the female population, however for a smaller proportion, it will induce a significant increase…
- Trial name
- TiBS-HRT (NCT00797199)
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
SMA - Spinal Muscular Atrophy, Gene Therapy
Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1
Phase 3 pivotal US trial studying open-label intravenous administration of onasemnogene abeparvovec-xioi in spinal muscular atrophy (SMA) Type 1 participants.
- Trial name
- STR1VE (NCT03306277)
- Testing
- Onasemnogene Abeparvovec-xioi
- Where
- 16 sites in United States
- Volunteers
- 22 people
- Sponsor
- Novartis Gene Therapies
Pompe Disease Infantile-Onset, Glycogen Storage Disease Type II
Extension Study of Long-term Safety and Efficacy of Myozyme in Patients With Pompe Disease Who Were Previously Enrolled in Genzyme Sponsored Enzyme Replacement Therapy (ERT) Studies
This extension study was to monitor the long-term safety and efficacy of rhGAA treatment in patients with infantile-onset Pompe disease who were previously treated with rhGAA derived from the Synpac cell line
- Trial name
- NCT00763932
- Testing
- Myozyme
- Where
- 8 sites in United States, France and 1 more
- Volunteers
- 7 people
- Sponsor
- Genzyme, a Sanofi Company
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival.
- Trial name
- NCT04103307
- Testing
- Dialysis cooling
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cocaine Dependence
Agonist Replacement Therapy for Cocaine Dependence
Cocaine dependence is a significant public health concern. The proposed research will provide important clinical information regarding the efficacy of agonists replacement therapies for managing cocaine dependence.
- Trial name
- NCT00697138
- Testing
- d-Amphetamine; Atomoxetine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Kentucky
Sly Syndrome, MPS VII
A Study of UX003 Recombinant Human Beta-Glucuronidase (rhGUS) Enzyme Replacement Therapy in Subjects With Mucopolysaccharidosis Type 7, Sly Syndrome (MPS 7)
The primary objective of the study is to evaluate the long-term safety of UX003 in subjects with MPS 7.
- Conditions
- Sly Syndrome, MPS VII, Mucopolysaccharidosis, Mucopolysaccharidosis VII
- Trial name
- NCT02432144
- Testing
- UX003
- Where
- 7 sites in United States, Brazil and 2 more
- Volunteers
- 12 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Hypoactive Sexual Desire Disorder
Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido
This study is designed to evaluate efficacy and safety of a testosterone patch as treatment for low libido in surgically menopausal women who are taking estrogen therapy.
- Trial name
- NCT00331123
- Testing
- Testosterone Transdermal System
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 562 people
- Sponsor
- Warner Chilcott
Critical Ill Patients, Patients Needing Continuous Renal Replacement Therapy
Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients
CRRT patients are generally critical ill patients with unstable conditions, such as low blood pressure,severe SIRS,et al. Acute kidney injury(AKI)is especially prevalent,with even two or more organ failure.
- Trial name
- NCT02355873
- Testing
- AN69ST hemofilter, AN69 hemofilter
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury, Acute Kidney Failure
HEmoFiltration With Citric Acid Anticoagulation
Prospective observational study of all consecutive cardio-vascular surgical patients treated with post-dilution hemofiltration with regional citrate anticoagulation as first-choice anticoagulation method.
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Renal Replacement Therapy, Hemofiltration
- Trial name
- HEFCAA (NCT03836742)
- Testing
- Hemofiltration with regional citrate anticoagulation
- Where
- Poland
- Volunteers
- 54 people
- Sponsor
- Medical University of Gdansk
Mild Cognitive Impairment, Alzheimer's Disease
Hormone and Information Processing Study
The purpose of this study is to examine the effects of testosterone (T) replacement on changes in thinking and memory, as well as mood in older men with mild cognitive impairment (MCI) and low T levels.
- Trial name
- HIP (NCT00539305)
- Testing
- testosterone gel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
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