Clinical trials: Hospitalized COVID-19
COVID 19
BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization
Patients with mild and severe COVID 19 will be randomized 1:1 into two groups: experimental, which will get bromhexine and spironolactone, and control. Patients will get investigated therapy for ten days.
- Trial name
- BISCUIT (NCT04424134)
- Testing
- Bromhexine and Spironolactone, Base therapy
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Tocilizumab for Patients With Cancer and COVID-19 Disease
This phase II expanded access trial will study how well tocilizumab works in reducing the serious symptoms including pneumonitis (severe acute respiratory distress) in patients with cancer and COVID-19.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Pneumonia, Pneumonitis
- Trial name
- NCT04370834
- Testing
- Tocilizumab
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Corona Virus Infection, COVID-19
Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID19
Suspension of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Hospitalized Patients With Coronavirus Infection.
- Trial name
- BRACE-CORONA (NCT04364893)
- Testing
- Suspension or Maintenance of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors
- Where
- Brazil
- Volunteers
- 700 people
- Sponsor
- D'Or Institute for Research and Education
Coronavirus Infection, Covid-19
Pilot Study of Ensifentrine or Placebo Delivered Via pMDI in Hospitalized Patients With COVID-19
This pilot study is being performed to assess the efficacy and safety of inhaled ensifentrine delivered via pMDI compared with a matching placebo in conjunction with standard of care treatments on recovery in patients…
- Conditions
- Coronavirus Infection, Covid-19, SARS-CoV-2
- Trial name
- NCT04527471
- Testing
- Ensifentrine Dose 1
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Verona Pharma Inc
SARS-CoV-2 Acute Respiratory Disease, SARS-CoV2 Infection
Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult Patients
To explore the efficacy of treatment of pulmonary cytokine storm induced by SARS-CoV2 with a monoclonal antibody to IL-2 (Basiliximab) in addition to current standard of care vs current standard of care with the primary efficacy…
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, SARS-CoV2 Infection, Cytokine Storm
- Trial name
- FWCSWG-IL-2 (NCT05013034)
- Testing
- Basiliximab Injection
- Volunteers
- 300 people
- Sponsor
- Fort Worth Clinical Sciences Working Group
COVID-19, Mental Health Impairment
A Study on a Digital Platform for COVID19+ Patients, Designed to Facilitate Communication and Mental-health Care During and After Hospitalization.
This study presents a digital mental-health protocol designed to offer remote, personalized support to former or current COVID-19 patients. A total of 100 subjects will be enrolled.
- Conditions
- COVID-19, Mental Health Impairment, Telemedicine
- Trial name
- DigiCOVID (NCT05231018)
- Testing
- Psychotherapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
SARS-CoV 2, Hospitalisation-Associated Infection
Protein Electrophoresis as a Tool for Complications Prediction in COVID-19 Hospitalised Patients
The inflammation is central in COVID-19 infections. Our aim is to evaluate the clinical value of measuring inflammation by using serum protein electrophoresis (SPE).
- Trial name
- COVELEC (NCT04414059)
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Elsan
SARS-CoV-2
Observational Study of Follow-up of Hospitalized Patients Diagnosed With COVID-19 to Evaluate the Effectiveness of the Drug Treatment Used to Treat This Disease. COVID-19 Registry
The infection caused by COVID19 worldwide makes it necessary to monitor drugs administered for the treatment of patients hospitalized with SARS-CoV-2.
- Trial name
- RegCOVID19 (NCT04347278)
- Testing
- Patients with the treatment agains COVID19
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy.
- Conditions
- Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral
- Trial name
- NCT05123755
- Testing
- AV-001 Injection
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Vasomune Therapeutics, Inc.
COVID19
Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19
This study is a Phase 1, open label, non-randomized, two-arm interventional clinical trial to evaluate the safety and efficacy of Virazole® in hospitalized adult patients who have tested positive for COVID-19 and, as a result…
- Trial name
- NCT04551768
- Testing
- 50 mg/mL Virazole, 100 mg/mL Virazole
- Where
- 4 sites in Greece, Mexico
- Volunteers
- 51 people
- Sponsor
- Bausch Health Americas, Inc.
COVID-19, Mental Health
Impact of a Minimal Psychoeducational Intervention on Anxiety Among Hospitalized COVID-19 Patients in Denmark
Background: There is limited knowledge on the psychological implications of COVID-19 among hospitalized patients and their close relatives.
- Conditions
- COVID-19, Mental Health, Psychoeducation, Anxiety
- Trial name
- PISCA (NCT04351789)
- Testing
- Psychoeducational intervention
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Covid19
Reliability of Standardized Protocol of Ultrasound of the Lungs in Prediction of Severity of Covid-19 Infection
Ultrasound can reliably detect morphologic changes associated with pneumonia. Additionally, protocols were elaborated which unify the investigation procedure and improve the intra- and interrater reliability.
- Trial name
- NCT04513210
- Where
- Poland
- Volunteers
- 94 people
- Sponsor
- Jagiellonian University
Coronavirus Disease 2019, Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2
Study of Varespladib in Patients Hospitalized With Severe COVID-19
This is a 2-part, multi-center, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability, and efficacy of oral varespladib, in addition to standard of care, in patients…
- Trial name
- STAIRS (NCT04969991)
- Testing
- Varespladib
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ophirex, Inc.
COVID-19 Pneumonia
Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of CKD-314
A Double-blind, Multi-center, Multi-regional, Randomized controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of CKD-314 in Hospitalized Adult Patients Diagnosed with COVID-19
- Trial name
- NCT04871646
- Testing
- CKD-314+SOC
- Where
- South Korea
- Volunteers
- 586 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Covid19, Hospitalization
Intensive Dose Tinzaparin in Hospitalized COVID-19 Patients
The primary objective of this study is to evaluate the current management approach with "intermediate" or "therapeutic" doses of tinzaparin for thromboprophylaxis in hospitalized patients, non on ICU organ support, with confirmed…
- Trial name
- INTERACT (NCT05036824)
- Testing
- tinzaparin
- Where
- 7 sites in Greece
- Volunteers
- 300 people
- Sponsor
- University Hospital of Patras
COVID-19 Pneumonia
Efficacy and Safety of Oral Immunotherapy With GcMAF in Hospitalized Patients With COVID-19 Pneumonia
As of August 16, 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for more than 21 294 000 infections and about 760 000 deaths worldwide.
- Trial name
- COral-MAF1 (NCT04845971)
- Testing
- Saisei Maf capsules
- Where
- Italy
- Volunteers
- 97 people
- Sponsor
- Dr. Spadera Lucrezia
Aplastic Anemia, Hematopoietic and Lymphoid Cell Neoplasm
Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization
This phase Ib/II trial studies the side effects and best dose of ibrutinib and how well it works in treating patients with COVID-19 requiring hospitalization.
- Conditions
- Aplastic Anemia, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Monoclonal B-Cell Lymphocytosis
- Trial name
- NCT04439006
- Testing
- Best Practice, Ibrutinib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Jennifer Woyach
Coronavirus Infection, Coronavirus
Convalescent Plasma for Patients With COVID-19
Pilot study of tolerability and efficacy of transfusion of 200mL of convalescent plasma in patients with COVID-19 respiratory disease.
- Conditions
- Coronavirus Infection, Coronavirus, COVID
- Trial name
- NCT04385199
- Testing
- Convalescent plasma
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Henry Ford Health System
SARS-CoV-2, Hypoxia
Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment
Abstract Background: Clinicians in pulmonary critical care medicine and critical care medicine considered dapsone administration to treat SARS-CoV-2 inflammasome.
- Conditions
- SARS-CoV-2, Hypoxia, ARDS
- Trial name
- NCT04918914
- Testing
- Dapsone 100 MG
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hunt Regional Medical Center
Covid19
COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
- Trial name
- NCT04476953
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic