Clinical trials: Human Immunodeficiency Virus Transmission
Trauma, Hiv
Developing a Trauma-focused Intervention for Older Adults Living With HIV
Investigators are adapting the LIFT and REFLECT interventions for older adults living with HIV who have been exposed to childhood sexual abuse.
- Conditions
- Trauma, Hiv, Aging
- Trial name
- NCT05287230
- Testing
- CoSHA (Coping with childhood Sexual Abuse, HIV, and Aging), Control
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of South Carolina
Cachexia, HIV Infections
A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome
To obtain data on the safety of administering megestrol acetate and dronabinol as single agents or in combination to patients with human immunodeficiency virus (HIV)-wasting syndrome.
- Conditions
- Cachexia, HIV Infections, HIV Wasting Syndrome
- Trial name
- NCT00000737
- Testing
- Dronabinol, Megestrol acetate
- Where
- 9 sites in United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus
Testing Strategies for Couple Engagement in PMTCT and Family Health in Kenya
This study will test the efficacy and cost-effectiveness of an interdependence theory-based couples intervention in Kenya that reaches pregnant women and male partners through home visits by male-female pairs of lay health…
- Trial name
- Jamii Bora (NCT03547739)
- Testing
- Home visits, HIV Self-testing
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Inflammation, Pathologic Processes
Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults
This study will collect information about markers of inflammation, blood clotting and blood vessel function in HIV-infected adults and healthy volunteers.
- Trial name
- NCT00776412
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study to Evaluate the Safety and Efficacy of Raltegravir (MK0518) in HIV-Infected Patients Failing Current Antiretroviral Therapies (MK0518-018 EXT2)
This study will investigate the safety and efficacy of raltegravir as a therapy for HIV-infected patients failing current therapy with 3-class antiviral resistance.
- Trial name
- NCT00293267
- Testing
- raltegravir potassium
- Volunteers
- 352 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Trial Comparing Three Strategies of Vaccination Against the Virus of Hepatitis B in HIV Infected Patients
In HIV infected patients, individuals exposed to the virus of Hepatitis B are more susceptible to develop a chronic and severe liver disease with a major risk of cirrhosis and liver cancer.
- Trial name
- VIHVAC-B (NCT00480792)
- Testing
- GenHevac B Pasteur
- Where
- France
- Volunteers
- 437 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Cytomegalovirus Retinitis, HIV Infections
A Pilot Study to Obtain Preliminary Information Regarding the Efficacy and Safety of the Combination of Immune Globulin and Ganciclovir as Compared to Ganciclovir Alone in the Treatment of Sight-Threatening CMV Retinitis in Patients With AIDS
To evaluate whether immune globulin and ganciclovir (DHPG) results in faster initial response as compared to DHPG alone. To evaluate whether immune globulin and DHPG gives longer duration of remission than DHPG alone (i.e.
- Trial name
- NCT00001999
- Testing
- Globulin, Immune, Ganciclovir
- Where
- United States
- Sponsor
- American National Red Cross
HIV Infections
A 14-Day Study of Racivir When Used in Combination in HIV-Infected Males
The purpose of this study is to evaluate Racivir. The safety, most effective dosage, and how the body reacts to Racivir will be studied.
- Trial name
- NCT00040300
- Testing
- Racivir
- Volunteers
- 18 people
- Sponsor
- Pharmasset
Hiv, Physical Inactivity
Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV
The goal of this clinical trial is to examine 3 interventions designed to increase physical activity in older adults with HIV. We will examine 3 potential components of an intervention package: physical activity coaching…
- Conditions
- Hiv, Physical Inactivity, Aging
- Trial name
- HiActivity (NCT05752500)
- Testing
- Cognitive Behavioral Intervention for Physical Activity, Social Support for Physical Activity, Physical Activity Coaching
- Where
- 2 sites in United States
- Volunteers
- 196 people
- Sponsor
- Butler Hospital
Chronic Hepatitis C Infection in HIV Infected Persons, HIV Infections
HRN 004- Peginterferon a-2a Plus Ribavirin for Chronic Hepatitis C Infection in HIV Infected Persons Who Have Failed to Achieve a Sustained Virologic Response Following Previous Interferon Therapy
Objectives: Primary To evaluate the safety, tolerability, and efficacy of Peginterferon a-2a plus Ribavirin for the treatment of chronic hepatitis C (CHC) infection in persons co-infected with human immunodeficiency virus (HIV)…
- Trial name
- NCT00215839
- Testing
- Peginterferon a-2a plus Ribavirin
- Where
- United States
- Sponsor
- Hepatitis Resource Network
HIV Infections
A Comparison of Atazanavir and Nelfinavir, Each in Combination With 2 NRTIs, in Patients Who Have Failed Treatments Without a Protease Inhibitor
The purpose of this study is to compare the atazanavir and nelfinavir (NFV) treatments in their ability to reduce viral load.
- Trial name
- NCT00028067
- Testing
- Atazanavir, Nelfinavir mesylate
- Where
- 62 sites in United States, Canada and 3 more
- Volunteers
- 500 people
- Sponsor
- Bristol-Myers Squibb
HIV Infections, Histoplasmosis
A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS
To test the effectiveness of itraconazole in preventing the recurrence of disseminated histoplasmosis in AIDS patients. Histoplasmosis is a serious opportunistic infection in patients with AIDS.
- Trial name
- NCT00000992
- Testing
- Itraconazole
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Hepatitis C Virus Infection
Digital Community to Improve Health in Rural Areas
The study is a cluster randomized controlled trial developed in counties located in Appalachia and the Midwest. We will prioritize counties from states with high risk for HIV and HCV infection associated with injection drug use.
- Trial name
- NCT05363865
- Testing
- Virtual Community Intervention, Standard of Care
- Where
- United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Infection, Lipodystrophy
Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons With Lipoatrophy
The aim of this study is to evaluate the efficacy for the recovery of peripheral fat of lopinavir/ritonavir in monotherapy versus abacavir/lamivudine and lopinavir/ritonavir in subjects who developed lipoatrophy while receiving…
- Conditions
- HIV Infection, Lipodystrophy, HIV Infections
- Trial name
- KRETA (NCT00865007)
- Testing
- Monotherapy (Lopinavir/ritonavir), Monotherapy (Lopinavir/ritonavir) + ABC/3TC
- Where
- 11 sites in Spain
- Volunteers
- 88 people
- Sponsor
- Fundacion SEIMC-GESIDA
Neuropathic Pain, HIV Neuropathy
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
Distal sensory peripheral neuropathy (DSP) is a chronic, debilitating painful condition affecting quality of life in persons living with HIV.
- Conditions
- Neuropathic Pain, HIV Neuropathy, HIV/AIDS, Pain
- Trial name
- NCT03855111
- Testing
- Standard Acupuncture / Moxibustion, Individualized (Tailored) Active Acupuncture / Moxibustion
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- New York University
HIV Infections
A Study of ddI in Children With AIDS Who Have Not Had Success With Zidovudine
The purpose of this study is to make didanosine (ddI) available to children with AIDS who are clinically deteriorating on zidovudine (AZT) or intolerant to AZT and cannot enter the Phase II ddI programs due to protocol exclusion…
- Trial name
- NCT00002280
- Testing
- Didanosine
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
Sarcoma, Kaposi, HIV Infections
A Phase I/II Study of Recombinant Interleukin-4 in AIDS and Kaposi's Sarcoma
To determine the safety and tolerance of interleukin-4 (IL-4) in patients with AIDS-related Kaposi's sarcoma. To determine the effects of IL-4 on tumor growth in patients with AIDS-related Kaposi's sarcoma.
- Trial name
- NCT00000769
- Testing
- Interleukin-4
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluation of Low-dose Darunavir in a Switch Study
This is a switch study to assess the non-inferiority (in terms of efficacy and safety) of darunavir (boosted with ritonavir, DRV/r 400mg/100mg daily) when compared with lopinavir (boosted with ritonavir, LPV/r total dose…
- Trial name
- DRV (NCT02671383)
- Testing
- Darunavir, Lopinavir
- Where
- South Africa
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Willem Daniel Francois Venter
HIV Infections
Safety and Acceptability of Carraguard® in HIV Positive Women and Men
The study objectives were to assess the mucosal safety of Carraguard® gel when applied vaginally once per day for 14 days by sexually abstinent and sexually active, HIV-positive women; to evaluate the effect of Carraguard® gel on…
- Trial name
- NCT00213005
- Testing
- Carraguard (PC-515)
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- Population Council
HIV/AIDS, Sexual Behavior
Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones
Background: Love, Sex, and Choices (LSC) is a soap opera video series created to reduce HIV sex risk in women. Methods: LSC was compared to text messages in a randomized trial in 238 high-risk mostly Black young urban women.
- Conditions
- HIV/AIDS, Sexual Behavior, Woman's Role, Risk Behavior
- Trial name
- NCT03330522
- Testing
- Love, Sex, & Choices video series, Messages in text
- Where
- United States
- Volunteers
- 295 people
- Sponsor
- Northeastern University
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