Clinical trials: Hydroxyethyl Starch
Subarachnoid Hemorrhage
HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients
The purpose of this study is to determine whether 7.2% NaCl in 6% hydroxyethyl starch will lower intracranial pressure (ICP) in SAH-patients with normal or moderately elevated ICP in a placebo controlled study, and to describe…
- Trial name
- NCT00199706
- Testing
- 7.2% NaCl in 6% hydroxyethyl starch solution
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Adverse Event
Prophylactic Norepinephrine Infusion Combined With Colloid Coloading for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the suitable infusion dose of prophylactic norepinephrine infusion combined with 6% Hydroxyethyl starch (130/0.4) coload for post-spinal anesthesia hypotension in patients undergoing…
- Trial name
- NCT05133817
- Testing
- Normal saline, Norepinephrine (0.025 μg/kg/min), Norepinephrine (0.05 μg/kg/min)
- Where
- China
- Volunteers
- 175 people
- Sponsor
- General Hospital of Ningxia Medical University
Sepsis
Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis
Fluid resuscitation of severe sepsis may consist of natural or artificial colloids or crystalloids. There is no evidence-based support for one type of fluid over another.
- Trial name
- NCT00799916
- Testing
- Resuscitation (Voluven), Resuscitation (Saline)
- Where
- 3 sites in Argentina
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de La Plata
Complications Associated With Artificial Fertilization, Disorder of Endocrine Ovary
Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention
The purpose of this study is to assess whether, in GnRH agonist in vitro fertilization (IVF) cycles, where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch…
- Trial name
- NCT01530490
- Testing
- Cabergoline and Hydroxyethyl Starch, Hydroxyethyl Starch
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital de Cruces
Procedural Bleeding, Delayed Bleeding
A Comparison of Eleview Versus Hetastarch as Injectate for EMR
EMR is a technique used for the removal of flat or sessile neoplasms confined to the superficial layers of the GI tract using a snare.
- Conditions
- Procedural Bleeding, Delayed Bleeding, Post-Polypectomy Syndrome, Post Procedural Complication
- Trial name
- NCT03350217
- Testing
- Eleview, Hetastarch
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Indiana University
Kidney Cancer
Hydroxyethyl Starch and Renal Function After Laparoscopic Nephrectomy
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
- Trial name
- VONE (NCT01486550)
- Testing
- Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9mg/ml
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Regional Hospital Holstebro
Laparoscopy, Tissue Adhesion, Surgery-Induced
The Efficacy and Safety of Medicurtain® in Patients With Total Laparoscopic Hysterectomy (Pivotal Study)
This study was designed to assess the safety and efficacy of MEDICURTAIN. Patients who underwent total laparoscopic hysterectomy were randomly assigned either into Medicurtain® treatment group or non-treatment control group.
- Conditions
- Laparoscopy, Tissue Adhesion, Surgery-Induced, Leiomyoma of the Uterine Body
- Trial name
- NCT04672421
- Testing
- Medicurtain®
- Where
- South Korea
- Volunteers
- 107 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Postoperative Complications
Study to Evaluate the Effect of Hydroxyethyl Starch (HES) in Complications of Patients After Abdominal Surgery
Purpose: To compare the incidence of post-surgery complications and evaluate relevant parameters within 28 days after an operation in HES (130/0.4) and albumin treated groups Study Design: Open-label, active controlled, parallel…
- Trial name
- NCT00308126
- Testing
- Hydroxyethyl Starch 130/0.4 (Voluven)
- Where
- China
- Volunteers
- 624 people
- Sponsor
- Fresenius Kabi
Potential Therapeutic Role
The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning
Aluminum phosphide (ALP) is a widely used fumigant due to its efficiency as pesticides. It is available as tablets of Celphos, Alphos or Quickphos which are known as rice tablets.
- Trial name
- NCT04465539
- Testing
- Hydroxyethyl Starch 130-0.4 60 MG/ML [Voluven], Hydrocortisone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Acute Kidney Injury After Adult Cardiac Surgery
HES and Acute Kidney Injury in Adult Cardiac Surgery
This study retrospectively assess the effect or using balanced hydroxyethyl sctarch (HES) 130/0.4 or a balanced crystalloid solution as a pump prime and for intraoperative fluid therapy on the risk of early acute postoperative…
- Trial name
- NCT02445820
- Testing
- HES, Crystalloid
- Volunteers
- 697 people
- Sponsor
- University of Liege
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green
The goal of this clinical trial is to exploring the use of Mannitol 20% as a solvent to prepare ICG solution, combining with Voluven, forming a hybrid small-large molecular weight solvent for protecting ICG in monomer form and…
- Trial name
- ICGMV (NCT06768268)
- Testing
- Voluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Trauma
Fluid Resuscitation With Hydroxyethyl Starch 130/0.4 in Trauma Patients
Fluid therapy in trauma patients is considered one of the common challenges in daily practice. Both crystalloids and colloids can be used to maintain adequate blood volume and tissue perfusion but there is an ongoing debate as…
- Trial name
- NCT03486600
- Testing
- Fluid Resuscitation
- Volunteers
- 392 people
- Sponsor
- Zagazig University
Parturients, Accidental Puncture of Dura During Anaesthesia
Epidural Hydroxyethyl Starch for Post-Dural Puncture Headache in Parturients
The incidence of accidental dural puncture (ADP) among parturients receiving neuraxial labor analgesia has been reported to range from 1% to 1.5%.
- Conditions
- Parturients, Accidental Puncture of Dura During Anaesthesia, Epidural Filling, Hydroxyethyl Starch
- Trial name
- NCT07914790
- Testing
- Epidural hydroxyethyl starch, No epidural hydroxyethyl starch
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Peking University First Hospital
Hypovolaemia Due to Acute Blood Loss
Safety and Efficacy of 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Patients Undergoing Elective Abdominal Surgery
The aim of the study is to investigate the safety of a 6% HES (Hydroxyethyl Starch) solution (Volulyte 6%) versus an electrolyte solution (Ionolyte) in patients undergoing elective abdominal surgery.
- Trial name
- PHOENICS (NCT03278548)
- Testing
- Volulyte 6%, Ionolyte
- Where
- 61 sites in Austria, Belgium and 8 more
- Volunteers
- 2,289 people
- Sponsor
- Fresenius Kabi
Surgery, Colorectal
Perioperative Colloid vs Crystalloid in Patients Undergoing Colorectal Surgery
The primary purpose of this study is to determine the effect of a balanced 6%hydroxyethyl starch 130/0.4 vs. a balanced crystalloid in colorectal surgery.
- Trial name
- KoKris (NCT01303250)
- Testing
- balanced 6% hydroxyethylstarch 130/0.4, balanced crystalloid
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- University Hospital Muenster
Elective Cardiac Surgery
Safety and Effectiveness of a Balanced 3rd Generation HES Solution (Tetraspan®) After Cardiac Surgery
The purpose of this randomized controlled trial in patients undergoing cardiac surgery is to show that a 3rd generation HES (Hydroxyethyl Starch) solution - Tetraspan® is as good as in terms of safety and effectiveness as the…
- Trial name
- NCT01418521
- Testing
- Balanced hydroxyethyl starch solution, Ringer- albumin
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Rambam Health Care Campus
Fluid Overload, Postoperative Complications
Crystalloids Versus Colloids During Surgery
The purpose of the study is to test whether colloid-based goal-directed intraoperative fluid management leads to less perioperative morbidity compared to crystalloid-based goal-directed intraoperative fluid management.
- Trial name
- CC (NCT00517127)
- Testing
- Lactated Ringer's Solution, Hydroxyethylstarch 6% 130/0.4
- Where
- Austria
- Volunteers
- 1,109 people
- Sponsor
- Medical University of Vienna
Hypovolemia, Hemorrhage
Trial of 6% HES130/0.4
The study shall evaluate the efficacy and safety of two different hydroxyethyl starch solutions (artificial colloids 6% HES130/0.4 and 6% HES70/0.5, Salinhes®) for intra-operative therapy of hypovolemia and maintenance of…
- Trial name
- NCT01010022
- Testing
- 6% hydroxyethyl starch 130/0.4, 6% hydroxyethyl starch 70/0.5 (Salinhes®)
- Where
- 7 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Fresenius Kabi Japan
Sepsis, Severe Sepsis
BaSES Trial: Basel Starch Evaluation in Sepsis
Background: In patients with severe sepsis and septic shock early aggressive volume replacement reduced mortality. Standard infusion therapy consists of crystalloid infusions.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- BaSES (NCT00273728)
- Testing
- hydroxy-ethyl starch (MW 130; 0.4) vs. normal saline
- Where
- 2 sites in Switzerland
- Volunteers
- 231 people
- Sponsor
- University Hospital, Basel, Switzerland
Coagulopathy
ROTEM Assessment of Modern Crystalloid, Hydroxyethyl Starch and Gelatin Effect on Coagulation
Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing.
- Trial name
- NCT03674684
- Testing
- hydroxyethyl starch
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Motol