Clinical trials: Hyperacusis
Noise Exposure, Sleep
De Oorzaak: Citizen Science Project on the Impact of Environmental Noise
"De Oorzaak" is a large-scale citizen science project aiming to assess the impact of environmental sounds on the quality of life.
- Conditions
- Noise Exposure, Sleep, Hyperacusis
- Trial name
- NCT06466668
- Testing
- Sleep study, stress-related biomarkers and microbiome composition will be assessed using saliva samples, Audiological tests
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Tinnitus
Variability of Tinnitus Characterization Tools and Investigation of Audiovisual Integration in Tinnitus Perception
Characterizing the nature and severity of tinnitus in individuals presents a particular challenge. The nature of the sound (loudness and pitch) is not necessarily indicative of the effect on quality of life.
- Trial name
- NCT02717065
- Testing
- Tone, Video
- Where
- United States
- Sponsor
- University of Minnesota
Hyperacusis
Cognitive Behavioral Therapy for Hyperacusis
The main purpose of this study is to investigate whether cognitive behaviour therapy (CBT) can be useful for people suffering from Hyperacusis.
- Trial name
- NCT01321814
- Testing
- Cognitive behavioural therapy
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Linkoeping University
Hyperacusis
Intervention for Reduced Sound Tolerance
Hyperacusis is the intolerance to sound levels that normally are judged acceptably loud to others. The presence of hyperacusis (diagnosed or undiagnosed) can be an important reason why some persons reject amplified sound from…
- Trial name
- NCT00890526
- Testing
- Sound Therapy (Tinnitus Retraining Therapy), Counseling (Tinnitus Retraining Therapy), No Counseling
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama, Tuscaloosa
Prader-Willi Syndrome
Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory
The Polyvagal Theory focuses on how function and structure changed in the vertebrate autonomic nervous system during evolution. The theory is named for the vagus, a major cranial nerve that regulates bodily state.
- Trial name
- NCT03101826
- Testing
- Listening Project Protocol
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Sensory Disorders, Autism
Exposure Therapy for Auditory Sensitivity in Autism
Auditory hyper-reactivity affects up to 66% of children with autism spectrum disorder (ASD) and has been linked to greater stress and anxiety for children and their families.
- Conditions
- Sensory Disorders, Autism, Autism Spectrum Disorder, Autism With High Cognitive Abilities
- Trial name
- NCT03206996
- Testing
- Exposure therapy, Psycho-education, Caregiver education/home program development
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Florida
Misophonia, Emotion Dysregulation
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Misophonia, the inability to tolerate certain repetitive distressing sounds that are common, is gaining, recognition as an impairing condition. It is not a well-understood condition and there are no known treatments.
- Conditions
- Misophonia, Emotion Dysregulation, Sensory Processing Disorder, Auditory Over Responsivity
- Trial name
- MISO-STIM (NCT06333925)
- Testing
- High Frequency Repetitive Transcranial Magnetic Stimulation (HF rTMS), Cognitive Restructuring
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Migraine
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to <18 years with episodic migraine.
- Trial name
- NCT05156398
- Testing
- Rimegepant
- Where
- 93 sites in United States, Canada and 5 more
- Volunteers
- 640 people
- Sponsor
- Pfizer
Hyperacusis
Exploratory Study on the Role of Somatic Modulation in Hyperacusis
This study focuses on patients with a primary complaint of hyperacusis. Hyperacusis has been defined as 'abnormally reduced tolerance to sound' and is commonly associated with tinnitus.
- Trial name
- NCT04693819
- Testing
- Somatic modulation
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Antwerp
Acute Treatment of Migraine
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to < 18 years of age).
- Trial name
- NCT04743141
- Testing
- Rimegepant (PF-07899801)
- Where
- 124 sites in United States, Poland and 1 more
- Volunteers
- 600 people
- Sponsor
- Pfizer
Tinnitus, Subjective, Hyperacusis
Treatment of Tinnitus With Noninvasive Neuromodulation and Listening Therapy
The goal of this study is to use non-invasive transcranial direct current stimulation (tDCS) combined with active listening therapy to treat tinnitus and hyperacusis and related conditions.
- Conditions
- Tinnitus, Subjective, Hyperacusis, Hearing Disorders
- Trial name
- TDCS (NCT04934371)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Migraine
Validation of a Questionnaire for Allodynia in Migraine.
Migraine is very frequent (15% of the general population). During attacks, many subjects with migraine have allodynia (pain induced by normally non-painful stimuli), photophobia (hypersensitivity to light), phonophobia…
- Trial name
- Q-MIGAL (NCT04580641)
- Testing
- Questionnaire
- Where
- 14 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hyperacusis
Role of Exposure in Hyperacusis
This study focuses on patients with a primary complaint of hyperacusis. Hyperacusis has been defined as 'abnormally reduced tolerance to sound'.
- Trial name
- NCT04705246
- Testing
- Psychoeducation
- Volunteers
- 5 people
- Sponsor
- University Hospital, Antwerp
Sensorineural Hearing Loss, Tinnitus
ACEMg Hearing Preservation, Tinnitus and Hyperacusis Relief
ACEMg (Soundbites) is a neuroprotectant supplement designed to block the initiating biological events in the inner ear leading to inner ear hearing loss, sensorineural hearing loss, SNHL, which accounts for more than 90% of all…
- Conditions
- Sensorineural Hearing Loss, Tinnitus, SNHL, Inner Ear Hearing Loss
- Trial name
- OTISRWD (NCT06477354)
- Testing
- ACEMg
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Keep Hearing, Inc.
Hearing Disorders, Hearing Loss
Chronic Electrical Stimulation of the Auditory Cortex for Intractable Tinnitus
The purpose of this study is to determine whether chronic electrical stimulation of the primary auditory cortex is effective in the treatment of chronic, severe and intractable tinnitus
- Conditions
- Hearing Disorders, Hearing Loss, Hyperacusis, Tinnitus
- Trial name
- ACOUSCO (NCT00486577)
- Testing
- significant chronic primary auditory cortex stimulation during the first two weeks, non significant chronic primary auditory cortex stimulation during the first two weeks
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Misophonia, Hyperacusis
Prevalence of Misophonia and Hyperacusis Among Teachers
This study aims to determine the prevalence of hyperacusis and misophonia among teachers and to explore how these auditory sensitivities may relate to occupational stress.
- Trial name
- NCT07527780
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Migraine
Randomized Trial in Adult Participants With Acute Migraines
The purpose of this study is to test the safety and efficacy of BHV-3500 (zavegepant) versus placebo in the acute treatment of moderate or severe migraine.
- Trial name
- NCT04571060
- Testing
- Zavegepant
- Where
- 94 sites in United States
- Volunteers
- 1,978 people
- Sponsor
- Pfizer
Loudness Hyperacusis, Autism Spectrum Disorder (ASD)
Transitional Intervention for Hyperacusis in Autism
The main goal of this clinical trial is to evaluate the effectiveness, benefits, and post-treatment persistence of an intervention for loudness hyperacusis in adults with autism spectrum disorder (ASD).
- Conditions
- Loudness Hyperacusis, Autism Spectrum Disorder (ASD), Hyperacusis
- Trial name
- TIHA (NCT07798297)
- Testing
- Transitional Intervention for Hyperacusis in Autism
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Central Florida
Tinnitus, Hyperacusis
Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis
Neuromonics TInnitus Treatment CALM study is a multi site study of 100 adult subjects with clinically significant disturbing tinnitus to evaluate outcome measures using the FDA cleared Neuromonics treatment after 6, 12, 24 and 36…
- Trial name
- CALM (NCT00730834)
- Testing
- Oasis
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Neuromonics, Inc.