Clinical trials: Hyperaldosteronism
Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia
First-in-human Evaluation of [18F]CETO
Purpose of this clinical phase 1 trial was to determine if para-chloro-2-[18F]fluoroethyletomidate positron emission computed tomography ([18F]CETO-positron emission computed tomography(PET)/computed tomography(CT)) can be used…
- Conditions
- Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Nodular Hyperplasia, Adrenal Cushing Syndrome, Non-Secretory Adrenal Adenoma
- Trial name
- NCT05361083
- Testing
- F18CETO
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Hyperaldosteronism, Hypertension
Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood Pressure
Some patients with high blood pressure can experience an increase of blood pressure by 10 percent or more by taking in salt. These patients are referred to as having "salt-sensitive" (SS) hypertension.
- Trial name
- NCT00001176
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Apparent Mineralocorticoid Excess
An Investigation Into the Effect of Liquorice Ingestion on the Salivary Cortisol to Cortisone Molar Ratio
Aldosterone, the major mineralocorticoid hormone and cortisol, the major glucocorticoid hormone are produced in the adrenal gland.
- Trial name
- NCT02939144
- Testing
- Liquorice
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Apparent Mineralocorticoid Excess Syndrome
Natural History of Apparent Mineralocorticoid Excess Syndrome
Apparent mineralocorticoid excess (AME) is a rare inherited disease that can cause severe high blood pressure and low blood potassium in children and adults. It is caused by abnormal hormone metabolism and can be fatal.
- Trial name
- NCT00474942
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Primary Aldosteronism
The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is a disorder of the adrenal gland causing an autonomous overproduction of mineralocorticoids, leading to arterial hypertension. Although rare, it is the most frequent cause of secondary hypertension.
- Trial name
- NCT02216721
- Where
- Malaysia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
Primary Aldosteronism
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Method
To compare the consistency of 24-hour urinary aldosterone in the diagnosis of primary aldosteronism by oral sodium loading test between the second day method and the third day method
- Trial name
- NCT06750172
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism
Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study
This research focuses on the prevalence of Primary Aldosteronism in the Malaysian adult population.
- Trial name
- MyEndo-PA (NCT02257450)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- International Islamic University Malaysia
Primary Hyperaldosteronism, Electrolyte Disturbance
Tissue K+ in Primary Hyperaldosteronism
Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism.
- Trial name
- NCT04251780
- Testing
- Surgical Treatment of Primary Aldosteronism, Drug treatment of Primary Aldosteronism
- Where
- 2 sites in Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Primary Aldosteronism
Preoperative Supine Time for Adrenal Venous Sampling
This study aim to understand whether the length of preoperative supine time would affect the AVS outcome.
- Trial name
- PSTAVS (NCT05658705)
- Testing
- 15-min supine time, 2-hour supine time
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Aldosteronism
Study on the Application of Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Aldosterone and Renin Activity in the Diagnosis of Primary Aldosteronism by Captopril Test
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is more accurate than the traditional radioimmunoassay method in measuring aldosterone.
- Trial name
- NCT07691801
- Testing
- Captopril inhibition test(CCT)
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Primary Aldosteronism
Multi-omics Studies of Primary Aldosteronism
Primary aldosteronism is a prevalent yet underdiagnosed cause of secondary hypertension, contributing to significant cardiovascular morbidity and renal dysfunction.
- Trial name
- NCT07111351
- Testing
- Without intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Hyperaldosteronism, Hypertension
Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn
WHYSKI is a prospective within-patient observational clinical study designed to test the hypothesis that alterations of Na+, K+, water, and the lympho-angiogenetic transcription factor Tonicity Enhancing Binding Protein (TonEBP)…
- Conditions
- Hyperaldosteronism, Hypertension, Aldosterone-producing Adenoma, Aldosteronism
- Trial name
- WHYSKI (NCT06090617)
- Testing
- Skin Biopsy, Video-laparoscopic adrenalectomy
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Primary Aldosteronism
Study on the Diagnostic Cut-off Point of 24-hour Urinary Aldosterone Measured by Liquid Chromatography-Tandem Mass Spectrometry in the Diagnosis of Primary Aldosteronism in the Oral Sodium Loading Test
Primary aldosteronism (PA) is the most common cause of secondary hypertension. Liquid chromatography - tandem mass spectrometry (LC-MS/MS) is more accurate than the traditional radioimmunoassay in measuring aldosterone.
- Trial name
- NCT07635134
- Testing
- The oral sodium loading test
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Primary Aldosteronism
CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism
This study aimed to prospectively evaluate the utility of C-X-C chemokine receptor type 4 (CXCR4) positron emission tomography (PET) imaging in patients with clinical suspected primary aldosteronism (PA), with postoperative…
- Trial name
- NCT06183554
- Testing
- CXCR4
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiao Chen
Primary Aldosteronism
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.
The objective of this observational study is to utilize the advantages of 68Ga-Pentixafor subtyping diagnosis and the diagnostic ability of 68Ga-FAPI-04 for cardiovascular disease to identify primary aldosterone patients in need…
- Trial name
- NCT06756737
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Primary Hyperaldosteronism, Aldosterone-Producing Adenoma
[18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism
The study was proposed to include 20 patients with clinical suspicion of primary aldosteronism for [18F]AlF-NOTA-pentixather PET/CT imaging and to analyze the specificity and sensitivity of [18F]AlF-NOTA-pentixather PET/CT for…
- Trial name
- NCT05815069
- Testing
- [18F]AlF-NOTA-pentixather PET/CT
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Hypertension is known to be the major risk factor for stroke. The most common cause of secondary hypertension, primary aldosteronism (PA), is characterized by the excessive secretion of aldosterone and is related to hypertension…
- Trial name
- NCT03821571
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aldosterone Disorder, Adrenal Gland Disease
Prospective Phenotyping of Autonomous Aldosterone Secretion
This prospective cohort study will investigate the physiology and progression of autonomous aldosterone secretion.
- Conditions
- Aldosterone Disorder, Adrenal Gland Disease, Blood Pressure
- Trial name
- NCT03484130
- Testing
- Sodium loaded diet, Restricted sodium diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital