Clinical trials: Hyperlactatemia
Sepsis, Sepsis Bacterial
A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor
The overall purpose of this study is to demonstrate the usability of a clinical-grade device in the form of a finger clasp similar to a pulse oximeter for monitoring lactate values, by comparing its performance in reading…
- Conditions
- Sepsis, Sepsis Bacterial, Lactate Blood Increase, Infectious Disease
- Trial name
- NCT04796285
- Testing
- Lab Clasp
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hyperlactatemia, Metabolic Syndrome (MetS)
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
The purpose of this study is to investigate whether the elevated circulating lactate levels of individuals with metabolic syndrome are responsible for their reduced lipolysis and glucose tolerance.
- Conditions
- Hyperlactatemia, Metabolic Syndrome (MetS), Lipolysis, Exercise
- Trial name
- LACTMET (NCT07426172)
- Testing
- hyperlactacidemia, Saline (0.9%, sterile, for infusion)
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ricardo Mora
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Exercise Training, BDNF
Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)
Purpose The purpose of this study is to determine the acute effects of different exercise intensities (low, moderate, high) on brain-derived neurotrophic factor (BDNF) levels, trail making test performance, and perceived…
- Conditions
- Exercise Training, BDNF, Cognitive Functions, Lactate Blood Increase
- Trial name
- Exercise-BDNF (NCT07137611)
- Testing
- Low Exercise, Moderate-Intensity Exercise, HIIT Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aksaray University Training and Research Hospital
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Intracranial Neoplasm, Hyperlactatemia
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies
The investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method…
- Conditions
- Intracranial Neoplasm, Hyperlactatemia, Brain Tumor, Hypoperfusion
- Trial name
- NCT05145049
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Hyperlactatemia
Pilot Testing a Novel Non-invasive Lactate Sensor
To test the efficacy and accuracy of a novel non-invasive lactate sensor in humans undergoing strenuous leg exercise.
- Trial name
- NCT05649358
- Testing
- Lactate sensor (Lactisense)
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Lactate Blood Increase, Exhaustion - Physiological
Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate Responses
The purpose of this study is to assess the health and performance outcomes associated with supplementation of Veillonella atypica.
- Trial name
- VP (NCT05816291)
- Testing
- Time to Exhaustion at velocity at VO2max
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Swimming, Coordination Lack
Swimming Economy in Swimmers and Paraswimmers as a Function of SR(Stroke Rate) and V(Velocity) Manipulations (NePTUNE-3)
The competitive swimming and open water swimming events are scheduled for the 2024 Paris Olympic and Paralympian Games. Generally associated with a non-neglectable number of medals in the last Olympics, swimming performance…
- Conditions
- Swimming, Coordination Lack, Oxygen Consumption, Lactic Acid Blood Increased
- Trial name
- NePTUNE-3 (NCT05011591)
- Testing
- Swimming economy
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Rouen Normandie
Performance Enhancing Product Use, Change, Body Weight
Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International Athletes
This clinical study evaluates the acute effect of glycerol ingestion on performance (power output), weight, urine specific gravity, biochemical (antioxidants and lactate) and metabolic (indirect calorimetry) markers in…
- Conditions
- Performance Enhancing Product Use, Change, Body Weight, Change, Body Temperature, Antioxidative Stress
- Trial name
- NCT05295836
- Testing
- GLYCEROL
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lactate, Healthy
Lactate in the Gut
Lactate is formed naturally in the body in example during physical activity. However, lactate is also formed during food fermentation where certain bacterial strains form lactate. Lactate can also be produced chemically.
- Conditions
- Lactate, Healthy, Hyperlactatemia
- Trial name
- NCT04299815
- Testing
- Oral Sodium Lactate, Intravenous sodium lactate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Blood Lactic Acid Increased, Hip Fractures
Optimal Blood Sampling Site for Point of Care Lactate Assessment
The study was to compare blood Lactate levels between ear lobe and finger against venous forearm blood sample using the electronic hand held lactate device in hip fracture patients with good cognitive function (AMT >/= 7)
- Trial name
- NCT04291989
- Testing
- Optimal Blood Sampling Site for Point of Care Lactate Assessment using the handled Lactate-Pro 2 device
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Exercise-Induced Lactic Acidemia, Lactate Blood Increase
Lithothamnion Species on Blood Lactate During Exhaustive Exercise in Trained Cyclists
Deep ocean mineral water has been shown to improve exercise phenotypes in human and animal models. However, there is yet to be an investigation of Algae species such as Lithothamnion that absorb and concentrate these minerals.
- Trial name
- AAPt (NCT03980678)
- Testing
- Mineral Rich Algae
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Hyperlactatemia
Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?
Lactated Ringer's (LR) solution bolus is commonly administered in the emergency department setting to seriously ill patients. It is also common to obtain blood samples to determine serum lactate levels to aid in the assessment of…
- Trial name
- NCT02950753
- Testing
- Lactated Ringer Solution, Normal Saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Sepsis, Lactate Blood Increase
Blood Lactate Level for Pre-hospital Orientation of Septic Shock
In the pre-hospital setting, the severity assessment of septic shock is essential to decide the optimal initial in-hospital level of care.
- Trial name
- LAPHSUS (NCT03831685)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hôpital Necker-Enfants Malades
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Hyperlactatemia
Effect of Metformin on Lactate Metabolism
The main objective of this study is to evaluate the influence of metformin on lactate metabolism. The main outcome is the lactate production following an exogenous lactate overload in healthy male subjects without metformin and…
- Trial name
- NCT00390273
- Testing
- Metformin
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe