Clinical trials: Hyperpigmentation
Hyperpigmentation; Melanin, Laser-Induced Hyperpigmentation
Laser-Assisted Gingival Depigmentation
This randomized clinical trial evaluated the recurrence rates of physiological gingival pigments during 24 months follow-up and the patient perceptions after the ablative depigmentation using two laser wavelengths; Diode 940 nm…
- Trial name
- NCT04680806
- Testing
- Er,Cr:YSGG laser 2780 nm, Diode laser 940 nm
- Where
- Qatar
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academy of Laser Dentistry - Gulf Laser Chapter
Gut Microbiota, Hyperglycemia
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
Mexico is going through a major environmental and nutritional crisis, which is related to unsustainable dietary behaviors. Sustainable diets could solve both problems together.
- Conditions
- Gut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLC
- Trial name
- NCT05457439
- Testing
- Sustainable diet promotion through behavioral change intervention
- Where
- Mexico
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Wrinkle Appearance, Melanin Hyperpigmentation
Retrospective Follow-up Study on Lower Eyelid Melanin and Wrinkles After Blepharoplasty for Lower Eyelid Bags
This observational study aims to investigate the long-term outcomes of transconjunctival lower eyelid blepharoplasty, with a specific focus on changes in lower eyelid hyperpigmentation or hypopigmentation and morphological…
- Trial name
- NCT07481695
- Testing
- transconjunctival lower blepharoplasty, POD lifting
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Melasma
Oral Tranexamic Acid and Laser for Treatment of Melasma
Tranexamic acid and 1927 diode laser non-ablative fractionated laser for the treatment of Melasma.
- Trial name
- NCT03686787
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laser and Skin Surgery Center of New York
Melasma
Curcuma Xanthorriza Roxb. 10% Cream for Melasma
Melasma is an acquired hyperpigmentation disorder with a multifactorial etiology and complex pathogenesis that can significantly diminish the quality of life for affected patients.
- Trial name
- NCT06153134
- Testing
- 10% Curcuma xanthorriza Roxb., 2% Kojic Acid
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Post-inflammatory Hyperpigmentation
An In Vivo Model for Postinflammatory Hyperpigmentation
Post-inflammatory hyperpigmentation (PIH) is an acquired hypermelanosis that occurs after cutaneous inflammation or injury that frequently affects darker skinned populations.
- Trial name
- NCT02905903
- Testing
- Tricholoacetic Acid (TCA)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
The long-term goal of our PIC is to develop effective strategies that can be applied clinically at the point-of-care to prevent, intercept, or detect PDAC at an early stage, thereby reducing PDAC burden and saving lives.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pancreatic Cyst, Chronic Pancreatitis, Fatty Pancreas
- Trial name
- NCT05692596
- Testing
- Data collection
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Wrinkle, Photoaging
An Exploratory Investigation of a Novel Skincare Regimen
This trial will assess the effectiveness of the Aria Trio Complete Facial system in being able to reduce blemishes, lines, and wrinkles.
- Conditions
- Wrinkle, Photoaging, Acne, Skin Inflammation
- Trial name
- NCT05517720
- Testing
- Aria Trio complete Facial System
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Trophy Skin
Hyperpigmentation, Dark Spots
A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmentation
This was a single-center, double-blinded, randomized, controlled cosmetic clinical trial to investigate the efficacy and tolerance of dark spot corrector serum and regimen skincare products when used over the course of 16 weeks…
- Trial name
- NCT07468175
- Testing
- Cosmetic dark spot corrector serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Obesity, Acanthosis Nigricans
Children's Healthy Living Community Randomized Trial
The goal is to build social/cultural, political/economic, and physical/built environments that will promote active play and intake of healthy food to prevent young child obesity in the Pacific Region.
- Conditions
- Obesity, Acanthosis Nigricans, Central Obesity
- Trial name
- CHL (NCT01881373)
- Testing
- CHL program, Delayed Optimized CHL program
- Where
- United States
- Volunteers
- 9,840 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Effect of Drugs, Adverse Effects of Medical Drugs
Comparison of Efficacy of Tranexamic Acid Mesotherapy Versus 0.9% Normal Saline for Melasma
It is a randomized controlled trial in which investigators determine the efficacy of tranexamic acid (TA) by mesotherapy in comparison to normal saline on participants having Melasma.
- Trial name
- NCT04170088
- Testing
- Tranexamic Acid, 0.9% Normal Saline
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Post Inflammatory Hyperpigmentation
The Efficacy of Bakuchiol in Treating PIH
Post-inflammatory hyperpigmentation (PIH) is an acquired hyper melanosis that occurs after cutaneous inflammation or injury frequently affecting darker skinned individuals.
- Trial name
- NCT06833996
- Testing
- Bakuchiol, Vehicle
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Wrinkles, Fine Lines
Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects.
This is a randomized, double-blind, comparative, two-arm, prospective, interventional, multi-centre clinical study to evaluate the safety, efficacy, and in-use tolerability of test products, standardized saffron extract capsules…
- Conditions
- Wrinkles, Fine Lines, Hyperpigmentation, Dark Spots
- Trial name
- GLOW (NCT07324759)
- Testing
- Standardized Saffron Extract (Crocus Sativus L) 10 mg Capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Solar Lentigines
A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy
To evaluate safety and efficacy of Tri-Luma® cream as an adjunctive treatment to cryotherapy when used in the pre- and post-procedure phases for the treatment of solar lentigines on the back of the hands and in the prevention of…
- Trial name
- NCT01778179
- Testing
- Tri-luma, Cryotherapy (CRY-AC3® device)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Skin Aging of Face and Hands, Facial Wrinkles - Rough Texture - Hyperpigmentation
DMAE Oleate for Facial Skin Firmness and Fine Lines in Healthy Adults
This single-arm, cosmetic study will evaluate the efficacy of topical DMAE Oleate on facial skin firmness and lines/wrinkles in healthy adults.
- Conditions
- Skin Aging of Face and Hands, Facial Wrinkles - Rough Texture - Hyperpigmentation, Skin Laxity
- Trial name
- NCT07255560
- Testing
- Topical DMAE Oleate
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Epidermal Growth Factor, Nd-yttrium Aluminum Garnet Laser
Effectiveness of Epidermal Growth Factor-containing Ointment on the Solar Lentigines
Subjects were randomly assigned to groups for treatment with either an EGF-containing ointment (the study group) or the vehicle alone (petrolatum; the control group). The EGF ointment included recombinant human EGF (1 μg/g).
- Conditions
- Epidermal Growth Factor, Nd-yttrium Aluminum Garnet Laser, Hyperpigmentation, Post Inflammatory Hyperpigmentation
- Trial name
- NCT04704245
- Testing
- epidermal growth factor (EGF)-containing ointment, Vehicle ointment, Q-swithced (QS) 532-nm Nd:yttrium aluminum garnet (YAG) laser
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Acne, Melasma
The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic Dermatitis
The study is conducted to determine if image-based computer grading can of acne, melasma, rosacea and seborrheic dermatitis correlate well to expert based clinical severity grading.
- Conditions
- Acne, Melasma, Rosacea, Seborrheic Dermatitis
- Trial name
- NCT05942248
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Melasma
Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma
The primary objective of our study is to determine the efficacy of combined topical cysteamine cream with a 1927 diode non-ablative laser (Clear + Brilliant Permea®; Solta Medical, Inc.), compared to topical cysteamine (Cyspera)…
- Trial name
- NCT05656833
- Testing
- Fractional 1927nm Low-Powered Diode Laser, Topical Cysteamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- UnionDerm