Clinical trials: Hypersplenism
Liver Cirrhosis, HCC - Hepatocellular Carcinoma
Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function
Splenectomy may relieve hypersplenism, reverse liver fibrosis, improve hepatic functional reserve, and reshape the systemic antitumor immune milieu by removing the source of negative immunomodulation.
- Conditions
- Liver Cirrhosis, HCC - Hepatocellular Carcinoma, Hypersplenism
- Trial name
- LHCS-HFRI (NCT07811687)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Lipid Profiles, Cirrhosis, Liver
Effect of LSD on Lipid Profiles Within 1 Year Postoperatively in Cirrhosis Patients With Portal Hypertension Bleeding
Patients with liver cirrhosis frequently exhibit dyslipidemia due to impaired hepatic lipid synthesis, altered bile acid metabolism, and portal hypertension.
- Conditions
- Lipid Profiles, Cirrhosis, Liver, Portal Hypertension, Splenectomy; Status
- Trial name
- LSD-LPPH (NCT07811700)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Northern Jiangsu People's Hospital
Autoimmune Lymphoproliferative Syndrome
Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of the immune system caused by a mutation in the FAS gene. In ALPS, the body stores too many germ-fighting cells called lymphocytes.
- Trial name
- NCT06730126
- Testing
- Soquelitinib
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Secondary Hypersplenism
A Single-Arm Clinical Trial of Percutaneous Splenic Ablation Combined With Splenic Artery Occlusion for Secondary Hypersplenism.
This study assesses the effectiveness of microwave ablation of the spleen in conjunction with splenic artery occlusion for treating secondary hypersplenism.
- Trial name
- NCT06292715
- Testing
- microwave ablation of the spleen, Splenic artery balloon implantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Cirrhosis, Splenectomy; Status
Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue
- Trial name
- LS-RF (NCT07585773)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhosis, Liver, Splenectomy; Status
Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)
Patients with liver cirrhosis frequently exhibit dyslipidemia due to impaired hepatic lipid synthesis, altered bile acid metabolism, and portal hypertension.
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Portal Hypertension, Lipid Profiles
- Trial name
- LSD-LPPH (NCT07588334)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhosis, Splenectomy; Status
Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)
Patients with liver cirrhosis frequently exhibit dyslipidemia due to impaired hepatic lipid synthesis, altered bile acid metabolism, and portal hypertension.
- Conditions
- Cirrhosis, Splenectomy; Status, Hypersplenism, Lipid Profiles
- Trial name
- LS-LP-CH (NCT07588373)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhosis, Hypersplenism
Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection
This study aimed to evaluate the effectiveness and safety of vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection, and to assess its impact on postoperative digestive complications and quality of life.
- Conditions
- Cirrhosis, Hypersplenism, Hypertension, Portal
- Trial name
- VNLSD (NCT07462091)
- Testing
- Vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection
- Where
- 2 sites in China
- Volunteers
- 15 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhosis, Splenectomy
Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD
The purpose of this study is to determine whether Apixaban is effective and safe in the treatment of portal vein thrombosis Occurring more than one year after laparoscopic splenectomy and azygoportal disconnection.
- Conditions
- Cirrhosis, Splenectomy, Portal Vein Thrombosis, Hypertension, Portal
- Trial name
- NCT07461532
- Testing
- Apixaban 2.5 MG
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia
Hematological Disorders in EHPVO Patients
This study focuses on patients who have a condition called extrahepatic portal vein obstruction (EHPVO), where a blood clot blocks the portal vein outside the liver.
- Conditions
- Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia, Myeloproliferative Neoplasms (MPN), Antiphospholipid Syndrome (APS)
- Trial name
- EHPVO-HEM (NCT07108023)
- Testing
- No intervention (Observational Study)
- Volunteers
- 115 people
- Sponsor
- Rahab Nady
Hepatic Cirrhosis, Portal Hypertension
The Treatment of Hepatocirrhosis and Portal Hypertension
This study compare the efficiency of partial splenic embolization +endoscopical therapy with endoscopical therapy alone in gastroesophageal variceal haemorrhage accompanied with splenomegaly or hypersplenism of hepatocirrhosis…
- Trial name
- NCT02778425
- Testing
- Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, beta blockers
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Yanjing Gao
Hypersplenism
Transfemoral Versus Transradial Partial Splenic Artery Embolization in Patients With Hypersplenism
The present study aimes at comparing the transradial and transfemoral approaches for partial splenic embolization in patients with hypersplenism.
- Trial name
- NCT05446116
- Testing
- partial splenic artery embolization
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Zagazig University
Liver Cirrhosis, Esophageal and Gastric Varices
A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism
The purpose of this study was to compare the effects of partial splenic artery embolization combined with endoscopic treatment and endoscopic treatment alone on portal hypertension in cirrhosis with hyperplenism or splenomegaly…
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hypersplenism
- Trial name
- NCT05055713
- Testing
- Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, Endoscopic therapy
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Qilu Hospital of Shandong University
Cystic Fibrosis Liver Disease, Portal Hypertension Due to Cystic Fibrosis (Disorder)
Pre-emptive Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Cystic Fibrosis Related Liver Disease
Portal hypertension (PHT) and its sequelae are the most clinically important manifestation in cystic fibrosis related liver disease (CFLD), with end-stage liver failure as a late and rare manifestation.
- Conditions
- Cystic Fibrosis Liver Disease, Portal Hypertension Due to Cystic Fibrosis (Disorder), Portal Hypertension, Noncirrhotic
- Trial name
- NCT05037643
- Testing
- TIPS
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Gastroesophageal Varices, Hypersplenism
EUS-guided PSE in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension
This study aims to evaluate the efficiency of EUS-guided combination therapy (EUS-guided PSE + EUS-guided treatment of varices) to EUS-guided treatment of varices alone in cirrhotic patients with portal hypertension who have…
- Conditions
- Gastroesophageal Varices, Hypersplenism, Portal Hypertension
- Trial name
- NCT04692805
- Testing
- coils, cyanoacrylate glue
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Hypersplenism
Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension
The spleen could be considered a neglected organ. To date, it has been deemed an ancillary organ in portal hypertension or an organ localization in lymphoproliferative diseases.
- Trial name
- NCT03269877
- Volunteers
- 400 people
- Sponsor
- Assiut University
Hypersplenism
Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism
The aim of this study is to compare microwave thermal coagulation and partial splenic embolization in the management of hypersplenism in patients with cirrhosis.
- Trial name
- NCT02261584
- Testing
- Microwave Thermal Coagulation, Partial Splenic Embolization
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
ALPS, Hypersplenism
Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)
This study will test whether valproic acid (Depakote[Registered Trademark]) can shrink enlarged lymph glands and spleen in patients with autoimmune lymphoproliferative syndrome (ALPS).
- Conditions
- ALPS, Hypersplenism, Lymphadenopathy
- Trial name
- NCT00605657
- Testing
- Valproic Acid, CT Scan, Blood Sample
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Koneti Rao