Clinical trials: Hypertension, Pregnancy Induced
Preeclampsia, Hypertension
Cardiac and Immune Cell Function in Preeclampsia
Preeclampsia is a multi-system vascular disease which affects 2-5% of pregnancies. It is also a risk factor for the development of cardiovascular disease later in life and a number of functional and structural cardiac changes…
- Conditions
- Preeclampsia, Hypertension, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- NCT04508582
- Testing
- Cardiovascular magnetic resonance, Echocardiography, Blood test
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Renal Cancer
Mechanisms of Anti-VEGF Induced Hypertension
Background: High blood pressure is a common complication observed in cancer patients prescribed anti-VEGF drugs. Increased blood pressure increases the risk of heart attacks and strokes, thus adversely affecting survival and…
- Trial name
- NCT02156310
- Where
- Australia
- Volunteers
- 2,000 people
- Sponsor
- Arduino Mangoni
Pre-Eclampsia; Mild, Gestational Hypertension
Effect of RIC on BP and Inflammatory Response in Women With Pre-eclampsia
The aim of this pilot cohort study is to investigate whether treatment with remote ischemic conditioning (RIC) has a beneficial effect on blood pressure as well as the immune system in pregnant women with newly diagnosed…
- Trial name
- NCT03323762
- Testing
- Remote Ischaemic Conditioning (RIC)
- Where
- 3 sites in Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Pre-Eclampsia
Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level
Magnesium sulphate is an inorganic salt with multiple therapeutic applications in medicine it has been widely utilized and studied on a diverse set of conditions such as asthma, cardiac arrhythmia and stroke.
- Trial name
- NCT03928691
- Testing
- Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Pregnancy Related, Pre-Eclampsia
Natural Versus Programmed Frozen Embryo Transfer (NatPro)
NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed…
- Trial name
- NatPro (NCT04551807)
- Testing
- Modified natural cycle, Programmed cycle
- Where
- 15 sites in United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Pre-Eclampsia
Optic Nerve Sheath Diameter for Volume Status Prediction in Severe Preeclampsia
A quick, non-invasive, bedside test to assess fluid status of patients with severe preeclampsia would be very helpful to ICU clinicians severe preeclampsia is associated with an increase in extravascular lung water (EVLW), which…
- Trial name
- NCT04367519
- Testing
- Ultrasound measurement of Optic nerve sheath diameter
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Severe Preeclampsia, Antiphospholipid Syndrome
Antiphospholipid Antibodies and Early Severe Preeclampsia.
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and…
- Trial name
- NCT01538121
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama
Pregnancy, Gestational Diabetes Mellitus (GDM)
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy
This study is a randomized controlled clinical trial designed to evaluate the effect of a polyphenol-rich dietary intervention during pregnancy on endothelial function, oxidative stress biomarkers, and maternal and neonatal…
- Conditions
- Pregnancy, Gestational Diabetes Mellitus (GDM), Preeclampsia, Hypertension, Pregnancy-Induced
- Trial name
- PREGPOLY (NCT07656532)
- Testing
- Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Preeclampsia
Low Dose Aspirin in the Prevention of Preeclampsia in China
Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results.
- Trial name
- APPEC (NCT02797249)
- Testing
- Aspirin, Blank
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University First Hospital
Pre-eclampsia
Early Placental Insufficiency Screening
To assess the role of uterine artery and maternal serum PlGf and sflt-1 and their combination in screening for pre-eclampsia and small -for-gestational age (SGA) fetuses at 12-14 weeks of gestation
- Trial name
- BIODOP-T1 (NCT01348711)
- Where
- 4 sites in France
- Volunteers
- 226 people
- Sponsor
- University Hospital, Tours
Pregnancy Related, Pre-Eclampsia
CONNEQT Pulse Validation Study
The purpose of this study is to validate the accuracy of the CONNEQT Pulse blood pressure monitoring system for the measurement of blood pressure as compared to a gold standard, auscultatory sphygmomanometer in a pregnant…
- Conditions
- Pregnancy Related, Pre-Eclampsia, Gestational Hypertension
- Trial name
- NCT06002971
- Testing
- Blood pressure measurement
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Mount Carmel Health System
Severe Pre-eclampsia
Ultrasonographic Diameter of Optic Nerve Sheath in Fluid Assessment in Severe Preeclamptic Patients
Changes in the optic nerve sheath diameter detected by ultrasound are considered an important manifestation of increased intracranial pressure .
- Trial name
- NCT05176652
- Testing
- ultrasound
- Where
- 3 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Preeclampsia, Lung Edema
Artificial Intelligence in Lung Ultrasound for Preeclampsia
A total of eight quadrants of standard lung US examination was performed to all pregnant women with preeclampsia within the scope of the study by the same anesthesiologist, dividing each hemithorax into four regions through the…
- Trial name
- NCT05487014
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Gazi University
Hypertension in Pregnancy
L-arginine Effects on Chronic Hypertension in Pregnancy
The purpose of this study is to evaluate the effects of oral L-arginine administration on pregnant women at second trimester of gestation with chronic hypertension, respect with placebo.
- Trial name
- NCT00974714
- Testing
- L-arginine
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Modena and Reggio Emilia
Anemia of Pregnancy, Gestational Diabetes
SMART Health Pregnancy 2 - Intervention to Reduce Anaemia and Cardiometabolic Risk During Pregnancy and in the First Year Following Birth
The goal of this clinical trial is to determine if a complex intervention called SMARThealth Pregnancy can improve the detection and management of high-risk conditions during pregnancy and in the first year after birth in women…
- Conditions
- Anemia of Pregnancy, Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- NCT05752955
- Testing
- SMARThealth Pregnancy
- Where
- India
- Volunteers
- 3,446 people
- Sponsor
- The George Institute
Pre-Eclampsia
Role of Vaspin in Pathophysiology of Pre-eclampsia
To investigate the possible role of vaspin and apoptosis in pre-eclamptic obese women . To compare the serum as well as placental level of vaspin in normotensive and severe pre-eclamptic obese women.
- Trial name
- NCT06437535
- Volunteers
- 75 people
- Sponsor
- Assiut University
Pre-Eclampsia, Gestational Diabetes
Development of Intervention for Women After Gestational Diabetes or Pre-eclampsia
Our objectives in this qualitative exploratory study: To explore the perspectives and preferences of women with preeclampsia and/or GDM history related to a potential health promotion program To identify perception of support…
- Trial name
- NCT04716244
- Testing
- interview/focus group/questionnaire
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Pre-Eclampsia
Interest of Circulating Endothelial Biomarkers in Vascular Pregnancy Complications
This is a prospective multicentric study including four clinical units of Gynecology and Obstetrics (3 public health hospitals and one private team), one research team in Hematology and one Center of Clinical investigation (CIC).
- Trial name
- NCT00485784
- Testing
- Blood test
- Where
- 4 sites in France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pregnancy Related, Fetal Growth Retardation
Pregnancy Repository
An essential part of clinical research is the availability and accessibility of human biospecimens for the identification of biomarkers, new treatments and measurement of response to therapy.
- Conditions
- Pregnancy Related, Fetal Growth Retardation, Placental Insufficiency, Preeclampsia
- Trial name
- PR (NCT06339606)
- Testing
- Biospecimen collection
- Volunteers
- 7,000 people
- Sponsor
- Sunnybrook Health Sciences Centre
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