Clinical trials: Hypertension, Resistant to Conventional Therapy
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Hypertension Resistant to Conventional Therapy, Kidney Failure, Chronic
Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension
In this study the investigators are going to assess the feasibility of this innovate technique of renal sympathetic denervation by translumbar access under ct-guidance.
- Trial name
- SCRATCH (NCT02653222)
- Testing
- Renal sympathicolysis, Ambulatory Blood Pressure Monitoring, Magnetic Resonance Angiography
- Where
- 2 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Grenoble
Hypertension, Resistant to Conventional Therapy
Addition of Homeopathy in Patients With Resistant Arterial Hypertension
Resistant hypertension (RHTN) is a common clinical problem faced by both primary care clinicians and specialists worldwide. Patients with RHTN have higher rates of cardiovascular events and mortality compared with patients with…
- Trial name
- NCT02124473
- Testing
- Homeopathy
- Where
- 2 sites in India
- Volunteers
- 79 people
- Sponsor
- Macmillan Research Group UK
Hypertension, Resistant to Conventional Therapy
Renal Denervation in Refractory Hypertension
Open, multicenter, randomized study is enrolling patients in 3 sites in Czech Republic. Patients with refractory hypertension will be randomized in 1:1 manner either to renal denervation plus optimal medical antihypertensive…
- Trial name
- PRAGUE-15 (NCT01560312)
- Testing
- Renal denervation (Symplicity® Catheter System™)
- Where
- 3 sites in Czechia
- Volunteers
- 106 people
- Sponsor
- Charles University, Czech Republic
Hypertension, Hypertension Resistant to Conventional Therapy
High Prevalence of Secondary Arterial Hypertension (HIPRESH) with Prospective Systematic Screening in a Cohort of Consecutive Hypertensive Patients Referring to Regional Specialized Center
Hypertensive Patients referring to our center will undergo a systematic diagnostic workup aimed at finding the cause(s) of their high blood pressure.
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Secondary Hypertension to Endocrine Disorders, Secondary Hypertension
- Trial name
- HIPRESH (NCT06664255)
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Padova
Hypertension, Hypertension, Resistant to Conventional Therapy
RADIANCE Continued Access Protocol
RADIANCE CAP is a non-randomized study designed to allow for continued access to ultrasound renal denervation therapy via the Paradise System, and to allow for the on-going collection of safety and effectiveness data in subjects…
- Conditions
- Hypertension, Hypertension, Resistant to Conventional Therapy, Vascular Diseases, Cardiovascular Diseases
- Trial name
- RADIANCE CAP (NCT05017935)
- Testing
- Renal Denervation
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- ReCor Medical, Inc.
Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension
This is a four-week randomized controlled single blinded trial of subjects presenting with resistant hypertension in a specialized diabetes care unit of Cameroon.
- Trial name
- SPIRY (NCT02426099)
- Testing
- Low dose spironolactone, Routine intensification of antihypertensive treatment
- Where
- Cameroon
- Volunteers
- 17 people
- Sponsor
- Sobngwi Eugene
Hypertension, Resistant to Conventional Therapy, Renal Denervation
Renal Denervation in Hypertension
The DENER-HTN study is a, multicenter, prospective, open, randomized, controlled study of the effectiveness and costs of renal denervation in addition to standardized medical treatment compared to medical treatment alone in…
- Trial name
- DENER-HTN (NCT01570777)
- Testing
- renal denervation and optimized medication regimen, optimized medication regimen
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Resistant to Conventional Therapy
Distal Renal Denervation
Objective of this study is to evaluate whether a distal mode of endovascular renal denervation with the treatment performed primarily in segmental branches of renal artery is more effective than conventional mode of the…
- Trial name
- NCT02667912
- Testing
- Distal renal denervation, Conventional renal denervation
- Where
- Russia
- Volunteers
- 55 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy
Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE
EMBRACE is a randomized, controlled, multicenter clinical study evaluating the effect of renal denervation on clinical adverse events in hypertensive patients undergoing staged percutaneous coronary intervention (PCI) for…
- Trial name
- EMBRACE (NCT07602790)
- Testing
- Renal denervation
- Volunteers
- 1,000 people
- Sponsor
- Ceric Sàrl
Hypertension, Resistant to Conventional Therapy
How to Test Success of a Renal Denervation
The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.
- Trial name
- NCT02559882
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Arterial Hypertension, Hypertension, Resistant to Conventional Therapy
The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension
The purpose of this study is to estimate the effect of spironolactone on blood pressure resistant to therapy in type-2 diabetics.
- Conditions
- Arterial Hypertension, Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
- Trial name
- SDHDS (NCT01062763)
- Testing
- spironolactone
- Volunteers
- 119 people
- Sponsor
- Ib Abildgaard Jacobsen
Hypertension, Resistant to Conventional Therapy
Optimum Treatment for Drug-Resistant Hypertension
This study was recommended by NICE, as part of its 2006 guidance for the treatment of hypertension, and is urgently required to provide evidence for the treatment recommendations in patients with resistant hypertension.
- Trial name
- PATHWAY2 (NCT02369081)
- Testing
- Spironolactone, Bisoprolol, Doxazosin
- Where
- 16 sites in United Kingdom
- Volunteers
- 348 people
- Sponsor
- University of Cambridge
Hypertension, Resistant to Conventional Therapy
Health Coaching Based Treatment Versus Usual Treatment of Systemic Arterial Hypertension and Comorbidities
Hypertension is a multifactorial clinical condition, it may not cause symptoms and its diagnosis is often delayed. And even when it is diagnosed early, some patients cannot manage an adequate blood pressure.
- Trial name
- NCT03046680
- Testing
- Health Coaching, Multiprofessional Team
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Universidade Federal de Goias
Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy
UK Registry for Baroreflex Activation Therapy
This study is a post-marketing open label single arm, single centre clinical trial of electrical carotid sinus stimulation with the Barostim Neo device to target sub-optimally controlled arterial hypertension or highly variable…
- Trial name
- UK-BAT (NCT03730519)
- Testing
- Baroreflex Activation Therapy with Barostim Neo
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Queen Mary University of London
Medication Nonadherence, Hypertension, Resistant to Conventional Therapy
The Use of Educational Technology in Improving Adherence Therapy
Few studies show the benefits of educational technologies a support for the control of chronic diseases. The approach known as 'embracement' adopts relational strategies or soft technologies which promote bonding and may impact…
- Trial name
- NCT03324386
- Testing
- Experimental: Individual Orientation, Experimental: VLE for Distance Learning, Experimental: E-blended Lerarning
- Volunteers
- 57 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertensive Disease, Hypertension, Resistant to Conventional Therapy
Medication Adherence and "True" Resistance in Patients With Resistant Hypertension
The purpose of this study is to estimate the proportion of patients with "true" resistance among patients referred to the Medical Outpatient Department of the Charité - Universitätsmedizin Berlin with the diagnosis "resistant…
- Trial name
- NCT02128386
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension Resistant to Conventional Therapy
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension
A randomized clinical trial comparing sequential nephron blockage (SNB) with dual blockade of the renin-angiotensin system (RAAS) plus bisoprolol (DBB) in the treatment of resistant arterial hypertension (RH) was designed to…
- Trial name
- ResHypOT (NCT02832973)
- Testing
- Spironolactone, Furosemide,, Amiloride
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Hypertension, Hypertension Resistant to Conventional Therapy
Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)
The ANDORRA study is a, multicenter, prospective, open, randomized, controlled blinded endpoint trial (PROBE) comparing two treatment strategies (renal artery stenting + standardized and optimized medical treatment [SOMT] versus…
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
- Trial name
- ANDORRA (NCT02539810)
- Testing
- Renal artery Angioplasty plus stenting., Anti hypertensive, statin and antiplatelet medication.
- Where
- 15 sites in France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension Resistant to Conventional Therapy, Bradycardia
Moderato System: A Double-Blind Randomized Trial Ver 1.1
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Conditions
- Hypertension Resistant to Conventional Therapy, Bradycardia, Atrioventricular Block
- Trial name
- NCT02837445
- Testing
- PHC ON, PHC OFF
- Where
- 12 sites in Austria, Belgium and 5 more
- Volunteers
- 70 people
- Sponsor
- BackBeat Medical Inc