Clinical trials: Hypertensive Disorder of Pregnancy
Endotoxemia
Effect of Selective iNOS Inhibition During Human Endotoxemia
Sepsis or endotoxemia is manifested by hypotension, resistance to vasopressors, myocardial depression,and altered organ blood flow distribution.
- Trial name
- NCT00184990
- Testing
- Aminoguanidine, endotoxin
- Where
- Netherlands
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Preeclampsia
Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort
This study intends to adopt the method of multi-center prospective randomized controlled study. The aim of this study is to obtain localized excision values through a preeclampsia screening model established in early pregnancy…
- Trial name
- NCT04631627
- Testing
- Aspirin
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Preeclampsia
Predictors of Aspirin Failure in Preeclampsia Prevention
Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies.
- Trial name
- NCT05709483
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Endotoxemia
Ethnic Differences in the Inflammatory Response in Systemic Inflammation
The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.
- Trial name
- NCT00284869
- Testing
- LPS
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pre Eclampsia
Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Adult Volunteers
The research team has developed an automatic blood pressure monitor (Sphygmo) to be used for the monitoring and diagnosis of pre-eclampsia in pregnant women, particularly in low-resource settings where current monitoring is…
- Trial name
- NCT02267577
- Testing
- Sphygmo: Automatic Blood Pressure Monitor, GE Dinamap ProCare Automatic Blood Pressure Monitor
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- William Marsh Rice University
Hypertensive Disorder of Pregnancy
Feasibility and Acceptability of Risk Stratification in the Fourth Trimester to Reduce Maternal Morbidity and Mortality
Hypertensive disorders of pregnancy (HDP) are major causes of maternal morbidity and mortality globally and are associated with peripartum and future cardiovascular disease, including stroke, heart failure, and myocardial…
- Trial name
- NCT05631067
- Testing
- Remote blood pressure monitoring, NT proBNP assessment
- Where
- Nigeria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Kidney Disease, Hypertrophy, Left Ventricular
Effects of a Reduction in Renal Function on Cardiovascular Structure and Function
Chronic kidney disease (CKD) is present in 1 in 7 of the population and confers a high risk of cardiovascular disease. The pathophysiology of cardiovascular disease in CKD is poorly understood because CKD is always accompanied by…
- Conditions
- Chronic Kidney Disease, Hypertrophy, Left Ventricular, Hypertension
- Trial name
- CRIB-DONOR II (NCT02973607)
- Testing
- Nephrectomy
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Endotoxemia, Systemic Inflammatory Response
PK/PD of EA-230 During Endotoxemia
EA-230 is a newly developed synthetic compound with anti-inflammatory properties. Pre-clinical data indicate that EA-230 may be a valuable treatment for systemic inflammation resulting from a variety of causes such as surgery…
- Trial name
- NCT02629874
- Testing
- EA-230, Endotoxin
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
The purpose of this study is to determine the effects of HMG-CoA reductase inhibitor pretreatment on inflammation and coagulation activation in human endotoxemia.
- Trial name
- NCT00309374
- Testing
- LPS 2ng/kg intravenous bolus, Simvastatin 80mg; administered daily p.o. over 5 days, Rosuvastatin 40mg; administered daily p.o. over 5 days
- Where
- Austria
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Endotoxemia
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- NCT01091571
- Testing
- Dipyridamole, LPS
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Abruptio Placentae; Affecting Fetus or Newborn
Normotensive and Hypertensive Placental Abruptions
Placental abruption is a significant cause of both maternal morbidity and neonatal morbidity and mortality. Most abruptions accept to be related to a chronic placental disease process.
- Trial name
- NCT04449601
- Testing
- clinical assesment
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hatice Akkaya
Pregnancy Complications, Pregnancy, High Risk
Active Pregnancy Against COVID-19
Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence.
- Conditions
- Pregnancy Complications, Pregnancy, High Risk, Pregnancy Induced Hypertension, Newborn Morbidity
- Trial name
- ACPREGCOV (NCT04563065)
- Testing
- Exercise program, Healthy lifestyle advise
- Where
- 2 sites in Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Hypertension, Pregnancy-Induced
Evaluation of an Information Pamphlet for Postpartum Women That Had a Hypertensive Pregnancy
It is known that preeclampsia is a risk factor for cardiovascular diseases, diabetes, chronic hypertension, nephropathy and thromboembolism.
- Trial name
- NCT02523781
- Testing
- information pamphlet
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia (PE)
Non-Invasive Preeclampsia Screening and Biobank
Women pregnant between 11-14 weeks gestation will be enrolled with blood samples collected to evaluate for preeclampsia.
- Trial name
- NCT06643741
- Where
- 21 sites in United States
- Volunteers
- 6,550 people, healthy volunteers welcome
- Sponsor
- Sequenom, Inc.
Pre-Eclampsia
Impact of Antichlamydial Treatment on the Rate of Preeclampsia
This randomized, double blinded controlled trial included 1200 healthy primigravidae who attended an outpatient clinic at 16-20weeks of pregnancy.
- Trial name
- NCT03233880
- Testing
- Azithromycin 1gm
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Heart Failure, Hypertension
Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers
The human heart produces hormones that help regulate blood pressure and fluid balance in the body. One of these hormones is atrial natriuretic peptide (ANP).
- Conditions
- Heart Failure, Hypertension, Kidney Failure
- Trial name
- NCT07606183
- Testing
- Infusion of two different cardiac peptides plus vehicle
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Peter Fruergaard Andersen