Clinical trials: Hypertrophy, open to volunteers
Spinal Stenosis of Lumbar Region, Spine Degeneration
Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis
Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration.
- Trial name
- APIDeLeG (NCT07026552)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Benign Prostate Hypertrophy(BPH)
Orientation Video Training Administered at Different Times to Patients Undergoing Prostate Surgery on Postoperative Pain and Anxiety (Video Training)
This study aims to evaluate the effect of operating room orientation video education delivered at different time points on postoperative pain and state anxiety in patients undergoing surgery for benign prostatic hyperplasia.
- Trial name
- NCT07778355
- Testing
- Operating Room Orientation Video Education, Routine Preoperative Information
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Ondokuz Mayıs University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Type II Endoleak, Abdominal Aortic Aneurysm Enlargement
Deep-learning Predictors of Abdominal Aortic Aneurysm Enlargement in Type II Endoleaks After Endovascular Aortic Repair: The RADAR Study
Background and rationale: Abdominal aortic aneurysm (AAA) is a weakening and enlargement of the main artery in the abdomen. Endovascular aneurysm repair (EVAR) is a minimally invasive treatment used to repair an AAA.
- Trial name
- RADAR (NCT07783126)
- Testing
- Artificial intelligence model analyzing preoperative CT angiography
- Volunteers
- 1,250 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Cancer, Breast Cancer
EXERT-BC Protein: Protein Supplementation to Improve Body Composition After Treatment for Breast Cancer
In this study, the investigators hypothesize that a high dose of post-workout protein after each exercise session will have greater improvements in changes in body composition, including muscle mass and percent body fat versus a…
- Trial name
- NCT07704476
- Testing
- Whey protein (60 grams), No protein
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Maxillary Labial Frenulum Abnormality, Hypertrophic Maxillary Labial Frenulum
970-nm Diode Laser Versus Liquid Nitrogen Cryotherapy in Maxillary Labial Frenectomy
This prospective, randomized, single-blind, assessor-blinded, parallel-group clinical trial aims to compare the effects of 970-nm diode laser and liquid nitrogen cryotherapy in patients requiring maxillary labial frenectomy.
- Trial name
- MLF-DL-KRYO (NCT07708389)
- Testing
- 970-nm Diode Laser Frenectomy, Liquid Nitrogen Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kutahya Health Sciences University
Adenotonsillar Hypertrophy
Teleconsultation vs Face-to-Face Evaluation for Perioperative Respiratory Events in Pediatric Adenotonsillectomy
The goal of this clinical trial is to assess whether preoperative anesthesia teleconsultation is at least equivalent to in-person consultation in preventing perioperative respiratory adverse events (such temporary reduction in…
- Trial name
- Teleped (NCT07175779)
- Testing
- Face-to-Face Preanesthesia Consultation, Telemedicine Preanestehsia Consultation
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Andrea Saporito
Arterial Hypertension
Echocardiographic Analysis by Artificial Intelligence in Hypertension
The objective of this study is to develop artificial intelligence (AI) tools to characterize cardiac remodelling in arterial hypertension through the analysis of routine imaging data (echocardiography) coupled with patient data.
- Trial name
- CARDINAL (NCT06680986)
- Testing
- Clinical cardiac parameters (Arterial pressure, number of anti-hypertensive medications, and the NT-proBNP measurements)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
HoLEP, Trifecta Achievement
Predictors of Trifecta Achievement After HoLEP
Holmium laser enucleation of the prostate (HoLEP) is a surgical treatment option for men experiencing bothersome lower urinary tract symptoms due to an enlarged prostate.
- Conditions
- HoLEP, Trifecta Achievement, Urinary Incontinence Following Surgical Procedure, Clavien Dindo Surgical Complication Scale
- Trial name
- ReMIUS-BPO (NCT07429994)
- Testing
- Transurethral Holmium Laser Enuclation of the Prostate
- Where
- Turkey (Türkiye)
- Volunteers
- 604 people
- Sponsor
- Ondokuz Mayıs University
Gastrointestinal Cancer
A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer
This is a prospective, interventional, open-label, single-arm, multicenter pilot study evaluating the safety, tolerability and maximum tolerated dose (MTD) of splenic Selective Internal Radiation Therapy (SIRT) using TheraSphere…
- Trial name
- SPLENIC-SIRT (NCT07575854)
- Testing
- TheraSphere
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre Georges Francois Leclerc
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic Cardiomyopathy
The study will describe how mavacamten is used in routine care for Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), including use as monotherapy or with other background/concomitant oHCM medications.
- Trial name
- REMAP-HCM (NCT07846059)
- Testing
- Mavacamten
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Bristol-Myers Squibb
Splenomegaly, Myelofibrosis
High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly
To learn if giving ruxolitinib and busulfan before a stem cell transplant can help to reduce spleen size and help the transplant to succeed.
- Trial name
- NCT06345495
- Testing
- Ruxolitinib, Allogeneic Stem Cell Transplantation, Levetiracetam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Spondylotic Myelopathy
Efficacy of Two Approaches in Cervical Single-door Laminoplasty for Spinal Canal Enlargement
The goal of this clinical trial is to learn if cervical single-door laminoplasty via the intermuscular space approach can better prevent axial symptom while reaching equal neurological outcome than the conventional approach in…
- Trial name
- NCT06941649
- Testing
- Expansive open-door laminoplasty via intermuscular space approach, cervical single-door laminoplasty via the conventional approach
- Volunteers
- 376 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hypertrophic Obstructive Cardiomyopathy
Transapical Beating-heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy
The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy.
- Trial name
- NCT05332691
- Testing
- Transapical beating-heart septal myectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiang Wei
HFpEF, LVDD
Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF
Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combination therapy with [angiotensin receptor/neprilysin inhibitor [ARNI]…
- Conditions
- HFpEF, LVDD, Myocardial Fibrosis
- Trial name
- NCT06655480
- Testing
- [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Heart Attack, Enlarged Heart
Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI
The purpose of the research is to determine whether a class of medication called SGLT2 inhibitor will improve the heart's function and reduce its enlargement after a heart attack.
- Trial name
- NCT05305911
- Testing
- SGLT-2 inhibitors
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Minneapolis Heart Institute Foundation
Left Ventricular Hypertrophy
Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects…
- Trial name
- SPEC (NCT04644094)
- Testing
- Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Friedreich Ataxia, Cardiomyopathies
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
The purpose of this study is to test the safety and preliminary efficacy of AAVrh.10hFXN to treat the cardiomyopathy associated with Friedreich's ataxia (FA).
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Cardiac Hypertrophy, Myocardial Fibrosis
- Trial name
- NCT05302271
- Testing
- AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN, Prednisone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Skin Wound, Scar, Hypertrophic
Umbilical Cord Stem Cells for Skin Grafts in Donor Site Wounds
The goal of this clinical trial is to evaluate the safety and effectiveness of human umbilical cord mesenchymal stem cell (hUCMSC) therapy in patients undergoing medium-thickness skin grafts for donor site wounds.
- Trial name
- NCT05984628
- Testing
- human umbilical cord mesenchymal stem cells, blank solvent
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Acne, Acne Scars - Mixed Atrophic and Hypertrophic
AVAVA MIRIA General Use
A general protocol to treat a variety of dermatologic conditions and collect patient feedback. Primary outcome is the collection and analysis of patient questionnaires related to the overall experience of the device treatment.
- Conditions
- Acne, Acne Scars - Mixed Atrophic and Hypertrophic, Scars, Wrinkle
- Trial name
- NCT06868615
- Testing
- AVAVA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AVAVA, Inc.