Clinical trials: Hypervolemia
Fluid Overload, Vascular Stiffness
Target Weight Correction and Vascular Stiffness in Hemodialysis Patients
Title of the study: Target weight correction and vascular stiffness in hemodialysis patients Study design: Randomized clinical trial in the study centre at two locations Applied medical device: 1.
- Trial name
- NCT03929471
- Testing
- Target weight correction protocol
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Alberta
Hemodilution, Coronary Artery Disease
Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery
Hemodilution reduces concentrations of blood constituents: concentration of hemoglobin, red blood cells (hematocrit), physiological ions and coagulation factors that can contribute to impaired hemostasis and increasing the risk…
- Conditions
- Hemodilution, Coronary Artery Disease, Fluid Overload
- Trial name
- RAPPER-MAN (NCT04870073)
- Testing
- Retrograde autologous priming, Mannitol, Conventional Priming
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Peritoneal Dialysis, Hypervolemia
Lung Ultrasound in PD Patients
Although many alternative methods are present, maintaining ideal volume status in peritoneal dialysis (PD) patients still rely on clinical evaluation due to lack of an evidence based method.
- Conditions
- Peritoneal Dialysis, Hypervolemia, VEGF Overexpression
- Trial name
- LUSiPD (NCT03801044)
- Testing
- NT-BNP, VEGF, Echocardiography, Chest Radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Heart Failure
Efficacy and Safety of Tolvaptan in Japanese Patients With Acute Heart Failure
The aims of the present study are to investigate prospectively the clinical course and outcome of the hospitalized heart failure patients treated with tolvaptan for management of fluid retention and serum sodium levels of less…
- Trial name
- MT FUJI (NCT01635517)
- Where
- Japan
- Volunteers
- 274 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Congestive Heart Failure
Outpatient Ultrafiltration Therapy in Heart Failure Patients Trial
This trial will look at the effectiveness and patient acceptance of ultrafiltration therapy in an outpatient setting. The purpose of this study is to determine if ambulatory patients who suffer from heart failure and hypervolemia…
- Trial name
- NCT00319384
- Testing
- Ultrafiltration therapy
- Where
- United States
- Sponsor
- Hennepin Healthcare Research Institute
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome, Hemodynamic Instability
Thoracic Fluid Content by Bioimpedance-based Starling System
The Starling system is a completely non-invasive hemodynamic monitoring technique. It is able to measure the thoracic fluid content (TFC). The TFC is supposed to reflect the total content of fluid in the thorax.
- Conditions
- Acute Respiratory Distress Syndrome, Hemodynamic Instability, Shock, Fluid Overload Pulmonary Edema
- Trial name
- TFC-Bio (NCT05676723)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Bicetre Hospital
Chronic Kidney Disease Requiring Chronic Dialysis, Hemodialysis, Home
Body Composition Monitor Among Daily Home Dialysis With Low Flow Dialysate
The fluid overload measured by the Body Composition Monitor (BCM Fresenius Medical Care) is a new independent risk factor of mortality.
- Conditions
- Chronic Kidney Disease Requiring Chronic Dialysis, Hemodialysis, Home, Electric Impedance
- Trial name
- VOLODIA (NCT03994133)
- Testing
- Measurement of the hydration state by bio-impedance spectroscopy
- Where
- France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Caen
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
Lung Disease
Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates
The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who are considered at high risk of volume…
- Trial name
- NCT00618852
- Testing
- Furosemide, Saline
- Where
- 2 sites in Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Hypovolemia, Fluid Overload
Prediction of the Effect of Fluid Administration Using Arterial Pressure and Ventilator Data During Abdominal Surgery
It is well known, that patients with circulatory impairment sometimes, but not always, benefit from intravenous fluids. Predicting if a fluid administration will improve circulation is therefore of substantial clinical interest.
- Trial name
- NCT04298931
- Testing
- Series of ventilator settings
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University of Aarhus
Pediatric ALL, Fluid Overload
The Ratio of Femoral Vein Diameter to Femoral Artery Diameter to Predict Fluid Responsiveness in Children
The hypothesis of the study will be that the ratio of femoral vein diameter to femoral artery diameter will have correlation with fluid status in pediatrics.
- Trial name
- NCT05992246
- Testing
- Ratio of Femoral Vein Diameter to Femoral Artery Diameter
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Tanta University
Nocturia, Venous Insufficiency of Leg
Discovering the Effect of Venous Insufficiency on Nocturia
With this prospective controlled trial, we hope to obtain more information about the coexistence between venous insufficiency and nocturia.
- Conditions
- Nocturia, Venous Insufficiency of Leg, Fluid Overload
- Trial name
- DEVINe (NCT04266496)
- Testing
- Questionnaires, Frequency Volume Chart, Collect urine during 1 day
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- University Hospital, Ghent
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypovolemia, Hypervolemia
Perioperative Fluid Therapy Optimization in Spinal Surgery
The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation.
- Trial name
- NCT03644654
- Testing
- Standard care group, Noninvasive monitoring group
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Congestive Heart Failure
Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure
The purpose of this study is to evaluate the effects of oral lixivaptan capsules in patients with congestive heart failure.
- Trial name
- NCT01055912
- Testing
- Lixivaptan
- Where
- 25 sites in United States
- Volunteers
- 170 people
- Sponsor
- CardioKine Inc.
End Stage Chronic Renal Failure, Congestive Heart Failure (CHF)
The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are…
- Conditions
- End Stage Chronic Renal Failure, Congestive Heart Failure (CHF), Intravascular Congestion, Fluid Overload
- Trial name
- FILTRATE (NCT07705269)
- Testing
- High-rate ultrafiltration, Standard fluid removal
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Fluid Overload, Fluid Loss
Evaluating the Fluid Balance of Mechanically Ventilated Patients by Ultrasonography
ratio of the diameter of inferior vena cava to the diameter of the thoracic aorta (IVC / Ao) depends on the daily balance of fluids.
- Trial name
- NCT03204292
- Where
- Poland
- Volunteers
- 57 people
- Sponsor
- Jagiellonian University