Clinical trials: Hypoglycemia
Gestational Diabetes, Hypoglycemia, Neonatal
Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial
Pregnant women with gestational diabetes who are treated with insulin and their daily insulin dose is 30 IU or more will be randomized into two groups. Active treatment group will receive insulin-glucose-infusion during labour.
- Trial name
- NCT02590016
- Testing
- Insulin, Aspart
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Hypoglycemia, Pediatric ALL
Prehospital Provider Training With Augmented Reality (AR)
The goal is to evaluate the acceptance of Augmented Reality (AR) simulation as a learning modality for prehospital providers. The simulation itself is grounded in traditional best practices for simulation delivery and design as…
- Trial name
- NCT05686590
- Testing
- Augmented Reality Headset
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Thomas Caruso
Diabetes Mellitus, Insulin Hypoglycemia
Information and Communication Technology Based Centralized Clinical Trial Monitoring System for Insulin Dose Adjustment
This is a 24-week, open-label, randomized, multi-center trial conducted in three tertiary hospitals. There are three follow-up measures; at baseline, post-intervention at Week 12, and Week 24.
- Conditions
- Diabetes Mellitus, Insulin Hypoglycemia, Insulin-dependent Diabetes Mellitus
- Trial name
- ICT (NCT03112343)
- Testing
- Algorithm-based feedback messages, Personal Health Record
- Where
- South Korea
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Neonatal Hypoglycemia, Gestational Diabetes Mellitus (GDM)
COntinuous Glucose Monitoring in nEwborns of Mothers With Insulin-Treated Gestational Diabetes Mellitus
The purpose of this study is to determine whether continuous glucose monitoring (CGM) improves the detection and management of neonatal hypoglycaemia in newborns of mothers with insulin-treated gestational diabetes.
- Trial name
- COMET-GDM (NCT07462793)
- Testing
- Dexcom ONE Continuous Glucose Monitoring System
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
Effects of Reactive Hypoglycaemia on Cognition in Earlier or Later Chronotypes
Studies suggest a link between lower postprandial glycaemic response and better cognitive performance in children, adolescents, and young adults, though evidence remains inconclusive.
- Trial name
- GlyCoBrainI2 (NCT06941740)
- Testing
- immediate verbal memory after low glycemic index breakfast inducing no reactive hypoglycaemia, immediate verbal memory after low glycemic index breakfast causing reactive hypoglycaemia
- Where
- Germany
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Anette Buyken
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Hyperinsulinemic Hypoglycemia, Postprandial Hypoglycemia
Treatment of Post-bariatric Hypoglycaemia
This is an investigator-initiated, proof-of-concept, randomised, double-blind, placebo-controlled, single-centre phase II study aiming to evaluate the efficacy, safety and tolerability of self-administered subcutaneous 120 µg…
- Trial name
- SHERRY (NCT04836273)
- Testing
- Dasiglucagon, HyoPen
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Filip Krag Knop
Neonatal Hypoglycemia
Effectiveness of Donor Human Milk Supplementation for the Treatment of Hypoglycemia in the Breastfed Infant
The purpose of this study is to compare if newborn infant hypoglycemia can be improved with bottle supplementation of commercially-sterilized donor human milk compared to standard infant formula.
- Trial name
- NCT04030312
- Testing
- Bottle Supplementation--Commercially-Sterilized Donor Human Milk, Bottle Supplementation--Standard Infant Formula
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hypoglycemia
Study of How Low Blood Sugar Affects the Way Blood Vessels Work
Hypothesis: Low blood sugar (hypoglycemia) decreases function of the lining of the blood vessels in normal humans. This study is designed to explore how hypoglycemia affects the function of the blood vessel lining.
- Trial name
- NCT00373854
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Post Bariatric Surgery, Gastric Bypass
The Effects of Bariatric Surgeries on Glucose Metabolism
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
- Conditions
- Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
- Trial name
- NCT02823665
- Testing
- Exendin-(9-39), Atropine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Hypoglycemia, Healthy
Hypoglycemia and Autonomic Nervous System Function-B
This study tests the hypothesis that, compared to prior normal blood sugar, prior low blood sugar impairs cardiovascular autonomic function.
- Trial name
- HypoANS-B (NCT03429946)
- Testing
- Spironolactone, Hypoglycemic Hyperinsulinemic Clamp, Euglycemic Hyperinsulinemic Clamp
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Type 1 Diabetes Mellitus
Automated Insulin Delivery in Elderly With Type 1 Diabetes (AIDE T1D)
A multi-center, randomized, crossover trial consisting of three sequential 12-week periods, with the HCL feature used during one period, the PLGS feature used during one period and SAP therapy (control) during one period.
- Trial name
- AIDE T1D (NCT04016662)
- Testing
- Tandem t:slim X2 with HCL or PLGS
- Where
- 4 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Gastrectomy, Oesophagectomy
Metabolic Consequences of Gastrointestinal Surgery
Surgery on the gastrointestinal (GI) tract results in profound changes to the metabolic profile. This is well described, including the rapid resolution of diabetes seen after bariatric surgery.
- Conditions
- Gastrectomy, Oesophagectomy, Dumping Syndrome, Hypoglycaemia
- Trial name
- MaS (NCT02836353)
- Testing
- Somatostatin, Rifaximin
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Once a Preterm Developed Hypoglycemia, no More Blood Glucose Was Measured During the Study Period.
Dextrose Infusion by Burettes Versus Dextrose Boluses in Prevention of Neonatal Hypoglycemia
NULL HYPOTHESIS • There is no difference in the incidence of hypoglycemia among preterms receiving either two hourly 10% dextrose boluses or 10% dextrose infusion by burettes during the 72 hours of admission in Special Care Unit…
- Trial name
- NCT01688674
- Testing
- 10% dextrose
- Where
- Uganda
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Makerere University
Type 1 Diabetes Mellitus
Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Pancreatic islet transplantation improves glucose counterregulation and stabilizes glycemic control in patients with type 1 diabetes mellitus prone to severe hypoglycemia even if insulin independence is not achieved.
- Trial name
- NCT01668485
- Testing
- Hypoglycemic and euglycemic glucose clamp
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Preoperative Fasting, Perioperative Anxiety
Preoperative Fasting and Perioperative Outcomes in Children Undergoing Elective Circumcision
This prospective observational study aims to evaluate adherence to preoperative fasting guidelines and investigate the relationship between actual fasting durations, anxiety levels, and blood glucose levels in children aged 1-10…
- Conditions
- Preoperative Fasting, Perioperative Anxiety, Perioperative Hypoglycemia
- Trial name
- NCT07876583
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Burcu Ayvazoğlu
Glucose, High Blood, Exercise-Induced Hyperinsulinism
Exercise Type That Faster Reduces Postprandial Glycemia.
It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout.
- Trial name
- GLYEXER (NCT04846751)
- Testing
- TYPE OF EXERCISE (OR REST)
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Diabetes Mellitus, Type 1, Pregnancy
BGAT (Blood Glucose Awareness Training) for Users Who Might Become Pregnant
Ineffective management of blood glucose (BG) levels during preconception and pregnancy has been associated with severe maternal and fetal complications in women with type 1 diabetes (T1DM).
- Trial name
- Bump2Be (NCT02508779)
- Testing
- Bump2be, Routine Care
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus Type I, Hypoglycemia
Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose
Diabetes mellitus type I (DMI) is characterized by lack of endogenous insulin and these patients are 100% dependent on insulin substitution to survive.
- Trial name
- NCT01919788
- Testing
- Insulin (Insuman Rapid), Glucose, Saline
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Aarhus