Clinical trials: Hypokalemia
Hypokalemia, Intensive Care Unit (ICU)
Management of Hypokalemia in Intensive Care Patients
Hypokalemia is a common electrolyte disorder in critically ill patients and may contribute to substantial morbidity and mortality if inadequately managed.
- Conditions
- Hypokalemia, Intensive Care Unit (ICU), Intensive Care Unit (ICU) Patients
- Trial name
- NCT07833722
- Testing
- Implementation of hypokalemia treatment algorithm
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Anadolu University
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Renal Insufficiency, Chronic, Potassium Depletion
Potassium Supplementation in CKD
The current high-sodium, low-potassium diet contributes to the high prevalence of high blood pressure (hypertension). Indeed, the anti-hypertensive effects of potassium supplementation are well-established.
- Conditions
- Renal Insufficiency, Chronic, Potassium Depletion, Hypertension, Hyperkalemia
- Trial name
- K+ in CKD (NCT03253172)
- Testing
- Potassium Chloride, Potassium Citrate
- Where
- 4 sites in Netherlands
- Volunteers
- 532 people
- Sponsor
- Erasmus Medical Center
Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment
Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension
Primary aldosteronism (PA) is characterized by hypertension, frequent hypokalaemia, and an inappropriately high aldosterone-to-renin ratio (ARR).
- Conditions
- Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment, Adrenalectomy
- Trial name
- ADERADHTA2 (NCT07470580)
- Testing
- RFA -radiofrequency ablation, Adrenalectomy
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse
Cushing Disease Due to Increased ACTH Secretion
Combination Osilodrostat and Cabergoline in Cushing's Disease
Cushing disease remains a challenging endocrine disorder in which persistent or recurrent hypercortisolism often requires medical therapy after surgery or when surgery is not feasible.
- Trial name
- COSCA-ECD (NCT07603466)
- Testing
- osilodrostat, osilodrostat and cabergoline
- Where
- 5 sites in Iraq
- Volunteers
- 50 people
- Sponsor
- University of Basrah
Hypertension, Primary Aldosteronism
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy.
- Conditions
- Hypertension, Primary Aldosteronism, Hypokalemia
- Trial name
- SSTT (NCT06569589)
- Testing
- 23NaMRI Scan, Potassium Chloride (KCl)
- Where
- 4 sites in Singapore
- Volunteers
- 80 people
- Sponsor
- Jens Titze
Diabetic Ketoacidosis
Comparison of a Low Dose to a Standard Dose of Insulin in Adult DKA in ICU to Reduce Metabolic Complications
Diabetic ketoacidosis (DKA), a frequent complication of diabetes, is the consequence of a profound insulin deficiency responsible for osmotic polyuria and thus major losses of water, glucose, sodium and potassium as well as a…
- Trial name
- LOSTINDIAB (NCT05443802)
- Testing
- Insulin 0.05 IU/kg/h, Insulin 0.10 IU/kg/h
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventricular Arrhythmias and Cardiac Arrest, Implantable Defibrillator User
Targeted Potassium Levels for Prevention of ICD Therapy
This study evaluates whether a rigorously controlled high-normal level of serum-potassium (4.5-5.0 mEq/L) using dietary recommendations, potassium supplements and mineralocorticoid receptor antagonists will results in a lower…
- Conditions
- Ventricular Arrhythmias and Cardiac Arrest, Implantable Defibrillator User, Hypokalemia, Hyperkalemia
- Trial name
- NCT03833089
- Testing
- Targeted serum potassium level
- Where
- 3 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Kidney Disease on Hemodialysis, Hypokalemia
the Cardioprotective Effects of Improving Potassium Variability in Maintenance Hemodialysis Patients
The management of serum potassium in maintenance hemodialysis（MHD ）patients is one of the hot topics at present. In order to control hyperkalemia in dialysis patients, the use of hypokalemic dialysate is the most important…
- Conditions
- Chronic Kidney Disease on Hemodialysis, Hypokalemia, Hyperkalemia, Myocardial Injury
- Trial name
- NCT06736184
- Testing
- Sodium Zirconium Cyclosilicate (SZC)
- Volunteers
- 100 people
- Sponsor
- Qianfoshan Hospital
Hyperkalemia, Hypokalemia
Artificial Intelligence Identified Dyskalemia Using Electrocardiogram (AIDE)
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of potassium abnormalities.
- Trial name
- NCT05118022
- Testing
- Artificial Intelligence identified Dyskalemia using Electrocardiogram (AIDE) system
- Where
- Taiwan
- Volunteers
- 14,989 people
- Sponsor
- National Defense Medical Center, Taiwan
Hypertension
Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate
Chlorthalidone (CTD) may produce various metabolic disturbances, including hypokalemia, activation of Renin-Angiotensin- Aldosterone (RAA) system, oxidative stress, dyslipidemia, Fibroblast growth factor 23 (FGF23) synthesis, and…
- Trial name
- NCT02665117
- Testing
- Potassium Magnesium Citrate (KMgCit), Potassium Chloride (KCl), Chlorthalidone
- Where
- 3 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Aldosterone-Producing Adenoma
CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis
The goal of this clinical trial is to evaluate the effectiveness of CXCR4 targeted PET imaging in preoperative localization diagnosis of primary aldosteronism (PA).
- Trial name
- NCT05839483
- Testing
- CXCR4
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Hypertension, Potassium Imbalance
Occurrence of Dyskalemia With Treatment for Hypertension
Hypertension is a major public health issue associated with significant morbidities and mortality. Fixed-dose combination (FDC) pills, combining 2 or more classes of antihypertensive medications have considerable appeal because…
- Trial name
- OK (NCT05155436)
- Testing
- Fixed Dose Combination pill of Telmisartan 40mg and Amlodipine 5 mg
- Where
- Bangladesh
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- National Heart Foundation of Bangladesh
Hyperkalemia, Hypokalemia
Description of the Clinical Outcomes of Hospitalized Patients With Heart Failure With Different Serum Potassium Levels
China National Heart Failure Registration Study (CN-HF) is a nationwide, hospital-based, multicentre, prospective registry study sponsored by Ministry of Science and Technology of the People's Republic of China.
- Conditions
- Hyperkalemia, Hypokalemia, Heart Failure
- Trial name
- SPLENDID (NCT05184998)
- Where
- China
- Volunteers
- 6,950 people
- Sponsor
- AstraZeneca
Renal Tubular Disorders in Children
Renal Tubular Disorders in Egyptian Children
Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders.
- Trial name
- NCT04845815
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Sohag University
Arterial Hypertension, Diabetes
Cicletanine in Hypertension With Diabetes: Added Magnesium Preserves Potassium and Sodium
Cicletanine, which has been approved and launched for hypertension in France and Germany, has promise beyond hypertension in critically-unmet needs such as diabetes.
- Conditions
- Arterial Hypertension, Diabetes, Hypokalemia, Hyponatremia
- Trial name
- CHAMP (NCT02709031)
- Testing
- Cicletanine + magnesium, Cicletanine
- Volunteers
- 24 people
- Sponsor
- Navitas Pharma
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Outcome of Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Adrenalectomy; Status
- Trial name
- PA_Outcome (NCT04428827)
- Testing
- Unilateral adrenalectomy in patients with unilateral disease
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- Changi General Hospital
Hypokalemia
The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis
The purpose of this study is to examine the impact of 4% sodium bicarbonate additive during peripheral intravenous potassium chloride replacement therapy for adult patients in a Medical/Surgical unit.
- Trial name
- Neut-WKBH (NCT02082717)
- Testing
- potassium chloride replacement, Experimental - 4% Sodium Bicarbonate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baptist Health South Florida
Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia
Hypomagnesemia Associated With Proton-Pump Inhibitor Use
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of…
- Conditions
- Proton Pump Inhibitor Adverse Reaction, Hypomagnesemia, Arrhythmias, Cardiac, Seizures
- Trial name
- PPI_HypoMg (NCT04426994)
- Testing
- proton pump inhibitor use
- Where
- Singapore
- Volunteers
- 211,672 people
- Sponsor
- Changi General Hospital